[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100492384":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":45,"responsibleParty":64,"collaborators":67,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":43,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":43,"overallStatus":47,"whyStopped":43,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Oregon","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sleep extension and advance \"Lark Routine\"","EXPERIMENTAL","Participants go to bed 90 minutes earlier than their typical average bedtime to extend sleep duration and advance sleep timing",[13],"Behavioral: Sleep extension and advance",{"label":15,"type":16,"description":17,"interventionNames":18},"Regular sleep duration and timing \"Owl Routine\"","ACTIVE_COMPARATOR","Participants go to bed at their typical average bedtime",[19],"Behavioral: Regular sleep duration and timing",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Sleep extension and advance","Participants in the sleep extension and advance condition will maintain a stable sleep schedule that extends sleep duration and advances bedtime by 90 min relative to weekday bedtime. This chronotherapeutic manipulation will include blocking phase-delaying light in the evening using goggles with orange lenses (\"blue blockers\") beginning 2 h prior to bedtime, and 30 min of 506 lux blue-green light exposure in the morning beginning at rise time using bright light goggles (ReTimer Pty Ltd., Australia). Schedule and chronotherapy adherence will be reinforced using motivational techniques (e.g., securing motivation, preplanning, problem-solving), requiring participants to text the study coordinator and complete morning assessments at rise time, and monetary incentives.",[9],[27],"Lark routine",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Regular sleep duration and timing","Participants in the regular sleep duration and timing condition will keep a stable sleep schedule that matches their typical weekday sleep opportunity and timing. Schedule adherence will be reinforced using motivational techniques (e.g., securing motivation, preplanning, problem-solving), requiring participants to text the study coordinator and complete morning assessments at rise time, and monetary incentives.",[15],[33],"Owl routine",[35],{"name":36,"affiliation":5,"role":37},"Melynda D Casement, PhD","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Amanda Johnson","CONTACT","541-346-4107",null,"anj@uoregon.edu",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Eugene","Oregon","97403","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-123.08675,44.05207,{"lat":57,"lon":56},[60],{"name":61,"role":41,"phone":62,"phoneExt":43,"email":63},"Melynda D Casement","5413467051","casement@uoregon.edu",{"type":37,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Melynda Casement","Associate Professor of Psychology",[68,70,72],{"name":69,"class":6},"Oregon Research Institute",{"name":71,"class":6},"University of Pittsburgh",{"name":73,"class":74},"National Institute of Mental Health (NIMH)","NIH","100492384","mechanisms-of-depression-and-anhedonia-in-adolescents-linking-sleep-to-reward--and-stress-related-brain-function-100492384",false,"NCT05691439","Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function","Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function","MoDA","Inclusion Criteria:\n\n1. 14-18 years of age\n2. Currently in high school\n3. short and late sleep (weekday sleep duration ≤ 7 h and bedtime ≥ 22:30 (10:30 pm); n=100) or long and early sleep (weekday sleep duration \\> 7 hours and bedtime ≤ 22:30 (10:30 pm); n=50), indexed by the Munich Chronotype Questionnaire\n4. Lifetime stressful event frequency ≥ 2 on the Stress and Adversity Inventory (STRAIN) Screener\n5. Depressive symptom severity t-score greater than or equal to 45 on the Patient Reported Outcomes (PROMIS) Depression scale\n6. English language fluency\n\nExclusion Criteria:\n\n1. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for current moderate to severe alcohol\u002Fsubstance use disorder (≥4 symptoms);\n2. Current clinician-provided diagnosis of narcolepsy or idiopathic hypersomnia;\n3. Lifetime diagnosis of bipolar or schizophrenia spectrum disorder;\n4. Certain medical conditions (e.g., serious neurological disorder, heart failure or serious heart trouble, history of head injury with unconsciousness \\> 5 minutes);\n5. Conditions that are contraindicated for magnetic resonance imaging (MRI; e.g., ferrous metal in the body);\n6. Positive screen for participant-reported eye disease, epilepsy, or photosensitizing medications that are contraindicated during the manipulation condition when bright light is administered (e.g., psychiatric neuroleptic drugs \\[e.g., phenothiazine\\], psoralen drugs, antiarrhythmic drugs \\[e.g., amiodarone\\], antimalarial and antirheumatic drugs, porphyrin drugs used in photodynamic treatment of skin diseases);\n7. Use of melatonin if participant is not willing to discontinue use for the duration of the study.\n\nWe will schedule around (i.e., delay appointments as needed) to avoid the timeframe of the following events:\n\n1. urgent suicide risk, defined by moderate\u002Fsevere risk per Columbia Suicide Severity Rating Scale (CSSRS) and clinician determination that current risk requires immediate action;\n2. travel across two or more time zones within the month prior to the overnight study visits;\n3. beginning or ending a prescribed medication within 2 months of the observational study;\n4. prescribed medication dose changes within the timeframe calculated as 5x the drug's half-life \\[the time to reach pharmacokinetic steady-state\\] before the initiation of the observational or experimental studies;\n5. anticipated change in prescribed medications or medication dosing during the observational or experimental studies;\n6. current symptoms of airborne infectious illness prior to laboratory visits.\n\nParticipants with positive breathalyzer screen (blood alcohol level \\> .02) will be rescheduled for an alternative overnight visit date.","ALL","14 Years","18 Years",{"count":87,"type":88},150,"ESTIMATED","INTERVENTIONAL",[91],"NA","This research will use biobehavioral approaches to generate understanding about the linkages between sleep duration and timing, stressful life events, and depressive symptoms in adolescents, with a long-term aim of developing effective preventative interventions.",[94],"Depression in Adolescence","2025-11-13",{"date":97,"type":98},"2025-11-17","ACTUAL",{"date":100,"type":98},"2023-03-27",{"date":102,"type":88},"2026-12-31",{"name":5,"class":6},1]