[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553486":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":25,"responsibleParty":40,"collaborators":25,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":25,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":25,"enrollmentInfo":52,"targetDuration":25,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":25,"overallStatus":61,"whyStopped":25,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":25},{"fullName":5,"class":6},"Loyola University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Kinematic Total Knee Arthroplasty","EXPERIMENTAL","KA-TKAs recreate the native joint line, hip-knee-ankle angle, and rotation of the pre-arthritic joint.",[13],"Procedure: Total knee arthroplasty",{"label":15,"type":16,"description":17,"interventionNames":18},"Mechanical Total Knee Arthroplasty","ACTIVE_COMPARATOR","MA-TKAs are performed by which the distal femur and proximal tibia cuts are made perpendicular to the mechanical axis, a line connecting the center of the femoral head to the center of the ankle. These cuts are classically described as a 6-degree valgus cut of the distal femur and a 0-degree cut of the proximal tibia in relation to the mechanical axis. MA-TKAs create a 0-degree hip-knee-ankle angle.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Total knee arthroplasty","All patients indicated for primary total knee arthroplasty will receive a cruciate-retaining cemented or cementless implant system, utilizing either MA or KA methodology.",[9,15],null,[27],{"name":28,"affiliation":29,"role":30},"Nicholas Brown, MD","Loyola University Chicago","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},"Hanna House, MD","CONTACT","2602414659","hanna.e.house@luhs.org",{"name":28,"role":34,"phone":38,"phoneExt":25,"email":39},"3194004327","nicholas.brown002@lumc.edu",{"type":41,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100553486","mechanical-alignment-versus-kinematic-alignment-total-knee-arthroplasty-100553486",false,"NCT06486714","Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty","Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty: A Randomized Control Trial","Inclusion Criteria:\n\n* Patients 18 years or older presenting to our institutions indicated for a primary total knee arthroplasty\n\nExclusion Criteria:\n\n* Revision TKA\n* Patients with prior injuries to study knee\n* Patients with history of childhood knee disease\n* Patients who cannot complete questionnaires in English\n* Patients with comorbidities preventing surgery\n* Patients who are not able to provide informed consent",true,"ALL","18 Years",{"count":53,"type":54},96,"ESTIMATED","INTERVENTIONAL",[57],"NA","Historically, total knee arthroplasty (TKA) has been performed with the goal of restoring a neutral mechanical axis, eliminating the average 3 degrees of valgus and varus of the distal femur and proximal tibia joint lines respectively. This is thought to provide a more stable and neutral joint-bearing surface. Because of this shift to a 0-degree knee angle, soft tissue releases are frequently required to balance the knee after making the distal tibia and proximal tibia cuts. More recently and increasingly, TKAs have been performed with a goal of restoring kinematic, or anatomic, alignment of the knee. This is thought to provide a more normal native knee angle, with the hopes of precluding the necessity of soft tissue releases to balance the knee. While some studies are promising regarding kinematically aligned TKAs (KA-TKA), at present, it is unclear how these compare to mechanically aligned TKAs (MA-TKA) in terms of patient reported outcome measures (PROM) when compared head-to-head.\n\nThis study will randomize patients to receive either cemented MA-TKA or KA-TKA with the goal of assessing pain scores and PROMs at various time points following surgery.",[60],"Knee Osteoarthritis","NOT_YET_RECRUITING","2025-12-02",{"date":64,"type":65},"2025-12-09","ACTUAL",{"date":67,"type":54},"2026-03-01",{"date":69,"type":54},"2027-06-30",{"name":5,"class":6}]