[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616597":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":39,"locations":48,"responsibleParty":69,"collaborators":73,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":26,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":26,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":50,"whyStopped":26,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Bangladesh Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental arm: Melatonin and Metformin","EXPERIMENTAL","Participants will receive Melatonin (3mg) 3 tablet single dose at night for 12 weeks and Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks",[13],"Combination Product: Melatonin 3mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Comparator arm: Metformin","ACTIVE_COMPARATOR","Participants will receive Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks",[19],"Drug: Metformin 500mg",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Metformin 500mg","Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks",[15],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"COMBINATION_PRODUCT","Melatonin 3mg","Melatonin (3mg) 3 tablet single dose at night for 12 weeks and Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks",[9],[33,36],{"name":34,"affiliation":5,"role":35},"Jesmine Banu, MS","STUDY_CHAIR",{"name":37,"affiliation":5,"role":38},"Farzana Rahman, MBBS","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":26,"email":44},"Mst.Sumyara Khatun, MS","CONTACT","+8801746046581","sumirmc09@gmail.com",{"name":37,"role":42,"phone":46,"phoneExt":26,"email":47},"+8801914229346","farzana47arshi91@gmail.com",[49],{"facility":5,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Dhaka","Shahbag","1000","Bangladesh","BD",{"type":57,"coordinates":58},"Point",[59,60],90.40744,23.7104,{"lat":60,"lon":59},[63,65,66,67],{"name":64,"role":42,"phone":43,"phoneExt":26,"email":44},"Mst Sumyara Medical officer, MS",{"name":37,"role":42,"phone":46,"phoneExt":26,"email":47},{"name":37,"role":38,"phone":26,"phoneExt":26,"email":26},{"name":34,"role":68,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Mst.Sumyara Khatun","Medical Officer",[74],{"name":5,"class":6},"100616597","melatonin--metformin-on-clinical--biochemical-parameters-in-insulin-resistant-pcos-compared-to-metformin-100616597",false,"NCT07307677","Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to Metformin","Effect of Melatonin and Metformin Combination Therapy on Clinical and Biochemical Parameters inInsulin Resistant Polycystic Ovary Syndrome Compared to Metformin Alone","Inclusion Criteria:\n\n* Diagnosed case of PCOS according to Rotterdam criteria\n* Women of age 18-35 years\n* Insulin resistance (HOMA-IR \\>2.6)\n\nExclusion Criteria:\n\n* BMI: ≤ 18.5 and ≥ 30 kg\u002Fm2\n* Uncontrolled endocrine disorders (Diabetis melitus, Hypothyroidism, Hyperprolactinemia)\n* Known case of any medical disease (Renal, hepatic or cardiac disease)\n* Any medication which would affect insulin resistance (Metformin, Myo- inositol, Pioglitazone) in last three months.\n* Hypersensitivity to melatonin.","FEMALE","18 Years","35 Years",{"count":86,"type":87},60,"ESTIMATED","INTERVENTIONAL",[90],"NA","Women with polycystic ovary syndrome with HOMA-IR \\>2.6 fulfilling inclusion and exclusion criteria will be randomly allocated into two groups:experimental group: A (Melatonin 3mg and Metformin 500mg) and control group: B (Metformin 500mg). Each group will be contained 30 selected patients.\n\nGroup B:Tab. Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks.\n\nOutcome variables will be measured after three months, will be meticulously recorded for analysis and comparison.",[93],"PCOS(Insulin Resistant)",[95],"Melatonin in PCOS","2026-01-05",{"date":98,"type":99},"2026-01-07","ACTUAL",{"date":101,"type":99},"2025-03-11",{"date":103,"type":87},"2026-08-10",{"name":71,"class":6},1]