[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517646":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":58,"collaborators":23,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":23,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":40,"whyStopped":23,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low melanin","EXPERIMENTAL","Individuals with skin reflectance scores below 150 using the Mexameter 18 instrument.",[13],"Other: Wear clothing that has been exposed to cigarette smoke for 3 hours.",{"label":15,"type":10,"description":16,"interventionNames":17},"High melanin","Individuals with skin reflectance scores above 249 using the Mexameter 18 instrument",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Wear clothing that has been exposed to cigarette smoke for 3 hours.","Cotton clothing is exposed to smoke from Marlboro Red (hard pack) cigarettes at 1-1.2 mg\u002Fm3 repeatedly, until total exposure equals 3 grams total particulate material. When tested after exposure, the clothing typically contained 59.15 +\u002F- 18 µg nicotine and 42 +\u002F- 24 ng NNK per gram. The mass of the clothing varies by size, but the average combination of pants and shirt contains 32 mgs nicotine and 23 µg NNK.",[15,9],null,[25],{"name":26,"affiliation":5,"role":27},"Suzaynn F Schick, PhD","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},"CONTACT","415-514-3535","suzaynn@gmail.com",{"name":34,"role":30,"phone":35,"phoneExt":23,"email":36},"Abel Huang, BS","(415) 514-9011","abel.huang@ucsf.edu",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Zuckerberg San Francisco General Hospital","RECRUITING","San Francisco","California","94110","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-122.41942,37.77493,{"lat":50,"lon":49},[53,56],{"name":54,"role":30,"phone":23,"phoneExt":23,"email":55},"Abel Huang","Abel.Huang@ucsf.edu",{"name":57,"role":27,"phone":23,"phoneExt":23,"email":23},"Suzyann Schick, PhD",{"type":59,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100517646","melanin-and-dermal-uptake-of-thirdhand-cigarette-smoke-100517646",false,"NCT06020248","Melanin and Dermal Uptake of Thirdhand Cigarette Smoke","THS05","Inclusion Criteria:\n\n* Adult nonsmoker\n* Aged 18-50\n* Skin reflectance scores below 150 or above 249 using the Mexameter 18 instrument\n* Healthy on the basis of medical history\n* Systolic blood pressure \\\u003C150\n* Diastolic blood pressure \\\u003C100\n* C-reactive protein \\\u003C3.1 mg\u002Fml\n* Liver function (AST and ALT) in normal ranges\n* kidney function (BUN) in normal ranges\n* LDL\\\u003C131\n* Blood glucose \\\u003C110\n* Not exposed to tobacco SHS.\n\nExclusion Criteria:\n\n* Dermal skin reflectance score between 150 and 249, as measured by the Mexameter 18 instrument.\n* Positive SARS-CoV-2 antibody test\n* Age 18 \\\u003C or \\> 50\n* Physician diagnosis of asthma, heart disease, hypertension, thyroid disease, diabetes, renal or liver impairment or glaucoma.\n* Unstable psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current use of more than two psychiatric medications\n* Systolic blood pressure greater than or equal to 150\n* Diastolic blood pressure greater than or equal to 100\n* Blood glucose greater than or equal to 110\n* LDL greater than or equal to130\n* Pregnancy or breastfeeding (by urine hCG and\u002For history)\n* Alcohol or illicit drug dependence within the past 5 years\n* BMI \\> 35 and \\\u003C 18\n* Current illicit drug use (by history or urine test)\n* More than 1 pack year smoking history\n* Ever a daily marijuana smoker\n* Smoked anything within the last 3 months\n* Unable to hold allergy or other OTC medicines\n* Occupational exposure to smoke, dusts OR fumes\n* Concurrent participation in another clinical trial\n* Unable to communicate in English\n* No social security number",true,"ALL","18 Years","50 Years",{"count":72,"type":73},60,"ESTIMATED","INTERVENTIONAL",[76],"NA","This is a pilot study of the effects of dermal melanin on dermal uptake and retention of nicotine. The initial hypothesis is that higher levels of dermal melanin will correlate with lower uptake and longer retention of nicotine in the skin and body.",[79],"Healthy",[81,82,83,84,85,86],"Thirdhand tobacco smoke","Dermal","Exposure","Tobacco Smoke Pollution","Melanin","Nicotine","2026-06-12",{"date":89,"type":90},"2026-06-16","ACTUAL",{"date":92,"type":90},"2023-09-01",{"date":94,"type":73},"2026-11",{"name":5,"class":6},1]