[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584795":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":64,"collaborators":25,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":25,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"A","EXPERIMENTAL","Arm A will complete the Ketogenic Diet intervention first, followed by the Control Diet intervention after a 4-week washout period.",[13,14],"Behavioral: Ketogenic Diet","Behavioral: Control Diet",{"label":16,"type":10,"description":17,"interventionNames":18},"B","Arm B will complete the Control Diet intervention first, followed by the Ketogenic Diet intervention after a 4-week washout period.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Ketogenic Diet","Participants will consume an isocaloric ketogenic diet for 4 weeks with all food provided as packed-out meals.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Control Diet","Participants will consume an isocaloric control diet for 4 weeks with all food provided as packed-out meals.",[9,16],[31],{"name":32,"affiliation":5,"role":33},"Max C Petersen, M.D., Ph.D.","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Frannie Wilkinson, M.A.","CONTACT","(314) 362-0590","francesw@wustl.edu",{"name":32,"role":37,"phone":41,"phoneExt":25,"email":42},"314-362-8352","max.p@wustl.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","St Louis","Missouri","63110","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-90.19789,38.62727,{"lat":55,"lon":54},[58,61,63],{"name":59,"role":37,"phone":38,"phoneExt":25,"email":60},"Nikki Plassmeyer, M.A., R.D.N., L.D.","nikkip@wustl.edu",{"name":32,"role":37,"phone":62,"phoneExt":25,"email":42},"314-362-8450",{"name":32,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":65,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100584795","mechanism-of-ketogenic-diet-induced-hypercholesterolemia-100584795",false,"NCT06894004","Mechanism of Ketogenic Diet-Induced Hypercholesterolemia","Inclusion Criteria:\n\n1. age ≥ 18 and \\\u003C 40 years\n2. BMI ≥ 18.5 and \\\u003C 25.0 kg\u002Fm2\n3. baseline serum LDL-c \\\u003C 150 mg\u002FdL (\\\u003C 3.9 mmol\u002FL)\n4. baseline serum TG \\\u003C 100 mg\u002FdL (\\\u003C 1.1 mmol\u002FL)\n5. HbA1c ≤ 5.6%.\n\nExclusion Criteria:\n\n1. personal or family history of familial hypercholesterolemia\n2. current use of lipid-lowering drugs\n3. currently on a ketogenic diet and unwilling to change diet\n4. current tobacco use\n5. hypertension\n6. prediabetes or diabetes\n7. elevated Lp(a) \\> 6.5% of ApoB-containing lipoproteins at baseline\n8. oral contraceptive use\n9. contraindication to heparin\n10. known atherosclerotic cardiovascular disease\n11. unwilling to abstain from alcohol",true,"ALL","18 Years","39 Years",{"count":77,"type":78},100,"ESTIMATED","INTERVENTIONAL",[81],"NA","Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify \"responders\" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.",[84],"Hypercholesterolemia and Hyperlipidemia",[86,87,88,89],"LDL-cholesterol","cholesterol","ketogenic diet","lipoprotein kinetics","2026-03-19",{"date":92,"type":93},"2026-03-23","ACTUAL",{"date":95,"type":93},"2025-02-24",{"date":97,"type":78},"2030-11-30",{"name":5,"class":6},1]