[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100307028":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":27,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":10,"maxAge":10,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Duke University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Maternal Autoimmune Disease ReseArch (MADRA) Registry",null,"Women with autoimmune diseases who are pregnant",[13],{"name":14,"affiliation":15,"role":16},"Megan EB Clowse, MD, MPH","Duke Health","PRINCIPAL_INVESTIGATOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Laura Neil","CONTACT","919 684 8936","laura.k.neil@duke.edu",{"name":24,"role":20,"phone":25,"phoneExt":10,"email":26},"Edna Scarlett","919-684-6150","edna.scarlett@duke.edu",[28],{"facility":5,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Durham","North Carolina","27705","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-78.89862,35.99403,{"lat":39,"lon":38},[42,46],{"name":43,"role":20,"phone":44,"phoneExt":10,"email":45},"Megan Clowse, MD","919 681 2045","megan.clowse@duke.edu",{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100307028","maternal-autoimmune-disease-research-alliance-madra-registry-100307028",false,"NCT03276923","Maternal Autoimmune Disease Research Alliance (MADRA) Registry","MADRA","Inclusion Criteria:\n\n* Desire for pregnancy within 6 months or currently pregnant\n* Women with systemic autoimmune disease, including:\n* Lupus (systemic lupus erythematosus or cutaneous lupus)\n* Antiphospholipid Syndrome or positive antiphospholipid antibodies\n* Rheumatoid Arthritis\n* Scleroderma (systemic sclerosis)\n* Sjogren's Syndrome\n* Inflammatory Arthritis (including Psoriatic Arthritis and Ankylosing Spondylitis)\n* Undifferentiated Connective Tissue Disease (UCTD)\n* Vasculitis\n* Myositis (Polymyositis or Dermatomyositis)\n* Positive Ro\u002FSSA or La\u002FSSB antibodies\n\nExclusion Criteria:\n\n* Unable to speak English\n* Unable to provide informed consent\n* Unable to travel to Duke University for follow-up visits",true,"FEMALE",{"count":59,"type":60},1000,"ESTIMATED","100 Years","OBSERVATIONAL","This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases.\n\nThe main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy.\n\nPrior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outcomes. The future research will seek to better define these risk factors and to identify ways to may improve them.",[65,66,67,68,69,70,71],"Autoimmune Diseases","Pregnancy Related","Systemic Lupus Erythematosus","Cutaneous Lupus","Rheumatoid Arthritis","Sjogren's Syndrome","Scleroderma","2026-01-06",{"date":74,"type":75},"2026-01-08","ACTUAL",{"date":77,"type":75},"2018-01-01",{"date":79,"type":60},"2027-01-01",{"name":5,"class":6},1]