[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551990":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":20,"responsibleParty":30,"collaborators":20,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":20,"eligibilityCriteria":38,"healthyVolunteers":39,"sex":40,"minAge":41,"maxAge":20,"enrollmentInfo":42,"targetDuration":20,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":20,"overallStatus":52,"whyStopped":20,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":20},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Patients will undergo cardiac imaging with a cardiac MRI and echocardiogram prior to the haemodynamic study. The haemdynamic study will be performed in the catheter lab. During that study patients will undergo a temporary pacing procedure with pacing of multiple sites of the heart and multiple haemodynamic recordings. This will be conducted under local anaesthetic and sedation. Total procedure time will be approximately 2 hours.",[13],"Diagnostic Test: Acute Haemodynamic Study",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","Acute Haemodynamic Study","Multisite temporary pacing",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Prof Christopher Aldo Rinaldi, MD, MBBS, FRCP, FHRS","CONTACT","0207188 7188","aldo.rinaldi@gstt.nhs.uk",{"name":28,"role":24,"phone":25,"phoneExt":20,"email":29},"Dr Sandra Howell, MBBS, MSc, MSc","sandra.howell@kcl.ac.uk",{"type":31,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100551990","mechanistic-insights-from-temporary-pacing-in-hfpef-100551990",false,"NCT06467266","Mechanistic Insights From Temporary Pacing in HFpEF","Mechanistic Insights From Multisite Pacing in Patients With Heart Failure With Preserved Ejection Fraction","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study.\n* Male or Female, aged 18 years or above.\n* Formal diagnosis of HFpEF as per ESC guidelines\n* NYHA grade II-IV heart failure symptoms\n* LVEF ≥50%\n* Female participants of child-bearing potential must be willing to ensure that they or their partner use effective contraception during the study and for 3 months thereafter\n* Able (in the Investigators opinion) and willing to comply with all study requirements.\n* Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study.\n\nExclusion Criteria:\n\n* History of persistent or permanent AF\n* Permanent pacing device in situ\n* Female participants who are pregnant, lactating or planning pregnancy during the course of the study.\n* Scheduled elective surgery or other procedures requiring general anaesthesia during the study.\n* Participant who is terminally ill\n* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.\n* Significant peripheral vascular disease precluding an EP study\n* A contraindication to anticoagulation\n* A prosthetic aortic, mitral or tricuspid valve\n* Significant Aortic valve disease\n* Known LV thrombus\n* Insufficient capacity to consent to the study\n* Participation in other studies with active treatment \u002F investigational arm to avoid bias",true,"ALL","18 Years",{"count":43,"type":44},10,"ESTIMATED","INTERVENTIONAL",[47],"NA","Heart failure with preserved ejection fraction (HFpEF) is characterised by impaired diastolic function. A recent clinical trial has demonstrated multiple beneficial outcomes in HFpEF patients receiving personalised accelerated pacing from indwelling permanent pacemakers, including symptomatic improvement, objective reductions in NT-proBNP level and AF-burden.\n\nThe investigators aim to determine the underlying mechanisms behind these documented effects, to investigate the acute intracardiac haemodynamic response to temporary multisite pacing in HFpEF participants and to gain further mechanistic insight with additional haemodynamic, electrical and echocardiographic data collection during temporary pacing in this cohort. This will all provide valuable information towards new potential targets of therapy.",[50,51],"Heart Failure Preserved Ejection Fraction","Pacing","NOT_YET_RECRUITING","2024-06-14",{"date":55,"type":56},"2024-06-20","ACTUAL",{"date":58,"type":44},"2024-07-01",{"date":60,"type":44},"2026-10-31",{"name":5,"class":6}]