[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544366":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":40,"centralContacts":45,"locations":50,"responsibleParty":66,"collaborators":10,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":10,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":10,"maxAge":10,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":10,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",[8,14,18,22,26,30],{"label":9,"type":10,"description":11,"interventionNames":12},"Under 40 years old",null,"Patients undergoing surgery with mechanical ventilation who are under 40 years old",[13],"Procedure: mechanical ventilation",{"label":15,"type":10,"description":16,"interventionNames":17},"40-50 years old","Patients undergoing surgery with mechanical ventilation who are 40-50 years old",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"50-60 years old","Patients undergoing surgery with mechanical ventilation who are 50-60 years old",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"60-70 years old","Patients undergoing surgery with mechanical ventilation who are 60-70 years old",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"70-80 years old","Patients undergoing surgery with mechanical ventilation who are 70-80 years old",[13],{"label":31,"type":10,"description":32,"interventionNames":33},"Over 80 years old","Patients undergoing surgery with mechanical ventilation who are over 80 years old",[13],[35],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"PROCEDURE","mechanical ventilation","Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.",[15,19,23,27,31,9],[41],{"name":42,"affiliation":43,"role":44},"Lai Jiang, PhD","Department of Anesthesia, Shanghai Xinhua hospital, Shanghai China","PRINCIPAL_INVESTIGATOR",[46],{"name":42,"role":47,"phone":48,"phoneExt":10,"email":49},"CONTACT","13817719616__","jianglaimz@sina.com",[51],{"facility":52,"status":53,"city":54,"state":10,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Shanghai Xinhua hospital","RECRUITING","Shanghai","200000","China","CN",{"type":59,"coordinates":60},"Point",[61,62],121.45806,31.22222,{"lat":62,"lon":61},[65],{"name":42,"role":47,"phone":48,"phoneExt":10,"email":49},{"type":44,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Lai Jiang","021-25077820","100544366","mechanism-study-of-ventilator-induced-lung-injury-in-elderly-people-100544366",false,"NCT06367946","Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.","Mechanism Study Under the Role of Tissue Kallikrein-related Peptidase 8 (KLK8)-Induced Senescence of Pulmonary Vascular Endothelial Cells in Ventilator-induced Lung Injury in Elderly People.","Inclusion Criteria:\n\n1. Lung tissues from patients with different ages:\n\n   Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3;\n2. Peripheral blood from patients with different ages and duration of mechanical ventilation:\n\nPatients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3;\n\nExclusion Criteria:\n\n1. Lung tissues from patients with different ages:\n\n   Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.\n2. Peripheral blood from patients with different ages and duration of mechanical ventilation:\n\nPatients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension\u002Fdiabetes\u002Fcoronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.","ALL",{"count":78,"type":79},1000,"ESTIMATED","OBSERVATIONAL","1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age.\n2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial\u002Fepithelial damage, age and duration of mechanical ventilation.",[83],"Ventilator-Induced Lung Injury","2024-04-11",{"date":86,"type":87},"2024-04-16","ACTUAL",{"date":89,"type":87},"2023-06-01",{"date":91,"type":79},"2027-06-30",{"name":5,"class":6},1]