[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100270750":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":42,"responsibleParty":70,"collaborators":72,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":24,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":24,"overallStatus":59,"whyStopped":24,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Istituto Auxologico Italiano","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1","ACTIVE_COMPARATOR","Management strategy of blood pressure based on office BP as a guide to treatment",[13],"Other: Optimization of antihypertensive treatment based on office BP",{"label":15,"type":16,"description":17,"interventionNames":18},"Group 2","EXPERIMENTAL","Management strategy of blood pressure based on 24-hour ABPM as a guide to treatment",[19],"Other: Optimization of antihypertensive treatment based on 24-hour ABPM",[21,25],{"type":6,"name":22,"description":22,"armGroupLabels":23,"otherNames":24},"Optimization of antihypertensive treatment based on office BP",[9],null,{"type":6,"name":26,"description":26,"armGroupLabels":27,"otherNames":24},"Optimization of antihypertensive treatment based on 24-hour ABPM",[15],[29],{"name":30,"affiliation":5,"role":31},"Gianfranco Parati, MD","PRINCIPAL_INVESTIGATOR",[33,38],{"name":30,"role":34,"phone":35,"phoneExt":36,"email":37},"CONTACT","+390261911","2890","gianfranco.parati@unimib.it",{"name":39,"role":34,"phone":35,"phoneExt":40,"email":41},"Alberto Zanchetti, MD","2901","alberto.zanchetti@auxologico.it",[43,57],{"facility":5,"status":44,"city":45,"state":24,"zip":24,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"NOT_YET_RECRUITING","Milan","Italy","IT",{"type":49,"coordinates":50},"Point",[51,52],9.18951,45.46427,{"lat":52,"lon":51},[55],{"name":30,"role":34,"phone":56,"phoneExt":36,"email":37},"390261911",{"facility":58,"status":59,"city":60,"state":24,"zip":24,"country":61,"countryCode":24,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Fundacion Venezolana de Hipertension Arterial\u002FInstituto de Enfermedades Cardiovasculares de LUZ","RECRUITING","Maracaibo","Venezuela",{"type":49,"coordinates":63},[64,65],-71.61089,10.64232,{"lat":65,"lon":64},[68],{"name":69,"role":34,"phone":24,"phoneExt":24,"email":24},"Egle Silva, MD",{"type":71,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[73],{"name":74,"class":6},"European Society of Hypertension","100270750","masked-uncontrolled-hypertension-management-based-on-office-bp-or-on-out-of-office-ambulatory-bp-measurement-100270750",false,"NCT02804074","MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement","MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement (MASTER Study)","MASTER","Inclusion Criteria:\n\n* Male and female subjects\n* Age 35-80 years\n* Masked uncontrolled (in treatment) hypertension: office BP \\\u003C140\u002F90 mmHg, and one or more of the following situations:\n\n  * Ambulatory daytime BP \\>135\u002F85 mmHg\n  * Ambulatory night-time ABP \\> 120\u002F70 mmHg\n  * Ambulatory 24h ABP \\>130\u002F80 mmHg\n* eGFR ≥45 mL\u002Fmin\u002F1.73 m2 (CKD-EPI creatinine equation 2009)\n\nExclusion Criteria:\n\n* eGFR \\\u003C45 mL\u002Fmin\u002F1.73 m2 (CKD-EPI creatinine equation 2009), and in particular severe chronic renal failure defined as serum creatinine \\> 250 umol\u002Fl;\n* Patients in unstable clinical conditions;\n* Known secondary hypertension;\n* Orthostatic hypotension (SBP fall \\> 20 mmHg on standing);\n* Dementia (clinical diagnosis);\n* Hepatic disease as determined by either AST or ALT values \\> 2 times the upper limit of normal\n* History of gastrointestinal surgery or disorders which could interfere with drug absorption\n* Known allergy or contraindications to one of the drugs to be administered in the study\n* History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years\n* History of clinically significant autoimmune disorders such as systemic lupus erythematosus.\n* History of drug or alcohol abuse within the last 5 years\n* History of non-compliance to medical regimens and\u002For patients who are considered potentially unreliable\n* Inability or unwillingness to give free informed consent\n* Pregnancy or planned pregnancy during study period.","ALL","35 Years","80 Years",{"count":87,"type":88},1240,"ESTIMATED","INTERVENTIONAL",[91],"NA","MASTER study is a 4-year prospective, randomized, open-label, blinded-endpoint study (PROBE) comparing 2 management strategies 1) office BP as a guide to treatment, or 2) 24-hour ABP as a guide to treatment. Study objectives are to investigate whether a management strategy based on out-of-office BP (Ambulatory BP monitoring) versus a management strategy based on office BP measurements is associated with differences in outcome, including cardiovascular and renal intermediate end points at one year; cardiovascular events at 4 years and changes in a number of blood pressure-related variables throughout the study. Patients will be followed-up during the first year focusing on changes in left ventricular mass index (LVMI, co-primary endpoint) and Urinary albumin excretion (UAE, albumin\u002Fcreatinine ratio, co-primary end-point), and during the whole 48 month period for both changes in LVMI and UAE and events including all-cause mortality, CV morbidity and mortality, cerebral morbidity and mortality.A total of 1240 subjects will be recruited by 30 centers, taking into account a dropout rate of 15% (620 subjects per randomization arm).",[94],"Masked Hypertension","2026-03-25",{"date":97,"type":98},"2026-03-30","ACTUAL",{"date":100,"type":98},"2018-10-01",{"date":102,"type":88},"2026-12",{"name":5,"class":6},2]