[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100410996":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":68,"collaborators":26,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":26,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":26,"maxAge":26,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Tianjin Medical University Cancer Institute and Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mediastinal lymph node dissection group","EXPERIMENTAL","A",[13],"Procedure: Systemic mediastinal lymph node dissection",{"label":15,"type":16,"description":17,"interventionNames":18},"Spared mediastinal lymph node dissection group","ACTIVE_COMPARATOR","B",[19],"Procedure: Spared mediastinal lymph node dissection",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Systemic mediastinal lymph node dissection","Systematic hilar and mediastinal lymph node dissection.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Spared mediastinal lymph node dissection","Mediastinal lymph node is spared in this group.",[15],[32],{"name":33,"affiliation":5,"role":34},"Zhenfa Zhenfa, MD","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Zhenfa Zhang, MD","CONTACT","+862223340123","zhangzhenfa1973@163.com",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Chenguang Li, MD","+862218622819082","cgli82@yeah.net",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Ethics review board of Tianjin Medical University Cancer Institute and Hospital","RECRUITING","Tianjin","Tianjin Municipality","300060","China","CN",{"type":55,"coordinates":56},"Point",[57,58],117.17667,39.14222,{"lat":58,"lon":57},[61,65,66],{"name":62,"role":38,"phone":63,"phoneExt":26,"email":64},"Chenguang Li","+86-22-23340123","chengdongyan916@163.com",{"name":37,"role":34,"phone":26,"phoneExt":26,"email":26},{"name":42,"role":67,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"type":69,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100410996","mediastinal-lymph-node-dissection-versus-spared-mediastinal-lymph-node-dissection-in-stage-i-ggn-nsclc-100410996",false,"NCT04631770","Mediastinal Lymph Node Dissection Versus Spared Mediastinal Lymph Node Dissection in Stage I GGN NSCLC","Mediastinal Lymph Node Dissection Versus Spared Mediastinal Lymph Node Dissection in Stage IA Non-small Cell Lung Cancer Presented as Ground-glass Nodules: Study Protocol of a Phase III, Randomized, Multi-center Trial (MELDSIG) in China","Inclusion Criteria:\n\n* Thin-slice HRCT shows single GGN with C\u002FT ≤ 0.5 and no lymph node metastasis;\n* Clinical stage IA NSCLC (TNM 8th classification) diagnosed prior or in surgery;\n* No history of malignancies within past 5 years or lung surgery;\n* No anti-cancer treatment prior to surgery.\n\nExclusion Criteria:\n\n* Simultaneous or metachronous (within the past 5 years) double cancers;\n* Active bacterial or fungous infection;\n* Interstitial pneumonitis, pulmonary fibrosis, or severe pulmonary emphysema;\n* Systemic steroidal medication;\n* Uncontrollable diabetes mellitus; (vi) Uncontrollable hypertension or history of severe heart disease, heart failure.","ALL",{"count":79,"type":80},1362,"ESTIMATED","INTERVENTIONAL",[83],"NA","Lung cancer is the leading cause of cancer related death worldwide. Lobectomy or sub-lobectomy with mediastinal lymph node dissection is the standard surgery. About 50% lung nodules are pure ground-glass or part-solid nodules. Non-solid nodules rarely develop mediastinal lymph node metastasis. The present study is a prospective, multicenter and randomized clinical trial, comparing the overall survival and disease-free survival of whether performing mediastinal lymph node dissection in non-small cell lung cancer with ground-glass nodule CT features.",[86,87],"Lung Neoplasms","Lymph Node Excision",[89,90,91],"Non-small cell lung cancer","Mediastinal lymph node dissection","Ground-glass nodules","2023-09-24",{"date":94,"type":95},"2023-09-28","ACTUAL",{"date":97,"type":95},"2022-05-01",{"date":99,"type":80},"2029-05-01",{"name":5,"class":6},1]