[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606830":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Volunteers",null,"Single group design",[13],"Device: transcranial magnetic stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","transcranial magnetic stimulation","Subjects will receive a series of 60 10s trains that will be presented over the course of the \\~3.5 min session. Each train will consist of 2 s of stimulation with an 8 s ITI. During the 2 s of stimulation, 10, 50 Hz bursts will be repeated at intervals of 200 ms (5 Hz). iTBS will be administered at 100% of the motor threshold (MT).",[9],[21],{"name":22,"affiliation":5,"role":23},"Nicholas Balderston, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","12157463058","nicholas.balderston@pennmedicine.upenn.edu",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-75.16362,39.95238,{"lat":41,"lon":40},[44],{"name":45,"role":26,"phone":46,"phoneExt":10,"email":28},"Nicholas l Balderston, PhD","215-746-3058",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100606830","menstrual-cycle-tms-plasticity-pilot-100606830",false,"NCT07180654","Menstrual Cycle TMS Plasticity Pilot","Pilot Study on Menstrual Cycle-Related Hormonal Effects on Motor Cortex Plasticity Assessed by TMS in Healthy Young Adults","Inclusion Criteria:\n\n* Able to give their consent\n* If female, must have menstrual cycles of normal frequency, regularity, and duration.\n\nExclusion Criteria:\n\n* Non-English speaking\n* Any medical condition that increases risk for TMS\n* History of seizure\n* History of epilepsy\n* Increased risk of seizure for any reason",true,"ALL","20 Years","40 Years",{"count":61,"type":62},100,"ESTIMATED","OBSERVATIONAL","Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females.\n\nAim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS response.\n\nAim 3: Examine associations between serum hormone levels and TMS-induced plasticity within and between sexes.",[66],"Cortical Activation",[17,68,69],"cortical excitability","hormones","2026-01-07",{"date":72,"type":73},"2026-01-09","ACTUAL",{"date":75,"type":73},"2025-12-15",{"date":77,"type":62},"2028-10-31",{"name":5,"class":6},1]