[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624365":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":33,"centralContacts":33,"locations":38,"responsibleParty":63,"collaborators":33,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":33,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":90,"whyStopped":33,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Oslo","OTHER",[8,14,18,23],{"label":9,"type":10,"description":11,"interventionNames":12},"CBT once weekly","EXPERIMENTAL","The patients in this arm will receive CBT once a week in 16 weeks plus three monthly boosters during 3 months",[13],"Behavioral: Cognitive behavior therapy",{"label":15,"type":10,"description":16,"interventionNames":17},"CBT twice weekly","The patients in this arm will receive CBT twice a week in 8 weeks plus three booster sessions every second week three times.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"STPP once weekly","The patients in this arm will receive STPP once a week in 28 weeks.",[22],"Behavioral: Psychodynamic therapy",{"label":24,"type":10,"description":25,"interventionNames":26},"STPP twice weekly","The patients in this arm will receive STPP twice a week in 14 weeks.",[22],[28,34],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"BEHAVIORAL","Cognitive behavior therapy","The study explores cognitive behavior therapy and psychodynamic therapy",[9,15],null,{"type":29,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Psychodynamic therapy","The patients will receive psychodynamic therapy",[19,24],[39],{"facility":40,"status":33,"city":41,"state":42,"zip":43,"country":42,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Oslo University Hospital","Oslo","Norway","Postboks 4959","NO",{"type":46,"coordinates":47},"Point",[48,49],10.74609,59.91273,{"lat":49,"lon":48},[52,57,61],{"name":53,"role":54,"phone":55,"phoneExt":33,"email":56},"Jan Ivar Røssberg, Professor","CONTACT","+47 47876866","j.i.rossberg@medisin.uio.no",{"name":58,"role":54,"phone":59,"phoneExt":33,"email":60},"Randi Ulberg, Professor","+47 95883479","randi.ulberg@medisin.uio.no",{"name":53,"role":62,"phone":33,"phoneExt":33,"email":33},"PRINCIPAL_INVESTIGATOR",{"type":62,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":40,"oldNameTitle":33,"oldOrganization":33},"Jan Ivar Rossberg","Professor","100624365","mechanisms-of-change-in-psychotherapy-the-effects-of-cognitive-behavioral-therapy-and-psychodynamic-therapy-in-once---versus-twice---weekly-sessions-on-outcomes-in-depression-100624365",false,"NCT07408687","Mechanisms Of Change in Psychotherapy: The Effects of Cognitive Behavioral Therapy and Psychodynamic Therapy in Once - Versus Twice - Weekly Sessions on Outcomes in Depression.","MOP II","Inclusion criteria:\n\n* age 18-65 years\n* Major Depressive Disorder Hamilton Depression Rating Scale (HDRS) \\> 14.\n* Speak and understand a Scandinavian language\n* Willingness and ability to give informed consent.\n\nExclusion Criteria:\n\n* Current or past neurological illness\n* Traumatic brain injury\n* Current alcohol and\u002For substance dependency disorders\n* Psychotic disorders\n* Bipolar disorders\n* Developmental disorders\n* IQ \\\u003C70.","ALL","18 Years","65 Years",{"count":77,"type":78},200,"ESTIMATED","INTERVENTIONAL",[81],"NA","The MOP II study examines how to improve therapy for people struggling with a depressive disorder. Cognitive Behavioral Therapy (CBT) and Short-Term Psychodynamic Psychotherapy (STPP) are two evidence-based treatments for depression that are widely used. Meta-analyses indicate that CBT and STPP are one average equally effective and superior to no treatment. However, many patients do not respond sufficiently and relapse rates after acute phase treatment are high.\n\nEarlier research and theoretical insights suggest three promising strategies to enhance the effectiveness of psychotherapy. First, we want to examine whether increasing the frequency of the sessions will increase the effect of therapy. We want to compare once-weekly and twice-weekly sessions in both CBT and STPP to see whether more frequent sessions lead to better and more lasting reductions in depressive symptoms with the same total number of sessions.\n\nSecond, the study aims to answer what works for whom in two different psychotherapeutic approaches. People with depression differ in personality, life experiences, relationship styles, and how they understand the causes of their depression. Previous findings suggest that patients do better when the therapy approach matches how they see their problems. The MOP II study wants to replicate this finding.\n\nThird, the study wants to examine how therapy leads to change. In CBT, improvement is thought to happen through changes in thinking patterns, such as fewer negative automatic thoughts and less rumination. In STPP, change is expected to come from better self-understanding, greater emotional awareness, and healthier ways of relating to others.\n\nConsequently, the goal of the MOP II study is to find out whether more frequent therapy, better matching of patients to treatment type, and a clearer understanding of how therapy works can lead to faster improvement of depressive symptoms.",[84,85,86],"Depression - Major Depressive Disorder","Cognitive Behavior Therapy","Psychodynamic Therapy",[88,89],"Mechanisms of change in Psychotherapy","Frequency of therapy sessions","NOT_YET_RECRUITING","2026-02-13",{"date":93,"type":94},"2026-02-18","ACTUAL",{"date":96,"type":78},"2026-03-01",{"date":98,"type":78},"2030-12-31",{"name":5,"class":6},1]