[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615806":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":29,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":51,"sex":55,"minAge":56,"maxAge":10,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Women undergoing IVF and early pregnancy",null,"This cohort includes women undergoing in vitro fertilization (IVF)",[13],"Other: Blood sampling",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Blood sampling","Blood samples will be analyzed before and during early pregnancy as well as after early miscarriage",[9],[20],{"name":21,"affiliation":22,"role":23},"Ursula Gobrecht-Keller, MD","University Hospital of Basel","STUDY_DIRECTOR",[25],{"name":21,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","+41 61 265 93 37","ursula.gobrecht@usb.ch",[30],{"facility":31,"status":32,"city":33,"state":10,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"University Hospital Basel","RECRUITING","Basel","4031","Switzerland","CH",{"type":38,"coordinates":39},"Point",[40,41],7.57327,47.55839,{"lat":41,"lon":40},[44,45],{"name":21,"role":26,"phone":27,"phoneExt":10,"email":28},{"name":21,"role":46,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100615806","mechanisms-of-maternal-immune-tolerance-in-early-pregnancy-100615806",false,"NCT07297394","Mechanisms of Maternal Immune Tolerance in Early Pregnancy","Inclusion Criteria:\n\nBlood from patients will be included before and during pregnancies (or failed implantation) conceived through IVF\u002FICSI (Intracytoplasmic Sperm Injection) treatment and in case of miscarriage.\n\n1. where the patient (pregnant person) was ≥ 18 years of age.\n2. where the patient (pregnant person) signed a written informed consent.\n\nExclusion Criteria:\n\n1. Certain maternal infections (HIV, Hepatitis B, Hepatitis C, Syphilis)\n2. Patients under immunosuppressive medications (at time of blood sample collection)","FEMALE","18 Years",{"count":58,"type":59},100,"ESTIMATED","OBSERVATIONAL","This study explores the mechanisms of maternal immune tolerance in early pregnancy by characterizing immune cell profiles and functional pathways during the first trimester. The goal is to identify immunological factors that support healthy gestation and prevent complications such as miscarriages.",[63,64,65],"Pregnancy","Immune Tolerance","In Vitro Fertilization",[67,68,69,70,71],"Maternal Immune Tolerance","Early Pregnancy","Immune Regulation","T cells","Cytokines","2026-03-03",{"date":74,"type":75},"2026-03-04","ACTUAL",{"date":77,"type":75},"2026-03-02",{"date":79,"type":59},"2030-12",{"name":5,"class":6},1]