[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100289553":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":88,"collaborators":91,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":10,"eligibilityCriteria":100,"healthyVolunteers":101,"sex":102,"minAge":10,"maxAge":10,"enrollmentInfo":103,"targetDuration":10,"studyType":106,"phases":10,"briefSummary":107,"conditions":108,"keywords":10,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Proband",null,"Proband - the person who is the first to present with a diagnosis of AVC",{"label":13,"type":10,"description":14,"interventionNames":10},"Family members (consultands)","First-degree relatives of probands with AVC (who may be living or deceased) In some circumstances where multiple family members are or may be affected, they may be eligible.",[16],{"name":17,"affiliation":5,"role":18},"Virend Somers, PhD, MD","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Nicholas Wozniak","CONTACT","+1 507 2558794","wozniak.nicholas@mayo.edu",{"name":26,"role":22,"phone":10,"phoneExt":10,"email":27},"Anwar A Chahal, Ph.D.","chahal.anwar@mayo.edu",[29,56],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-92.4699,44.02163,{"lat":40,"lon":39},[43,45,49,52,54],{"name":21,"role":22,"phone":44,"phoneExt":10,"email":24},"507-255-8794",{"name":46,"role":22,"phone":47,"phoneExt":10,"email":48},"Shahid Karim, MD","507-422-0766","karim.shahid@mayo.edu",{"name":50,"role":51,"phone":10,"phoneExt":10,"email":10},"Anwar A Chahal, MB ChB MRCP","SUB_INVESTIGATOR",{"name":53,"role":18,"phone":10,"phoneExt":10,"email":10},"Virend K Somers, MD PhD",{"name":55,"role":18,"phone":10,"phoneExt":10,"email":10},"Grace Lin, MD",{"facility":57,"status":30,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Royal Papworth Hospital NHS Foundation Trust","Papworth Everard","Cambridge","CB23 3RE","United Kingdom","UK",{"type":37,"coordinates":64},[65,66],-0.11827,52.24893,{"lat":66,"lon":65},[69,72,74,76,78,80,82,84,86],{"name":70,"role":22,"phone":10,"phoneExt":10,"email":71},"Greg Mellor, MD","CVGenetics@nhs.net",{"name":73,"role":22,"phone":10,"phoneExt":10,"email":71},"Anwar A Chahal, MBChB PhD",{"name":75,"role":18,"phone":10,"phoneExt":10,"email":10},"Andrew A Grace, PhD FRCP FHRS",{"name":77,"role":51,"phone":10,"phoneExt":10,"email":10},"Anwar A Chahal, MBChB MRCP",{"name":79,"role":51,"phone":10,"phoneExt":10,"email":10},"Greg Mellor, MD MRCP",{"name":81,"role":51,"phone":10,"phoneExt":10,"email":10},"Lynne Williams, MBChB MRCP PhD",{"name":83,"role":51,"phone":10,"phoneExt":10,"email":10},"Sharad Agarwal, MD FRCP",{"name":85,"role":51,"phone":10,"phoneExt":10,"email":10},"Bobby Agrawal, BMBS FRCS FRCR",{"name":87,"role":51,"phone":10,"phoneExt":10,"email":10},"Doris M Rassl, MBBS MRCPath",{"type":18,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Virend Somers, MD, PhD","Principal Investigator",[92],{"name":93,"class":6},"Cambridge University Hospitals NHS Foundation Trust","100289553","mayo-avc-registry-and-biobank-100289553",false,"NCT03049254","Mayo AVC Registry and Biobank","Identification of Novel Genetic Variants and Biomarkers of Disease Progression in Arrhythmogenic Cardiomyopathy","Inclusion Criteria:\n\n* Patients with a diagnosis of a non-MI SCA who survived\n* Patients with a non-MI SCD\n* Patient with a SCA associated with seizures, epilepsy, syncope, drowning and near-drowning, where a cardiomyopathy is suspected\n* Family member of a patient diagnosed with primary cardiomyopathy (including HCM, idiopathic DCM, AVC)\n\nExclusion Criteria:\n\n* Patients with a clear, unambiguous known cause of SCA or SCD such as myocardial infarction or heart failure secondary to ischemic heart disease\n* Significant coronary artery disease (Epicardial coronary artery stenosis \\>50%) which can explain degree of LV dysfunction\n* Those unwilling to provide written consent or assent",true,"ALL",{"count":104,"type":105},1000,"ESTIMATED","OBSERVATIONAL","Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as the disease process can be subtle, but sufficient enough, so that the first event is sudden death.\n\nThe Mayo Clinic AVC Registry is a collaboration between Mayo Clinic, Rochester, USA and Papworth Hospital, Cambridge University Hospitals, Cambridge, UK. The investigators aim to enroll patients with a history of AVC or sudden cardiac death which may be due to AVC, from the US and UK. Family members who are blood-relatives will also be invited, including those who do not have the condition. Data collected include symptoms, ECG, echocardiographic, MRI, Holter, loop recorder, biopsies, exercise stress testing, blood, buccal and saliva samples.\n\nObjectives of the study:\n\n1. Discover new genes or altered genes (variants) which cause AVC\n2. Identify biomarkers which predict (2a) disease onset, (2b) disease progression, (2c) and the likelihood of arrhythmia (ventricular, supra-ventricular and atrial fibrillation)\n3. Correlate genotype with phenotype in confirmed cases of AVC followed longitudinally using clinical, electrocardiographic and imaging data.\n4. Characterize desmosomal changes in buccal mucosal cells with genotype and validate with gold-standard endomyocardial biopsies",[109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125],"Arrhythmogenic Right Ventricular Cardiomyopathy","Cardiomyopathies","Heart Diseases","Cardiovascular Diseases","Sudden Cardiac Arrest","Sudden Cardiac Death","Arrhythmogenic Right Ventricular Dysplasia","Arrhythmogenic Ventricular Cardiomyopathy","Familial Dilated Cardiomyopathy","Cardiovascular Abnormalities","Sarcoidosis","Cardiac Arrhythmia","Cardiac Sarcoidosis","Myocarditis","Inflammatory Cardiomyopathy","Ventricular Tachycardia","Right Ventricular Outflow Tract Ventricular Tachycardia","2026-04-22",{"date":128,"type":129},"2026-04-27","ACTUAL",{"date":131,"type":129},"2018-02-09",{"date":133,"type":105},"2027-03",{"name":5,"class":6},2]