[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642748":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":23,"responsibleParty":42,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":25,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Clinical Nutrition Research Center, Illinois Institute of Technology","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Adults With Insulin-Dependent Type 2 Diabetes Mellitus",null,"Adults 18 to 65 years of age with insulin-dependent type 2 diabetes mellitus who will undergo a liquid meal tolerance test with frequent blood sampling over 4 hours following consumption of a standardized liquid meal. Participants will also undergo outpatient continuous glucose monitoring and wearable physical activity tracking during free-living conditions to support mathematical modeling of metabolic and physiologic responses.",[13],{"name":14,"affiliation":15,"role":16},"Indika Edirisinghe, Ph.D","Illinois Institute of Technology","PRINCIPAL_INVESTIGATOR",[18],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Chelsea Preiss, Clinical Research Manager, MS","CONTACT","312-567-5300","cpreiss@illinoistech.edu",[24],{"facility":15,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"RECRUITING","Chicago","Illinois","60616","United States","US",{"type":32,"coordinates":33},"Point",[34,35],-87.65005,41.85003,{"lat":35,"lon":34},[38,40],{"name":39,"role":20,"phone":21,"phoneExt":10,"email":22},"Chelsea Preiss, MS",{"name":41,"role":16,"phone":10,"phoneExt":10,"email":10},"Indika Edirisinghe, PhD",{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100642748","mathematical-modeling-of-blood-sugar-and-hormone-responses-in-insulin-dependent-type-2-diabetes-100642748",false,"NCT07650682","Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes","Mathematical Modeling of Type 2 Diabetes Mellitus","MT2D","Inclusion Criteria:\n\n* Men or women, 18-65 years of age\n* Diagnosed with insulin-dependent type 2 diabetes mellitus HbA1c ≥ 6.5% at screening\n* Current insulin therapy for ≥ 6 months prior to screening\n* Nonsmokers (past smokers can be allowed if they have abstained for a minimum of 12 months)\n* Judged to be in good health based on medical history (i.e., no clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease)\n* Able to provide informed consent\n* Able to comply with and perform the procedures requested by the protocol (including dietary restrictions, consumption of study foods, records of food diary, sample collection procedures, and study visit schedule)\n\nExclusion Criteria:\n\n* Men and women with known or suspected intolerance, allergies, or hypersensitivity to study foods\n* Men and women with low hemoglobin (Hgb) levels below 9.5 g\u002FdL at the screening visit, indicating anemia\n* Men and women with blood pressure \\>160 mmHg (systolic) \u002F 100 mmHg (diastolic) at the screening visit\n* Women who are pregnant or planning to become pregnant during the study\n* Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI.\n* Vegan or other extreme dietary regimens (e.g., Atkins diet, etc.) as judged by the investigator\n* History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional\n* Donated blood within the last 3 months\n* Unstable weight: gained or lost weight +\u002F- 5 kg (11 lbs) in previous 2 months\n* Unusual working hours i.e., working overnight (e.g. 3rd shift)","ALL","18 Years","65 Years",{"count":56,"type":57},25,"ESTIMATED","OBSERVATIONAL","This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized liquid mixed meal to measure glucose, insulin, glucagon, C-peptide, and triglyceride responses. Participants will also use continuous glucose monitoring and wearable physical activity tracking devices during free-living conditions.\n\nThe purpose of this study is to develop mathematical models and digital representations (\"digital twins\") of people with type 2 diabetes mellitus. These models may help researchers better understand metabolic responses to meals, physical activity, and diabetes treatments, and may support future development of personalized diabetes technologies and therapies.",[61,62],"Type 2 Diabetes","Insulin Dependent Diabetes",[64,65,66],"Liquid Meal Test","Digital Twin","Continuous Glucose Monitoring","2026-06-12",{"date":69,"type":70},"2026-06-16","ACTUAL",{"date":72,"type":70},"2026-05-20",{"date":74,"type":57},"2027-03-20",{"name":5,"class":6},1]