[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589183":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":7,"locations":13,"responsibleParty":33,"collaborators":35,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":7,"enrollmentInfo":50,"targetDuration":7,"studyType":53,"phases":7,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":16,"whyStopped":7,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"University of Edinburgh","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","CT coronary angiography","To assess the presence of obstructive coronary artery disease, participants will either have coronary angiography as part of their routine care or they will return for a research CT scan of their heart (CT Coronary Angiogram)",[14],{"facility":15,"status":16,"city":17,"state":18,"zip":7,"country":19,"countryCode":20,"cosmosGeoPoint":21,"geoPoint":26,"contacts":27},"Royal Infirmary of Edinburgh","RECRUITING","Edinburgh","East of England","United Kingdom","UK",{"type":22,"coordinates":23},"Point",[24,25],-3.19648,55.95206,{"lat":25,"lon":24},[28],{"name":29,"role":30,"phone":31,"phoneExt":7,"email":32},"Elizabeth Highton-Williamson","CONTACT","0131 242 6431","ehighton@ed.ac.uk",{"type":34,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[36,38],{"name":37,"class":6},"British Heart Foundation",{"name":39,"class":40},"NHS Lothian","OTHER_GOV","100589183","mechanisms-of-myocardial-injury-and-ischemia-in-patients-with-rapid-atrial-fibrillation-100589183",false,"NCT06951100","Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation","Mi-AF","Inclusion Criteria:\n\n1. Age 18 years and over\n2. Primary presentation with symptoms related to atrial fibrillation\n3. Atrial fibrillation with a ventricular rate \\>100 bpm on a 12-lead electrocardiogram\n4. Able to provide informed consent\n\nExclusion Criteria\n\n1. Previous myocardial infarction\n2. Previous coronary revascularisation procedure\n3. Patients in renal failure (eGFR \\\u003C30ml\u002Fmin\u002F1.73m2) or major allergy to contrast media\n4. Pregnancy or breast feeding\n5. Deemed unsuitable for participation in the study by the attending clinician\n6. Previous enrolment in the trial","ALL","18 Years",{"count":51,"type":52},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF)\n\nThe main questions this study aims to answer are:\n\n1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease)\n2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia\n\nTo do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)",[56],"Atrial Fibrillation (AF)",[58,59,60,61,62,63],"Atrial Fibrillation","Cardiology","Emergency Medicine","Myocardial Infarction","Myocardial Ischemia","Coronary Artery Disease","2026-06-12",{"date":66,"type":67},"2026-06-15","ACTUAL",{"date":69,"type":67},"2025-05-01",{"date":71,"type":52},"2029-10",{"name":5,"class":6},1]