[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554041":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":27,"locations":37,"responsibleParty":48,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":71,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Assiut University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Paients with Successful weaning from Mechanical Ventilation",null,"The criteria for successful extubation: successful extubation was defined as the ability to maintain spontaneous breathing for at least 48 h, without any ventilatory support.",[13,14],"Other: Chest ultrasound","Other: Calculation of Mechanical Power on the first day of intubation and before First trial of weaning:",{"label":16,"type":10,"description":17,"interventionNames":10},"Patients with failed weaning from Mechanical Ventilation","failure extubation was defined as the reconnection to ventilator (invasive or noninvasive) within 48 h due to respiratory failure or other reasons. Extubation and the reconnection to ventilator were all based on SBT results and physicians' decision (5,9).",[19,23],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Chest ultrasound","to assess diaphragmatic excursion (DE(. M-mode was used to record the movement of the diaphragm during tidal breathing when the sampling line and diaphragm were as vertical as possible (not \\\u003C 70°). The data was measured from the first respiratory cycle at 0 min after SBT.",[9],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"Calculation of Mechanical Power on the first day of intubation and before First trial of weaning:","Total respiratory rate (RR). Positive end-expiratory pressure (PEEP) (the external or applied PEEP) recorded, not the total PEEP, or intrinsic PEEP. The plateau pressure (Pplat) was measured during an inspiratory pause on the ventilator. Peak inspiratory pressure (Ppeak) should be obtained while the patient is relaxed, not coughing or moving in bed. MP was calculated according to Gattinoni's simplified mechanical power equation as follows (3,8):\n\nMP(J\u002Fmin)=0.098×VT×RR×(Ppeak-0.5×ΔP).",[9],[28,34],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Mohamed M Moustafa Awad, Assistant Lecturer","CONTACT","0l023420225","20","mohamedmamdouh15794@gmail.com",{"name":35,"role":30,"phone":36,"phoneExt":32,"email":10},"Hoda A Makhlouf, Professor","01001529442",[38],{"facility":5,"status":10,"city":39,"state":10,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":10},"Asyut","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],31.18368,27.18096,{"lat":46,"lon":45},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mohamed Mamdouh Moustafa","Assistant Lecturer","100554041","mechanical-power-as-a-predictor-for-weaning-in-chronic-obstructive-pulmonary-disease-patients-prospective-cohort-study-100554041",false,"NCT06493929","Mechanical Power As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients :Prospective Cohort Study.","Inclusion Criteria:\n\n* All COPD mechanically ventilated patients admitted to respiratory intensive care unit and eligible for weaning according to European respiratory society 2016 (5).\n\nExclusion Criteria:\n\n\\- 1. Patients with associated lung pathology that may alter lung mechanics (Bronchiectasis, interstitial lung diseases, lung scarring) will be excluded from the study.\n\n2\\. Tracheostomized patients.","ALL","18 Years","100 Years",{"count":62,"type":63},84,"ESTIMATED","OBSERVATIONAL","The primary objective is to evaluate the mechanical power as a predictor of weaning of mechanical ventilation in COPD patients hospitalized in the respiratory intensive care unit of Assiut University Hospital The secondary objective is to compare between mechanical power and diaphragmatic excursion (DE) assessed by ultrasound as a predictor of weaning in these patients. Also, to investigate the association between MP and DE and mortality in these patients",[67],"Mechanical Power",[69,70],"Mechanical power","Weaning","NOT_YET_RECRUITING","2024-11-29",{"date":74,"type":75},"2024-12-03","ACTUAL",{"date":77,"type":63},"2024-12-01",{"date":79,"type":63},"2026-08-01",{"name":5,"class":6},1]