[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631457":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":48,"collaborators":20,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":20,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":35,"whyStopped":20,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Jyvaskyla","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HRT+training","EXPERIMENTAL","The first phase follows the effect of HRT, the second phase follows the effects of HRT+physical training intervention (and compliance to the non-supervised intervention).",[13],"Behavioral: Physical training",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Physical training","A 12-week, 4 x per week (2 x strength and 2 x endurance) training program to be performed voluntarily by the participants after tests at month 2.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Simon Walker, PhD","Universirty of Jyväskylä, Finland","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Simon Walker Dr (Dos.), PhD","CONTACT","+358408054906","simon.walker@jyu.fi",[33],{"facility":34,"status":35,"city":36,"state":20,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of Jyväskylä","RECRUITING","Jyväskylä","40014","Finland","FI",{"type":41,"coordinates":42},"Point",[43,44],25.72088,62.24147,{"lat":44,"lon":43},[47],{"name":23,"role":29,"phone":30,"phoneExt":20,"email":31},{"type":25,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Simon Walker","Dr (Dos.)","100631457","menopause-effects-on-cortico-reticular-functioning-100631457",false,"NCT07500922","Menopause Effects on Cortico-reticular Functioning","Female Sex Hormone and Menopause Effects on Cortico-reticular Functioning","MENSA","Inclusion Criteria:\n\n* at least 6 months since their last period but no more than being 5 years post-menopausal\n* basal follicular-stimulating hormone concentration \\> 30 IU\u002FL (confirmed post-recruitment)\n* willing to start combined hormonal treatment\n* womb and ovaries intact with normal functioning throughout reproductive age\n* willing to provide informed consent\n* does not have any of the exclusion criteria for TMS measurements according to Rossi et al. (2021 Clin Neurophysiol. 132(1):269-306.) (i.e. arterial hypertension, heart attack\u002Fseizure history, migraine, pacemaker or cochlear implant or other implanted metal\u002Felectronic device)\n\nExclusion Criteria:\n\n* classified as excessively obese via BMI assessment (i.e., \\>35 kg\u002Fm2)\n* intra-uterine device usage during transition to menopause\n* cardiovascular or skeletomuscular disease preventing strenuous physical activity\n* smoker\n* diagnosed psychiatric illness\n* epilepsy\n* other diagnosed injuries\u002Fillness affecting the neuromuscular system","FEMALE","50 Years","59 Years",{"count":63,"type":64},20,"ESTIMATED","INTERVENTIONAL",[67],"NA","Post-menopausal women who request to begin hormone-replacement therapy (HRT) are directed to the research team. The participants are tested before beginning HRT, after two months of HRT, and five months of HRT. Tests include strength performance, central nervous system functioning, body composition, resting metabolic rate, and vascular screening. The participants are provided a 12-week training intervention (2 x strength, 2 x endurance per week) that can be voluntarily followed between tests at month 2 and 5. Compliance with the training program is recorded. A minimum of 15 participants are needed a priori, but the investigators aim to recruit and test 20 women.",[70,71],"Menopause","Hormone Replacement Therapy",[73,74,75,76],"cortico-reticular","central nervous system","physical performance","strength","2026-04-27",{"date":79,"type":80},"2026-05-01","ACTUAL",{"date":82,"type":80},"2026-04-25",{"date":84,"type":64},"2028-03-31",{"name":5,"class":6},1]