[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100396465":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":55,"collaborators":59,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":23,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":23,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":38,"whyStopped":23,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Exercise","EXPERIMENTAL","Low-load knee extension resistance training (20% of 1-RM) without blood flow restriction. A 10-cm wide inflatable cuff will be placed around the upper portion of the thigh but not inflated.",[13],"Other: Control Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Blood Flow Restriction Exercise","Low-load knee extension resistance training (20% of 1-RM) with blood flow restriction using a 10-cm wide inflatable cuff placed around the most proximal part of the exercising thigh. Blood flow will be restricted in the BFR leg at above the limb occlusion pressure of the and this will be determined prior to the exercise while the participant is seated in the knee extensor machine. The cuff pressure during the BFR protocol will be 10 mmHg above limb occlusion pressure.",[18],"Other: Blood Flow Restriction Exercise",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"Each participant will attend 3 sessions per week for 8 weeks. Participants will perform low-load knee extension resistance training (20% of 1-RM) without blood flow restriction on the designated leg for 4 sets of contractions with 15 contractions per set of contractions with a 30 second rest between each set of contractions.",[9],null,{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":23},"Each participant will attend 3 sessions per week for 8 weeks. Participants will perform low-load knee extension resistance training (20% of 1-RM) with blood flow restriction on the designated leg for 4 sets of contractions with 15 contractions per set of contractions with a 30 second rest between each set of contractions.",[15],[28,33],{"name":29,"role":30,"phone":31,"phoneExt":23,"email":32},"Sandra Hunter, PhD","CONTACT","(734) 647-9819","sandrahu@umich.edu",{"name":34,"role":30,"phone":23,"phoneExt":23,"email":35},"Sarah Lessila, MSc","slessila@umich.edu",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Ann Arbor","Michigan","48109","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-83.74088,42.27756,{"lat":48,"lon":47},[51,52],{"name":29,"role":30,"phone":31,"phoneExt":23,"email":32},{"name":53,"role":30,"phone":54,"phoneExt":23,"email":35},"Sarah Lessila, MS","(734) 647-6019",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Sandra Hunter","Francie Kraker Goodridge Collegiate Professor of Kinesiology and Professor of Kinesiology, School of Kinesiology",[60,62,64,66,69],{"name":61,"class":6},"University of Illinois at Chicago",{"name":63,"class":6},"Medical College of Wisconsin",{"name":65,"class":6},"University of Wisconsin, Madison",{"name":67,"class":68},"National Institute on Aging (NIA)","NIH",{"name":70,"class":6},"Marquette University","100396465","mechanisms-of-fatigability-with-diabetes-100396465",false,"NCT04442451","Mechanisms of Fatigability With Diabetes","Mechanisms of Fatigability and the Protective Effects of Exercise in People With Diabetes","Inclusion Criteria:\n\n* Men and women adults 30 years to 85 years or less\n* Pre-diabetes \\[glycosylated hemoglobin (HbA1c) of 5.7-6.4% and fasting plasma glucose 100-125 mg\u002FdL at the time of initial screening\\]\n* Controls \\[normoglycemic with a HbA1c level ≤5.6% and fasting blood glucose ≤ 99 mg\u002FdL (5.5 mmol\u002FL)\\]\n* Type 2 Diabetes Mellitus \\[elevated glycosylated hemoglobin (HbA1c) \\>6.5% and \\\u003C10%\\]\n\nExclusion Criteria:\n\n* Signs or symptoms of neuropathy\n* Medications associated with advanced stages of T2D including insulin\n* Poor glycemic control (HbA1c\\>10%)\n* Peripheral edema\n* Severe obesity (BMI, \\>45kg·m-2)\n* Untreated hypothyroidism\n* Smoking\n* Hypertension\n* Cardiovascular or musculoskeletal disease that preclude exercise testing\n* Hormone replacement drugs or vasoactive medications","ALL","30 Years","85 Years",{"count":82,"type":83},80,"ESTIMATED","INTERVENTIONAL",[86],"NA","Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance. The cause for the increased fatigability in people with Pre-D is not known. Given the profound vascular disease present in people who have had uncontrolled diabetes for several years, we will determine whether dynamic, fatiguing contractions of the lower limb muscles in people with Pre-D are limited by vascular dysfunction at multiple levels along the vascular tree including the artery, arteriole, and\u002For capillary. This clinical trial involves a novel exercise training regime involving blood flow restriction to the exercising limb will be used as a probe to further understand the vascular mechanisms for increased fatigability in people with Pre-D and T2D. The long-term goal is to better understand what limits exercise and functional performance in people with diabetes to help develop targeted, more effective exercise programs.",[89,90],"Pre-diabetes","Type 2 Diabetes",[92,89,93,94,95,96],"Diabetes","Fatigability","Blood Flow Restriction Training","Vascular Function","Muscle Fatigue","2025-10-06",{"date":99,"type":100},"2025-10-08","ACTUAL",{"date":102,"type":100},"2022-09-01",{"date":104,"type":83},"2027-08-31",{"name":5,"class":6},1]