[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555317":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":27,"locations":10,"responsibleParty":33,"collaborators":10,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":39,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":51,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Paients with Successful weaning",null,"The procedure of weaning from mechanical ventilation will be considered as early as possible. Patients who will be mechanically ventilated \\>24 h will be underwent daily screen of subjective and objective indices for assessment of readiness to wean. Weaning will be conducted according to European Respiratory Society guidelines (ERS) (5).\n\nThe criteria for successful extubation: successful extubation was defined as the ability to maintain spontaneous breathing for at least 48 h, without any ventilatory support.",[13,14],"Other: Calculation of Mechanical Power.","Other: Measurement Diaphragmatic Excursion after first SBT",{"label":16,"type":10,"description":17,"interventionNames":10},"Patients with failed weaning","the reconnection to ventilator (invasive or noninvasive) within 48 h due to respiratory failure or other reasons. Extubation and the reconnection to ventilator were all based on SBT results and physicians' decision (5,9).",[19,23],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Calculation of Mechanical Power.","Total respiratory rate (RR). Positive end-expiratory pressure (PEEP) (the external or applied PEEP) recorded, not the total PEEP, or intrinsic PEEP. The plateau pressure (Pplat) was measured during an inspiratory pause on the ventilator. Peak inspiratory pressure (Ppeak) should be obtained while the patient is relaxed, not coughing or moving in bed. MP was calculated according to Gattinoni's simplified mechanical power equation as follows (3,8):\n\nMP(J\u002Fmin)=0.098×VT×RR×(Ppeak-0.5×ΔP).",[9],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"Measurement Diaphragmatic Excursion after first SBT","Chest ultrasound to assess diaphragmatic excursion (DE(. M-mode was used to record the movement of the diaphragm during tidal breathing when the sampling line and diaphragm were as vertical as possible (not \\\u003C 70°). The data was measured from the first respiratory cycle at 0 min after SBT. The DE at 0 min, 5 min, and 30 min of SBT was respectively named as DE0, DE5, and DE30. The variation of right DE between each time point was named as ΔDE30-5 and ΔDE30-0. (7)",[9],[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Mohamed Mamdouh Awad, Master Degree of Chest Diseses","CONTACT","2001023420225","mohamedmamdouh15794@gmail.com",{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mohamed Mamdouh Moustafa","Assistant Lecturer","100555317","mechanical-power-versus-diaphragmatic-excursion-as-a-predictor-for-weaning-in-chronic-obstructive-pulmonary-disease-patients-100555317",false,"NCT06510517","Mechanical Power Versus Diaphragmatic Excursion As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients","Mechanical Power Versus Diaphragmatic Excursion As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients: Prospective Cohort Study","weaning","Inclusion Criteria:\n\nAll COPD patients who are mechanically ventilated patients. Must be eligible for weaning according to European respiratory society 2016.\n\nExclusion Criteria:\n\n1. Patients with Bronchiectasis, interstitial lung diseases, lung scarring.\n2. Tracheostomized patients.","ALL","18 Years","100 Years",{"count":49,"type":50},84,"ESTIMATED","8 Weeks","OBSERVATIONAL","The primary objective is to evaluate the mechanical power as a predictor of weaning of mechanical ventilation in COPD patients hospitalized in the respiratory intensive care unit of Assiut University Hospital.\n\nThe secondary objective is to compare between mechanical power and diaphragmatic excursion (DE) assessed by ultrasound as a predictor of weaning in these patients. Also, to investigate the association between MP and DE and mortality in these patients",[55],"Mechanical Power",[57,58],"Mechanical power","Weaning","NOT_YET_RECRUITING","2024-11-29",{"date":62,"type":63},"2024-12-03","ACTUAL",{"date":65,"type":50},"2024-12-01",{"date":67,"type":50},"2026-08-01",{"name":5,"class":6}]