[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644563":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":36,"collaborators":25,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":25,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":25,"enrollmentInfo":50,"targetDuration":25,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":25,"overallStatus":61,"whyStopped":25,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":25},{"fullName":5,"class":6},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"group A; VCV First, Then PRVC","EXPERIMENTAL","Following the stabilization of pneumoperitoneum, participants will be ventilated using the Volume-Controlled Ventilation (VCV) mode for 10 minutes. At the end of this period, respiratory data and mechanical power values will be recorded. Immediately after, the ventilator will be switched to the Pressure-Regulated Volume Control (PRVC) mode with equivalent settings. After another 10-minute stabilization period in PRVC mode, a second set of measurements will be recorded.",[13,14],"Device: Volume-Controlled Ventilation (VCV)","Device: Pressure-Regulated Volume Control (PRVC)",{"label":16,"type":10,"description":17,"interventionNames":18},"group B; PRVC First, Then VCV","Following the stabilization of pneumoperitoneum, participants will be ventilated using the Pressure-Regulated Volume Control (PRVC) mode for 10 minutes. At the end of this period, respiratory data and mechanical power values will be recorded. Immediately after, the ventilator will be switched to the Volume-Controlled Ventilation (VCV) mode with equivalent settings. After another 10-minute stabilization period in VCV mode, a second set of measurements will be recorded.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Volume-Controlled Ventilation (VCV)","Participants will be ventilated with the traditional Volume-Controlled Ventilation (VCV) mode. Tidal volume, respiratory rate, PEEP, and I:E ratio will be set according to the study protocol and kept constant during the measurement period.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Pressure-Regulated Volume Control (PRVC)","Participants will be ventilated with the Pressure-Regulated Volume Control (PRVC) mode. This is a hybrid mode that uses a decelerating flow to deliver the target tidal volume at the lowest possible pressure. Settings will be identical to the VCV mode for each patient.",[9,16],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"arif timuroglu, MD","CONTACT","+905072601980","ariftimuroglu@yahoo.com",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Arif Timuroğlu, MD","Principal Investigator","100644563","mechanical-power-during-different-ventilation-modes-in-laparoscopic-surgery-100644563",false,"NCT07670494","Mechanical Power During Different Ventilation Modes in Laparoscopic Surgery","Comparison of Mechanical Power in Pressure-Regulated Volume Control and Volume-Controlled Ventilation Modes During Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Patients undergoing elective laparoscopic cholecystectomy surgery.\n* Patients between 18 and 75 years of age.\n* American Society of Anesthesiologists (ASA) physical status I, II or III.\n* Body Mass Index (BMI) between 18.5 and 35 kg\u002Fm².\n* Voluntary written informed consent for participation.\n\nExclusion Criteria:\n\n* History of significant chronic obstructive pulmonary disease (COPD) or asthma.\n* Previous lung resection or major thoracic surgery.\n* Heavy smokers (more than 20 cigarettes per day).\n* Presence of spontaneous breathing effort during mechanical ventilation.\n* Conversion from laparoscopic surgery to open surgery during the procedure.\n* Emergency surgery cases.\n* Known pregnancy.",true,"ALL","18 Years",{"count":51,"type":52},80,"ESTIMATED","INTERVENTIONAL",[55],"NA","This study investigates how different breathing machine (ventilator) settings affect the energy delivered to the lungs during surgery. Mechanical power is a measure of this energy, and high levels can sometimes lead to lung irritation. In clinical practice, a mode called Pressure-Regulated Volume Control (PRVC) is often used because it lowers the \"peak\" pressure in the airways, which is generally thought to be safer. However, doctors have noticed that even though the peak pressure goes down in PRVC mode, the total mechanical power displayed on the monitor might actually increase compared to the standard Volume-Controlled Ventilation (VCV) mode. In this study, patients undergoing gallbladder surgery will be monitored using both ventilation modes in a random order. The researchers will compare the machine-calculated mechanical power for both modes to see if the perceived benefit of lower peak pressure in PRVC actually results in lower overall energy transfer to the lungs.",[58,59,60],"Laparoscopic Cholecystectomy","Mechanical Ventilation","Ventilator-Induced Lung Injury","NOT_YET_RECRUITING","2026-06-26",{"date":64,"type":65},"2026-06-30","ACTUAL",{"date":67,"type":52},"2026-07-01",{"date":69,"type":52},"2026-08-12",{"name":5,"class":6}]