[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100492748":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":42,"centralContacts":46,"locations":55,"responsibleParty":72,"collaborators":37,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":37,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":37,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":37,"overallStatus":57,"whyStopped":37,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Medical College of Wisconsin","OTHER",[8,15,19,23,27],{"label":9,"type":10,"description":11,"interventionNames":12},"GERD patients with complaint of regurgitation and supra-esophageal reflux disease (SERD)","ACTIVE_COMPARATOR","GERD patients with complaint of regurgitation and one of the following supra-esophageal symptoms attributed to reflux of gastric content: chronic cough, frequent throat clearing, history of non-deglutitive aspiration pneumonia, hoarse voice, chronic sinusitis and dental erosion i.e. SE-GERD. Patients will undergo endoscopic evaluation of reflux and upper esophageal sphincter (UES) manometric testing.",[13,14],"Diagnostic Test: Concurrent manometry\u002Fimpedance\u002FpH with video pharyngo-laryngoscopy","Diagnostic Test: Slow and rapid intra-esophageal infusion",{"label":16,"type":10,"description":17,"interventionNames":18},"Age and gender matched healthy controls","Controls will undergo endoscopic evaluation of reflux and upper esophageal sphincter (UES) manometric testing.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Age and gender matched patient controls (GERD without regurgitation and supra-esophageal complaint)","Age and gender matched patient controls (GERD without regurgitation and supra-esophageal complaint). Patients will undergo endoscopic evaluation of reflux and upper esophageal sphincter (UES) manometric testing.",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Asthma patients with and without supra-esophageal symptoms","Asthma patients with and without supra-esophageal symptoms (these symptoms include chronic cough, frequent throat clearing, history of non-deglutitive aspiration pneumonia, hoarse voice, chronic sinusitis, and dental erosion). Patients will undergo endoscopic evaluation of reflux and upper esophageal sphincter (UES) manometric testing.",[13,14],{"label":28,"type":10,"description":29,"interventionNames":30},"Age and gender matched patient controls for diagnosed Barrett's esophagus patients","Patient controls for diagnosed Barrett's esophagus patients. Patients will undergo endoscopic evaluation of reflux and upper esophageal sphincter (UES) manometric testing.",[13,14],[32,38],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"DIAGNOSTIC_TEST","Concurrent manometry\u002Fimpedance\u002FpH with video pharyngo-laryngoscopy","Combined manometric\u002Fimpedance\u002FpH recording: we will use combined solid-state high-resolution manometry and impedance catheter with 36 circumferential pressure sensors, spaced 1 cm apart, 18 impedance sensor couplets spaced 2 cm apart, 3 pH sensors spaced 7 and 10 cm respectively. The catheter will be introduced trans-nasally.\n\nConcurrent video-pharyngo-laryngoscopy: to monitor concurrently the pharynx and larynx for entry of simulated refluxate we will use a laryngo-pharyngo-scope passed through the other nostril and positioned within the pharynx such that the UES inlet, vocal cords and pyriform sinuses are visualized. The laryngo-pharyngo-scope images will be synchronized with manometric\u002Fimpedance\u002FpH recordings by importing and superimposing the endoscopic images onto high resolution manometric recordings. A specially designed timer will be superimposed on the video images for durational analyses of endoscopic images.",[16,20,28,24,9],null,{"type":33,"name":39,"description":40,"armGroupLabels":41,"otherNames":37},"Slow and rapid intra-esophageal infusion","A 3 mm outer diameter injection tube will be placed through the nose in a fashion that the injection port will be located 5-7cm above the manometrically determined upper border of lower esophageal sphincter (LES). With this arrangement gastroesophageal reflux events will be simulated by intra-esophageal injection of body temperature1\u002F2 normal saline (its ionic nature helps impedance recording and identification of intra-esophageal distribution), 0.1 N HCl. Infused liquid will be colored green using food dye for ease of recognition of pharyngeal reflux. Esophageal clearance will be verified by the presence of an effective peristalsis and return of intra-esophageal impedance and pressure to baseline. Endoscopic views of pharynx will be watched carefully during infusions. At the first sign of reflux, perfusion will be stopped, and participants will be instructed to swallow to avoid any potential airway compromise.",[16,20,28,24,9],[43],{"name":44,"affiliation":5,"role":45},"Reza Shaker, MD","PRINCIPAL_INVESTIGATOR",[47,51],{"name":44,"role":48,"phone":49,"phoneExt":37,"email":50},"CONTACT","4149556840","rshaker@mcw.edu",{"name":52,"role":48,"phone":53,"phoneExt":37,"email":54},"Mark Kern","4148053826","mkern@mcw.edu",[56],{"facility":5,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"RECRUITING","Milwaukee","Wisconsin","53086","United States","US",{"type":64,"coordinates":65},"Point",[66,67],-87.90647,43.0389,{"lat":67,"lon":66},[70,71],{"name":44,"role":48,"phone":49,"phoneExt":37,"email":50},{"name":52,"role":48,"phone":53,"phoneExt":37,"email":54},{"type":45,"investigatorFullName":44,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"Associate Provost for Clinical and Translational Research, Senior Associate Dean and Director of the Clinical and Translational Science Institute of SE WI, and the Joseph E. Geenen Professor and Chief of Gastroenterology and Hepatology","100492748","mechanisms-preventing-pharyngeal-reflux-100492748",false,"NCT05696184","Mechanisms Preventing Pharyngeal Reflux","Pathophysiology of Pharyngo-esophageal Junction and Esophageal Mechanisms Preventing Pharyngeal Reflux of Gastric Content","Inclusion Criteria:\n\n* Age 18 to 85\n\n  * GERD patients with complaints of regurgitation and supra-esophageal symptoms will be included and recruited from our GI \\& Otolaryngology clinics\n  * GERD patients without complaint of supra-esophageal symptoms and regurgitation will be included and recruited from our GI \\& Otolaryngology clinics\n  * Asthma patients with and without supra-esophageal symptoms will be included and recruited from clinics affiliated with Medical College of Wisconsin. Asthma patients with the following classifications of asthma severity will be included: intermittent, mild persistent, moderate persistent, and severe persistent (as long as no acute asthma exacerbation at the time of the study)\n  * Patient definition will be based on position statement and technical reviews of the American Gastroenterological Association and Montreal definition and classification of gastroesophageal and reflux disease (Am J Gastroenterol. 2006;101:1900-1920).\n  * SERD is defined as patients on long term acid suppressive therapy complaining of persistent regurgitation along with supra-esophageal manifestations such as burning throat, asthma, chronic cough, or hoarseness. Patients will be screened by Reflux Symptom Index \\> 13.\n  * Barrett's esophagus patients will be recruited based on histological diagnosis from previous endoscopic biopsy that will be found using the clinical database warehouse.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>85\n\n  * Active alcohol or drug abuse\n  * History of ear, nose, throat and pulmonary diseases suspected of being GERD induced\n  * History of head and neck malignancy and chemo-radiation therapy to the head and neck\n  * Unable to give consent\n  * Pregnant women (see justification in the Women and Minority Inclusion in Clinical Research section)\n  * History of allergy to Lidocaine for nasal topical anesthesia\n  * Allergy to green food dye\n  * Asthma patients with an acute asthma exacerbation with symptoms including breathlessness, wheezing, and chest tightness",true,"ALL","18 Years","85 Years",{"count":86,"type":87},300,"ESTIMATED","INTERVENTIONAL",[90],"NA","The overall goal is to define and characterize the manometric characteristics of UES incompetence associated with objectively documented pharyngeal reflux. The investigators will use endoscopic reflux detection as gold standard.",[93],"GERD","2026-02-06",{"date":96,"type":97},"2026-02-10","ACTUAL",{"date":99,"type":97},"2013-11-01",{"date":101,"type":87},"2026-10-12",{"name":5,"class":6},1]