[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612554":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":21,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":21,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":21,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":21,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":21,"overallStatus":78,"whyStopped":21,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Aalborg University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Contagious itch","EXPERIMENTAL","A contagious itch will be induced by a video (without audio) showing people scratching.",[13,14,15],"Other: Histamine","Other: Cowhage (Mucuna Pruriens)","Other: Placebo",[17,22,26],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"Histamine","To deliver histamine, standard allergy skin prick test (SPT) lancets are applied",[9],null,{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Cowhage (Mucuna Pruriens)","The spicules will be manually inserted. Approximately 30-35 spicules are gently rubbed into a 1 cm diameter skin area on the forearm\u002Fface",[9],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":21},"Placebo","To deliver steril water, standard allergy skin prick test (SPT) lancets are applied",[9],[31],{"name":32,"role":33,"phone":34,"phoneExt":21,"email":35},"Silvia Lo Vecchio, PhD","CONTACT","+4521397785","slv@hst.aau.dk",[37],{"facility":5,"status":21,"city":38,"state":39,"zip":40,"country":39,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Gistrup","Denmark","9620","DK",{"type":43,"coordinates":44},"Point",[45,46],9.99085,56.9943,{"lat":46,"lon":45},[49,51],{"name":32,"role":33,"phone":50,"phoneExt":21,"email":35},"21397785",{"name":52,"role":33,"phone":21,"phoneExt":21,"email":53},"Giulia Erica Aliotta, PhD","gea@hst.aau.dk",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Silvia Lo Vecchio","Associate Professor","100612554","mechanisms-underlying-the-nocibo-effect-of-contagious-itch-in-both-histaminergic-and-nonhistaminergic-itch-100612554",false,"NCT07255092","Mechanisms Underlying the Nocibo Effect of Contagious Itch. in Both Histaminergic and Nonhistaminergic Itch","Pain and Itch Neuromodulation: Effects of Offset Analgesia, Placebo, and Nocebo and Topographical Distribution of Itch and Pain Receptors","Inclusion Criteria:\n\n* 18-60 years\n* Speak and understand English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other drugs\n* Previous or current history of neurological, immunological, musculoskeletal, cardiac disorder or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.)\n* Moles, wounds, scars, or tattoos in the area to be treated or tested\n* Current use of medications that may affect the trial such as antihistamines and pain killers\n* Skin diseases\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain and itch\n* Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies)\n* Contraindications to capsaicin, including intolerance to chili or burns or wounds at the application site\n* The subject is assessed as unable to engage in the necessary cooperation required by the study",true,"ALL","18 Years","60 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"NA","The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. Afterwards, three areas will be selected on each forearm of the subjects.\n\nTwo areas will be treated with histamine, two with cowhage, and two with vehicle. One application of each substance will be conducted including the contagious itch component. During the 10 minutes of the application of the pruritogens, itch and pain will be continuously monitored using a VAS scale.",[77],"ITCH","NOT_YET_RECRUITING","2025-11-27",{"date":81,"type":82},"2025-12-04","ACTUAL",{"date":84,"type":71},"2025-12-01",{"date":86,"type":71},"2028-12-31",{"name":5,"class":6},1]