[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588550":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":42,"centralContacts":46,"locations":51,"responsibleParty":68,"collaborators":28,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":28,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":28,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":54,"whyStopped":28,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"CBT+dTMS treatment group","EXPERIMENTAL","CBT+dTMS treatment group has 55 patients. Each patient receives 12 individual sessions of CBT for 50 minutes 2 times per week for 6 weeks. dTMS intervention use real coils, targeting ACC, given 5 times per week (Monday to Friday) for 6 consecutive weeks.",[13,14,15],"Device: Deep transcranial magnetic stimulation","Behavioral: cognitive behavior therapy","Other: Basic treatment",{"label":17,"type":18,"description":19,"interventionNames":20},"CBT+pseudo-stimulation group","ACTIVE_COMPARATOR","CBT+Pseudo-stimulation group has 55 patients. Each patient receives 12 individual sessions of CBT for 50 minutes 2 times per week for 6 weeks. dTMS intervention uses sham coils (with the same parameters as real dTMS and generating the same noise as real coils, but without the magnetic field). It is given 5 times per week (Monday to Friday) for 6 consecutive weeks.",[14,21,15],"Device: Sham deep transcranial magnetic stimulation",[23,29,34,38],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DEVICE","Deep transcranial magnetic stimulation","M-100 Ultimate pulsed magnetic field stimulator is used for dTMS treatment. The coil is positioned 4 cm anterior to the scalp point and the foot motor cortex, corresponding to the ACC. A naturally cold HF001A coil is used to obtain a greater depth of stimulation, up to about 6 cm subcortical. The coil is an integrated coil for true and false stimulation loops. The intervention protocol is as follows: 30 treatments are given 5 times per week (Monday to Friday) for 6 consecutive weeks. Intervention mode: stimulation frequency 20Hz, stimulation intensity 100% RMT, number of serial pulses 50, sequence interval 20s, a total of 40 trials, 2000 pulses, stimulating the left and right ACC respectively.",[9],null,{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":28},"BEHAVIORAL","cognitive behavior therapy","Each patient receives 12 individual sessions of 50 minutes twice a week for 6 weeks.The CBT therapists are nationally registered psychotherapists with systematic professional training and uniform training in CBT for anorexia nervosa to ensure consistency. They are also supervised by a CBT supervisor at the end of each session.",[9,17],{"type":24,"name":35,"description":36,"armGroupLabels":37,"otherNames":28},"Sham deep transcranial magnetic stimulation","M-100 Ultimate pulsed magnetic field stimulator is used for dTMS treatment. The coil is positioned 4 cm anterior to the scalp point and the foot motor cortex, corresponding to the ACC (The sham coil has the same parameters as real dTMS and generating the same noise as real coils, but without the magnetic field). A naturally cold HF001A coil is used to obtain a greater depth of stimulation, up to about 6 cm subcortical. The intervention protocol is as follows: 30 treatments are given 5 times per week (Monday to Friday) for 6 consecutive weeks. Intervention mode: stimulation frequency 20Hz, stimulation intensity 100% RMT, number of serial pulses 50, sequence interval 20s, a total of 40 trials, 2000 pulses, stimulating the left and right ACC respectively.",[17],{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":28},"Basic treatment","According to national and international guidelines for the treatment of eating disorders, the basic treatment for patients is nutritional therapy, that is, regular and quantitative dietary treatment, with three regular meals followed by a snack meal 2 hours after the regular meal. Both groups received the same nutritional treatment.",[9,17],[43],{"name":44,"affiliation":5,"role":45},"Jue Chen, PHD","PRINCIPAL_INVESTIGATOR",[47],{"name":44,"role":48,"phone":49,"phoneExt":28,"email":50},"CONTACT","+8618017311203","chenjue2088@163.com",[52],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Shanghai Mental Health","RECRUITING","Shanghai","Shanghai Municipality","200030","China","CN",{"type":61,"coordinates":62},"Point",[63,64],121.45806,31.22222,{"lat":64,"lon":63},[67],{"name":44,"role":48,"phone":49,"phoneExt":28,"email":50},{"type":45,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Jue CHEN","Director of Psychosomatic Department in Shanghai Mental Health Center","100588550","mechanisms-of-deep-transcranial-magnetic-stimulation-in-enhancing-cognitive-behavioral-therapy-for-anorexia-nervosa-100588550",false,"NCT06942858","Mechanisms of Deep Transcranial Magnetic Stimulation in Enhancing Cognitive-Behavioral Therapy for Anorexia Nervosa","Mechanisms of Deep Transcranial Magnetic Stimulation Enhances the Efficacy of Cognitive-behavioral Therapy (CBT) by Modulating Anterior Cingulate Cortex in Patients With Anorexia Nervosa","Inclusion Criteria:\n\n* Inclusion Criteria:\n* Female, aged 18-35 years, right handedness.\n* Above primary education.\n* Meet the diagnostic criteria of AN in DSM-V, and13.0 kg\u002Fm2 ≤ body mass index (BMI)\\\u003C18.5 kg\u002Fm2.\n* No systemic nutritional therapy, psychiatric medication or any form of psychotherapy have been received within 1 month before enrollment.\n* Able to understand the nature of this study and sign an informed consent form.\n\nExclusion Criteria:\n\n* Diagnosed with a DSM-5 disease other than anorexia nervosa, or at high risk of suicide, strong impulsive behavior as well as anti-social behavior.\n* With severe physical or cognitive impairment.\n* Not able to undergo MRI.\n* Considered unsuitable for enrollment in this clinical trial for other reasons.","FEMALE","18 Years","35 Years",{"count":82,"type":83},110,"ESTIMATED","INTERVENTIONAL",[86],"NA","The goal of this clinical trial is to learn if dTMS targeting the ACC can be used to rapidly and effectively treat AN. A randomized controlled study design is adopted, in which patients with AN are divided into the CBT+dTMS treatment group and CBT+pseudostimulation group by 1:1 randomization, followed by a 6-week intervention and a half-year follow-up to clarify whether CBT combined with dTMS is superior to single CBT treatment for AN.",[89],"Feeding and Eating Disorders",[91,25,92],"anorexia nervosa","anterior cingulate cortex","2025-05-06",{"date":95,"type":96},"2025-05-11","ACTUAL",{"date":98,"type":83},"2025-04-30",{"date":100,"type":83},"2028-12-31",{"name":5,"class":6},1]