[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603051":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":10,"responsibleParty":18,"collaborators":10,"id":21,"slug":22,"hasResults":23,"nctId":24,"briefTitle":25,"officialTitle":26,"acronym":27,"eligibilityCriteria":28,"healthyVolunteers":23,"sex":29,"minAge":30,"maxAge":31,"enrollmentInfo":32,"targetDuration":35,"studyType":36,"phases":10,"briefSummary":37,"conditions":38,"keywords":40,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":49,"leadSponsor":51,"locationsCount":10},{"fullName":5,"class":6},"Nanjing Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Middle-aged frail population with CKM syndrome",null,"This was a non-interventional longitudinal study，primarily focuses on the mechanisms and factors influencing physical activity in middle-aged CKM syndrome patients.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Zhongmin Fu","CONTACT","86-15120179663","15120179663@163.com",{"type":19,"investigatorFullName":14,"investigatorTitle":20,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100603051","mechanisms-and-interventions-for-physical-activity-in-frail-cardiovascular-kidney-metabolic-syndrome-patients-a-temporal-self-regulation-approach-100603051",false,"NCT07131488","Mechanisms and Interventions for Physical Activity in Frail Cardiovascular-kidney-metabolic Syndrome Patients: A Temporal Self-Regulation Approach","Research on the Mechanisms and Intervention Strategies for Physical Activity Promotion in Frail Patients With Cardiovascular-Kidney-Metabolic Syndrome From a Temporal Self-Regulation Perspective","CKM","Inclusion Criteria:\n\n* Aged ≥45 years and \\\u003C60 years;\n\nFrailty status assessed by Fried phenotype criteria, including those diagnosed with frailty or pre-frailty;\n\nMeeting AHA guideline criteria for Stage 1-2 CKM syndrome (diagnostic details in Table 1);\n\nAbility to communicate normally and use smartphones or wearable devices;\n\nWillingness to participate in surveys and follow-up;\n\nAdditional Note on PREVENT Equation:\n\nThe PREVENT equation, developed by the American Heart Association (AHA), is a cardiovascular disease (CVD) risk prediction tool. It calculates 10-year CVD risk based on:\n\nAge, sex\n\nTotal cholesterol, HDL-C\n\nSystolic blood pressure, BMI\n\neGFR\n\nHistory of diabetes, smoking\n\nUse of antihypertensive or lipid-lowering medications\n\nExclusion Criteria:\n\n* Severe cognitive impairment (e.g., MMSE score \\\u003C10 or clinical dementia diagnosis);\n\nSevere psychiatric\u002Fpsychological disorders (e.g., schizophrenia, major depressive disorder with suicidal ideation);\n\nAdvanced chronic diseases including:\n\nEnd-stage renal disease (eGFR \\\u003C15 mL\u002Fmin\u002F1.73m² or on dialysis)\n\nMetastatic cancer (stage IV per AJCC criteria)\n\nCardiorespiratory insufficiency (NYHA Class III-IV heart failure or COPD GOLD Stage D)\n\nSevere osteoarthritis (Kellgren-Lawrence Grade 4 with functional limitation)\n\nMajor surgery or acute illness within 3 months (e.g., myocardial infarction, stroke, or major trauma requiring hospitalization);\n\nPhysical disabilities impairing mobility (e.g., amputation, paralysis, or severe Parkinsonism with Hoehn \\& Yahr Stage ≥3).","ALL","45 Years","60 Years",{"count":33,"type":34},614,"ESTIMATED","9 Months","OBSERVATIONAL","Longitudinal physical activity data and associated factors were collected at baseline (diagnosis), 3-month, 6-month, and 9-month follow-ups in cardiovascular-kidney-metabolic syndrome patients.",[39],"Cardiovascular-kidney-metabolic Syndrome",[41,42],"Time-limited Self-regulation Theory","physical activity","NOT_YET_RECRUITING","2025-08-12",{"date":46,"type":47},"2025-08-20","ACTUAL",{"date":46,"type":34},{"date":50,"type":34},"2026-10-12",{"name":5,"class":6}]