[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100347632":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":51,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":10,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1 no Preeclampsia",null,"Cohort 1: mothers with no diagnosis of preeclampsia during pregnancy Omental Biopsy and placental collection will be performed",[13],"Procedure: Omental Biopsy",{"label":15,"type":10,"description":16,"interventionNames":17},"Cohort 2 mild or severe Preeclampsia","Cohort 2: mothers with diagnosis of mild or severe preeclampsia during pregnancy Omental Biopsy and placental collection will be performed",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","Omental Biopsy","The surgeon and clinical care team will conduct the c-section to deliver the baby and the placenta as clinically indicated. After delivery, during the closing procedures, the surgeon will indicate a time for a participating Ob\u002FGyn physician on the study team to collect the omental bio-specimen. Omentum is frequently excised or removed for clinical reasons during surgical procedures. Omentum has small blood vessels within it that have been used for evaluation of vascular functional changes in research. The investigators wish to isolate one to three vessels of 5 to 7 cm length. The surgeon will then close and the clinical care team will resume their standard of care activities.",[9,15],[25],{"name":26,"affiliation":5,"role":27},"Sathish Kumar, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"UW Ob\u002FGyn Human Subjects Core","CONTACT","608-890-3345","research.crc_obgyn@wisc.edu",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"UnityPoint Health-Meriter Hospital","RECRUITING","Madison","Wisconsin","53715","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-89.40123,43.07305,{"lat":47,"lon":46},[50],{"name":26,"role":27,"phone":10,"phoneExt":10,"email":10},{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[54],{"name":55,"class":56},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100347632","mechanisms-of-pregnancy-vascular-adaptations-100347632",false,"NCT03806283","Mechanisms of Pregnancy Vascular Adaptations","Angiotensin 2 Receptor (AT2R) Expression\u002FActivation in Endothelial Cells in Preeclampsia","Inclusion Criteria:\n\n* Female\n* Ages 18 to 40 years old\n* Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent\n* Undergoing caesarean section, either planned or otherwise with or without trial of labor\n\nExclusion Criteria:\n\n* Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.\n* Any major fetal structural anomalies or aneuploidies\n* Undergoing cesarean section for placental abruption or bleeding complications.\n* Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)",true,"FEMALE","18 Years","40 Years",{"count":69,"type":70},166,"ESTIMATED","OBSERVATIONAL","The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression\u002Factivation of the AT2R.",[74,75],"Pre-Eclampsia","Vascular Diseases","2026-01-15",{"date":78,"type":79},"2026-01-20","ACTUAL",{"date":81,"type":79},"2018-11-20",{"date":83,"type":70},"2027-04",{"name":5,"class":6},1]