[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552982":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":18,"locations":26,"responsibleParty":44,"collaborators":7,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":7,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":7,"enrollmentInfo":56,"targetDuration":7,"studyType":59,"phases":7,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":29,"whyStopped":7,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Beijing Sanbo Brain Hospital","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"PROCEDURE","Mechanical ventilation","After replacing the electrode, we'll monitor the EEG activity of the hippocampus and other cortex regions while weaning off mechanical ventilation.",[14],{"name":15,"affiliation":16,"role":17},"Zhonghua Shi, PhD,MD","Capital Medical University","PRINCIPAL_INVESTIGATOR",[19,23],{"name":15,"role":20,"phone":21,"phoneExt":7,"email":22},"CONTACT","010-62856764","z.shi@mail.ccmu.edu.cn",{"name":24,"role":20,"phone":21,"phoneExt":7,"email":25},"Xiang Qi","13643112610@163.com",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Beijing Sanbo Brain Hospital, Capital Medical University","RECRUITING","Beijing","Beijing Municipality","100090","China","CN",{"type":36,"coordinates":37},"Point",[38,39],116.39723,39.9075,{"lat":39,"lon":38},[42],{"name":43,"role":20,"phone":7,"phoneExt":7,"email":7},"Zhonghua Shi, PhD, MD",{"type":17,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Zhonghua Shi, MD, PhD","Deputy president of the department ICU","100552982","mechanical-ventilation-on-hippocampus-100552982",false,"NCT06480162","Mechanical Ventilation on Hippocampus","Impact of Mechanical Ventilation on Hippocampal Oscillation and Respiratory-hippocampus Coupling","Inclusion Criteria:\n\n* Age: ≥ 18 years\n* ASA: I - II\n* w\u002F electrode inside hippocampus (≥ 1 contacts)\n* Singed consent form\n\nExclusion Criteria:\n\n* Seizure occurrence ≤ 36 hours before op.\n* Structural brain damage\n* History of using: opioids, enzyme-inducing medications, sleep aids, or excessive alcohol consumption\n* History of mechanical ventilation (\\>24h)\n* Cognitive impairment\n* Operation within 6 months\n* Participate in other clinical trials in the last four weeks\n* Pregnant or breastfeeding","ALL","18 Years",{"count":57,"type":58},20,"ESTIMATED","OBSERVATIONAL","Ventilator-associated brain injury (VABI) frequently occurs in ICU patients. Although animal studies indicate the hippocampus as a key target of VABI, its relevance in human patients remains uncertain. In this study, the investigators aim to monitor hippocampal EEG activity during the weaning process of patients off mechanical ventilation, and also exploring the coupling between breathing patterns and hippocampal activity.",[62,63],"Mechanical Ventilation Complication","Brain Injuries",[65,66,67],"Ventilator Associated Brain Injury","Hippocampus Oscillation","Mechanical Ventilation","2024-08-06",{"date":70,"type":71},"2024-08-09","ACTUAL",{"date":73,"type":71},"2024-05-08",{"date":75,"type":58},"2025-06-01",{"name":5,"class":6},1]