[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577513":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":40,"collaborators":10,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":10,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Centro Cardiologico Monzino","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Amyloidosis patients (prospective cohort)",null,"Prospectively enrolled patients diagnosed with cardiac amyloidosis",{"label":13,"type":10,"description":14,"interventionNames":10},"Heart Failure patients (retrospective cohort)","Patients with history of heart failure with reduced ejection fraction previously enrolled in the MECKI score registry",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"piergiuseppe Agostoni, MD, PhD","CONTACT","0258002772","piergiuseppe.agostoni@cardiologicomonzino.it",[22],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":26,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Centro Cardiologico Monzino, Irccs","RECRUITING","Milan","Italy","20138","IT",{"type":30,"coordinates":31},"Point",[32,33],12.59836,42.78235,{"lat":33,"lon":32},[36],{"name":37,"role":18,"phone":38,"phoneExt":10,"email":39},"Piergiuseppe Agostoni","0258002010","piergiuseppe.agostoni@ccfm.it",{"type":41,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100577513","mecki-amyloidosis-assessment-of-the-exercise-capacity-and-prognosis-of-patients-with-cardiac-amyloidosis-100577513",false,"NCT06799273","MECKI-Amyloidosis: Assessment of the Exercise Capacity and Prognosis of Patients with Cardiac Amyloidosis","MECKI-AMI","Inclusion criteria\n\n* Age \\> 18 years\n* Diagnosis of cardiac amyloidosis obtained by MRI or scintigraphy\n* Ability to perform a cardiopulmonary exercise test\n\nExclusion criteria\n\n* severe obstructive pulmonary disease\n* exercise-induced angina\n* significant ECG changes\n* presence of clinical comorbidities that interfere with exercise performance","ALL","18 Years","100 Years",{"count":53,"type":54},1400,"ESTIMATED","OBSERVATIONAL","This study aims to advance the understanding of cardiac amyloidosis, its effects on exercise capacity, and its prognostic implications. By conducting a systematic investigation with particular emphasis on longitudinal evaluation, we aim to provide valuable insights to guide clinical practice and improve the management of patients with cardiac amyloidosis.\n\nOur study intends to follow patients for a period of two years, evaluating them every six months. This longitudinal approach allows us to monitor changes in exercise capacity and other relevant clinical parameters over time. Furthermore, it enables the development of a prognostic tool similar to the MECKI score, capable of assessing the risk of adverse events in patients with cardiac amyloidosis based on their exercise performance.\n\nBy comparing our results with data from heart failure patients already included in the MECKI score database, we also aim to highlight any differences in prognosis between patients with cardiac amyloidosis and those with general heart failure. Finally, we aim to characterize cardiac amyloidosis by differentiating it from general heart failure. By comparing our results with data from heart failure patients already included in the MECKI score database, we can clarify the distinct exercise limitations in cardiac amyloidosis and shed light on how they differ from more conventional heart failure.",[58],"Cardiac Amyloidosis","2025-01-23",{"date":61,"type":62},"2025-01-29","ACTUAL",{"date":64,"type":62},"2024-05-07",{"date":66,"type":54},"2027-05",{"name":5,"class":6},1]