[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627220":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":22,"locations":22,"responsibleParty":23,"collaborators":25,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":21,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":22,"enrollmentInfo":42,"targetDuration":22,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":54,"overallStatus":60,"whyStopped":22,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":22},{"fullName":5,"class":6},"Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with adherence problems in antipsychotic treatment","EXPERIMENTAL","Pre-post comparison of participants identified with reduced antipsychotic medication adherence via electronic dispensing records and self-report measures will receive a structured psychoeducational adherence-support program. The intervention consists of ten online group telehealth sessions led by clinical psychologists, including two sessions with trained peer-support contributors who have lived experience of stable recovery. Sessions focus on education about illness and medication, strategies to improve adherence, problem-solving skills, digital medication management tools, and relapse-prevention planning. Participants also receive written psychoeducational materials. Duration: approximately 10 weeks, one session per week.",[13],"Behavioral: Telehealth Psychoeducational Adherence Program",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Telehealth Psychoeducational Adherence Program","Participants with reduced antipsychotic treatment adherence will receive a structured telehealth psychoeducational program designed to improve medication adherence. The program includes 10 weekly online group sessions led by clinical psychologists and two peer-support sessions, focusing on illness and medication education, adherence strategies, problem-solving, digital medication-management tools, and relapse-prevention skills. Participants also receive supportive written materials.",[9],[21],"ADHERA",null,{"type":24,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[26,28,31],{"name":27,"class":6},"Hospital Universitario Fundación Jiménez Díaz",{"name":29,"class":30},"Hospital Infanta Elena de Valdemoro, Madrid","UNKNOWN",{"name":32,"class":6},"Hospital Universitario Rey Juan Carlos","100627220","medication-adherence-in-severe-mental-illness-a-promotion-program-100627220",false,"NCT07445802","Medication Adherence in Severe Mental Illness: a Promotion Program","Therapeutic Adherence Promotion Program for Severe Mental Illness: the ADHERA Study Protocol","Inclusion Criteria:\n\n* Diagnosis established using ICD-11 clinical criteria \\[15\\].\n* Aged 18 years or older.\n* Registered on the Patient Portal.\n* With an active prescription for antipsychotic drugs in the MUP (Medication Use Profile).\n\nExclusion Criteria:\n\n* Aged under 18 years old.\n* Unable to provide consent for medical or legal reasons.\n* Not registered on the Patient Portal.\n* No active prescription for antipsychotic drugs in the MUP.","ALL","18 Years",{"count":43,"type":44},1640,"ESTIMATED","INTERVENTIONAL",[47],"NA","People living with serious mental illnesses such as schizophrenia and bipolar disorder often need long-term medication to stay well. However, many patients have difficulty taking medication regularly, which can increase the risk of relapse, hospitalization, and poorer quality of life. Traditionally, treatment adherence has been measured using self-report questionnaires, which may be influenced by memory or social desirability bias.\n\nWith the recent expansion of electronic prescription systems in Spain, it is now possible to objectively verify whether patients collect their medications from the pharmacy. This provides a new opportunity to better understand and support treatment adherence.\n\nThe ADHERA study will evaluate how well digital self-report questionnaires reflect real medication use compared with electronic dispensing records. We will also explore patient characteristics that may be associated with difficulties in medication adherence. Finally, we will test a new online psychoeducational program-including sessions led by mental health professionals and supported by peer-experience contributors-to determine whether it can help improve adherence.\n\nParticipants with schizophrenia or bipolar disorder who are registered in the hospital's digital patient portal and have active antipsychotic prescriptions will be invited to complete brief adherence questionnaires online. Individuals with signs of reduced adherence will then be invited to take part in a telehealth intervention consisting of ten group sessions, where they will receive information, support, and practical strategies to maintain their treatment plan. Medication adherence will be reassessed after six months.\n\nIf successful, this study may help improve how treatment adherence is measured in clinical practice, guide targeted interventions for individuals at higher risk of non-adherence, and provide evidence for scalable telehealth programs that can be easily implemented in other regions and medical conditions",[50,51,52,53],"Treatment Adherence and Compliance","Severe Mental Disorders","Bipolar Disorder (BD)","Schizophrenia Disorder",[55,56,57,58,59],"treatment adherence","schizophrenia","bipolar disorder","electronic health records","medication","NOT_YET_RECRUITING","2026-02-25",{"date":63,"type":64},"2026-03-03","ACTUAL",{"date":66,"type":44},"2026-09",{"date":68,"type":44},"2028-09",{"name":5,"class":6}]