[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642333":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":46,"collaborators":48,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of Leicester","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort A: Loin pain group",null,"This group would consist of patients with IgAN who experience loin pain episodes",{"label":13,"type":10,"description":14,"interventionNames":10},"Cohort B: No loin pain group","This group would consist of patients with IgAN who have never experienced loin pain",[16],{"name":17,"affiliation":18,"role":19},"Haresh Selvaskandan, MBChB, MRCP, MRes, PhD","University of Leicester, University Hospitals of Leicester","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Postgraduate Researcher","CONTACT","+447539398535","ik186@leicester.ac.uk",{"name":27,"role":23,"phone":10,"phoneExt":10,"email":28},"Chief Investigator","hs328@leicester.ac.uk",[30],{"facility":31,"status":10,"city":32,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"University Hospitals of Leicester","Leicester","LE1 7HA","United Kingdom","UK",{"type":37,"coordinates":38},"Point",[39,40],-1.13169,52.6386,{"lat":40,"lon":39},[43],{"name":44,"role":23,"phone":45,"phoneExt":10,"email":25},"Ishika Khan","07539398535",{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[49],{"name":50,"class":6},"University Hospitals, Leicester","100642333","mediators-of-loin-pain-in-iga-nephropathy-100642333",false,"NCT07649538","Mediators of Loin Pain in IgA Nephropathy","LO-PAIgN: Mediators of Loin Pain in Immunoglobulin-A Nephropathy","LO-PAIgN","Inclusion Criteria:\n\nCohort A\n\n1. ≥18 years of age at the time of recruitment\n2. IgAN diagnosis confirmed with a renal biopsy\n3. Episodic\u002FIntermittent Loin Pain (defined as pain at least once every 6 months)\n4. Have the capacity to consent to the study Cohort B\n\n1\\) ≥18 years of age at the time of recruitment 2) IgAN diagnosis confirmed with a renal biopsy 3) No history of loin pain 4) Have the capacity to consent to the study\n\nExclusion Criteria:\n\nCohort A\n\n1. Constant loin pain\n2. Infrequent loin pain (no pain experienced in the last 6 months)\n3. Inability to differentiate loin pain from back pain\n4. Other renal diseases\n5. Therapies that interfere with immune-mediation like steroids and complement inhibitors\n6. Kidney transplant recipients\n7. Current participation in an interventional study that may affect kidney function\n8. Patients on dialysis\n9. Patients with implants that are not MRI-safe (pacemakers, implantable defibrillators, cochlear implants, some shunts, neurostimulators, some aneurysm clips, etc.)\n\nCohort B\n\n1. Other renal diseases\n2. Therapies that interfere with immune-mediation like steroids and complement inhibitors\n3. Kidney transplant recipients\n4. Current participation in an interventional study that may affect kidney function\n5. Patients on dialysis\n6. Patients with conditions\u002Fimplants that are not MRI-compatible (claustrophobia, pacemakers, implantable defibrillators, cochlear implants, some shunts, neurostimulators, some aneurysm clips, etc.)","ALL","18 Years",{"count":62,"type":63},40,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about loin pain in people with Immunoglobulin A nephropathy (IgAN).\n\nThe main question it aims to answer is:\n\nWhat changes occur in the kidneys, urine, and blood when people with IgAN experience loin pain?\n\nParticipants will have MRI scans of their kidneys, provide urine and blood samples, and have their latest kidney function test results reviewed. For participants who experience loin pain, these assessments will be carried out during a pain episode and again when they are pain-free, so the results can be compared.",[67],"IgA Nephropathy (IgAN)",[69,70,71,72,73,74],"Kidney pain","IgAN","IgA nephropathy","Flank pain","Loin pain","Renal pain","NOT_YET_RECRUITING","2026-06-09",{"date":78,"type":79},"2026-06-16","ACTUAL",{"date":81,"type":63},"2026-08-20",{"date":83,"type":63},"2028-06-02",{"name":5,"class":6},1]