[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577009":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":46,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":71,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Centre Francois Baclesse","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Case group",null,"participant with a hereditary predisposition linked to a BRCA1\u002F2 mutation (case)",[13],"Genetic: Mutation Burden cfMB analysis",{"label":15,"type":10,"description":16,"interventionNames":17},"Control group","participant not carrying a hereditary predisposition linked to a BRCA1\u002F2 mutation (control) participant from the same sibling as the carrier participant (sister)",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"GENETIC","Mutation Burden cfMB analysis","Blood samples will be collected (one time only)",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Louise May THIBAUT, Medical Doctor","CONTACT","0231455050","lm.thibaut@baclesse.unicancer.fr",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":10,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Centre François Baclesse","RECRUITING","Caen","France","FR",{"type":38,"coordinates":39},"Point",[40,41],-0.35912,49.18585,{"lat":41,"lon":40},[44],{"name":45,"role":27,"phone":10,"phoneExt":10,"email":29},"Louise May THIBAUT, MD",{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100577009","measurement-of-circulating-mutation-burden-100577009",false,"NCT06792721","MEASUREMENT OF CIRCULATING MUTATION BURDEN","EVALUATION OF CANCER RISK BY MEASUREMENT OF CIRCULATING MUTATIONAL BURDEN IN CARRIERS OF A GENETIC PREDISPOSITION","cRISK","Inclusion Criteria:\n\n* Female participant\n* Participant undergoing oncogenetic follow-up at the Centre François Baclesse\n* Participant belonging to a pair of related biological siblings\n* Within the sibling pair, one participant is a carrier of a hereditary predisposition linked to a BRCA1\u002F2 mutation (case), and the other participant is not a carrier (control).\n* Participant between 30 and 50 years of age\n* Participant affiliated to a social security scheme\n* Participant having given her consent to participate by signing an informed consent form prior to any specific study-related procedure.\n\nExclusion Criteria:\n\n\\-",true,"FEMALE","30 Years","50 Years",{"count":61,"type":62},30,"ESTIMATED","OBSERVATIONAL","Cancer-free women with a hereditary predisposition to breast and\u002For ovarian cancer",[66,67,68,69,70],"Breast Carcinoma","Genetic Predisposition to Cancer","BRCA Mutation","cfMB","Mutation Burden",[69,72,73,74,75],"predisposition to cancer","BRCA1","BRCA2","breast cancer","2025-07-07",{"date":78,"type":79},"2025-07-08","ACTUAL",{"date":81,"type":79},"2025-07-04",{"date":83,"type":62},"2027-12-30",{"name":5,"class":6},1]