[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617182":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":27,"centralContacts":42,"locations":48,"responsibleParty":82,"collaborators":27,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":27,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":111,"overallStatus":51,"whyStopped":27,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"ETH Zurich","OTHER",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"Healthy children","ACTIVE_COMPARATOR",[12],"Other: Iron absorption from RUTF on Day 0",{"label":14,"type":15,"description":16,"interventionNames":17},"Children with MAM\u002FSAM","EXPERIMENTAL","children with moderate or severe acute malnutrition",[12,18,19,20,21],"Dietary Supplement: Treatment with RUTF for 80 days","Other: Iron absorption from RUTF on Day 20","Other: Iron absorption from RUTF on Day 40","Other: Iron absorption from RUTF on Day 60",[23,28,33,36,39],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"Iron absorption from RUTF on Day 0","RUFT with 57Fe",[14,9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"DIETARY_SUPPLEMENT","Treatment with RUTF for 80 days","Daily RUTF intake",[14],{"type":6,"name":34,"description":25,"armGroupLabels":35,"otherNames":27},"Iron absorption from RUTF on Day 20",[14],{"type":6,"name":37,"description":25,"armGroupLabels":38,"otherNames":27},"Iron absorption from RUTF on Day 40",[14],{"type":6,"name":40,"description":25,"armGroupLabels":41,"otherNames":27},"Iron absorption from RUTF on Day 60",[14],[43],{"name":44,"role":45,"phone":46,"phoneExt":27,"email":47},"Suzane Nyilima, MSc","CONTACT","+254702836210","suzane.nyilima@gmail.com",[49,65],{"facility":50,"status":51,"city":52,"state":53,"zip":27,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"ETH\u002FOxford\u002FJKUAT research facility","RECRUITING","Msambweni","Kwale County","Kenya","KE",{"type":57,"coordinates":58},"Point",[59,60],39.48265,-4.4619,{"lat":60,"lon":59},[63],{"name":64,"role":45,"phone":46,"phoneExt":27,"email":47},"Suzane Nyilima",{"facility":66,"status":67,"city":68,"state":27,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"ETH Zurich, Laboratory of Clinical Biopharmacy, Zurich, 8092","NOT_YET_RECRUITING","Zurich","8006","Switzerland","CH",{"type":57,"coordinates":73},[74,75],8.55,47.36667,{"lat":75,"lon":74},[78],{"name":79,"role":45,"phone":80,"phoneExt":27,"email":81},"Prof. Dr. Stoffel","+41 44 632 83 93","nicole.stoffel@pharma.ethz.ch",{"type":83,"investigatorFullName":84,"investigatorTitle":85,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Nicole Stoffel","Assistantprofessor","100617182","maximizing-the-benefits-of-iron-in-ready-to-use-therapeutic-foods-for-malnourished-children-in-kenya-100617182",false,"NCT07315295","Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya","Maximizing the Benefits of Iron in Ready-to-use Therapeutic Foods for Malnourished Children in Kenya","SAMI","Inclusion Criteria:\n\nmalnourished children:\n\n* severe acute malnutrition (SAM): WHZ \\\u003C -3.0\n* moderate acute malnutrition (MAM): WHZ \\\u003C -2.0 a\n* treated as outpatients (no acute medical conditions and a positive appetite test)\n\nhealthy children:\n\n\\- healthy: HAZ, WAZ and WHZ = 0\n\nExclusion Criteria (both groups):\n\n* Hemoglobin ≤7 g\u002FdL\n* Presence of acute medical conditions requiring inpatient management",true,"ALL","12 Months","54 Months",{"count":99,"type":100},68,"ESTIMATED","INTERVENTIONAL",[103],"NA","Reports from the Kenya Red Cross Society (KRCS) in Kwale County, southern Kenya, indicate a limited impact of Ready-to-Use Therapeutic Foods (RUTFs) on malnutrition or anemia. The current RUTF formulation may have an excessively high iron content. In severely acutely malnourished (SAM) children, iron cannot be properly absorbed, leading to life-threatening diarrhea. The overall aim of this project is to develop an improved RUTF treatment that addresses acute malnutrition and anemia in children, ensuring both safety and efficacy. Specifically, to assess the impact of malnutrition on fractional iron absorption (FIA) from RUTFs in children, by comparing healthy children to those with acute malnutrition and by tracking changes in FIA in malnourished children over the course of treatment.",[106,107,108,109,110],"Iron Absorption","Iron Deficiencies","Severly Acutely Malnourished Children","Malnutrition in Children","Anemia",[112,113,114,115],"Ready to use therapeutic foods (RUFTs)","Severe acute malnutrition (SAM)","Stable isotopes","Iron bioavailability","2025-12-18",{"date":118,"type":119},"2026-01-02","ACTUAL",{"date":121,"type":100},"2025-12-23",{"date":123,"type":100},"2026-06-30",{"name":5,"class":6},2]