[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100475461":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":30,"centralContacts":35,"locations":46,"responsibleParty":66,"collaborators":10,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":10,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":10,"studyType":82,"phases":10,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Rady Pediatric Genomics & Systems Medicine Institute","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Enrollees",null,"These participants will be subject to whole genome sequencing to identify genetic changes and a EHR-Based network model to predict psychiatric outcomes in youth with IDDs.",[13,14],"Genetic: Genomic sequencing and molecular diagnostic results, if any.","Other: EHR-Based Network Model",{"label":16,"type":10,"description":17,"interventionNames":10},"Historical Control Group","A historical control group from public databases will be used to compare against enrollees.",[19,26],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"GENETIC","Genomic sequencing and molecular diagnostic results, if any.","Genomic sequencing results may be used for diagnosis and treatment of participants.",[9],[25],"Pediatric Precision Medicine",{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"EHR-Based Network Model","EHR-based network will be created to predict psychiatric outcomes in youth with IDDs",[9],[31],{"name":32,"affiliation":33,"role":34},"Aaron Besterman, MD, MD","Rady Children's Institute for Genomic Medicine","PRINCIPAL_INVESTIGATOR",[36,42],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Aaron Besterman, MD","CONTACT","858-576-1700","221633","abesterman@health.ucsd.edu",{"name":43,"role":38,"phone":39,"phoneExt":44,"email":45},"Corrine Blucher, BS","221632","cblucher@rchsd.org",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Rady Children's Hospital San Diego","RECRUITING","San Diego","California","92123","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-117.16472,32.71571,{"lat":59,"lon":58},[62,64],{"name":32,"role":38,"phone":63,"phoneExt":10,"email":41},"858-494-2429",{"name":43,"role":38,"phone":65,"phoneExt":44,"email":45},"8585761700",{"type":34,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Aaron Besterman","Psychiatrist, Clinical Investigator","100475461","mental-health-crises-in-youth-with-idds-100475461",false,"NCT05471232","Mental Health Crises in Youth With IDDs","Understanding Mental Health Crises in Youth With Intellectual and Developmental Disabilities","Inclusion Criteria:\n\nChild\u002Fadolescents admitted to the RCHSD ED with an IDD presenting in a MHC that includes, but is not limited to:\n\n* Aggression towards others\n* Severe agitation\n* Self-injury\n* Elopement\n\nOR\n\nBiological parents of child\u002Fadolescent enrolled in this study for the purposes of reflex testing. (Family members are eligible for participation in this study if they presumed genetically related to a participant).\n\nExclusion Criteria:\n\nChild\u002FAdolescents participants who do not meet any of the inclusion criteria, or those who:\n\n* Already received any prior whole genome sequencing or exome sequencing\n* Unable to approach the family or patient for enrollment\n* Unable to obtain informed consent\n* family members are ineligible for participation in this study if they are known to not be genetically related to the child\u002Fadolescent participant and\u002For if they are a member of a protected research population.","ALL","7 Years","17 Years",{"count":80,"type":81},150,"ESTIMATED","OBSERVATIONAL","This study is an unmatched, case-control study of 150 youth (Ages 7-17) with a parent reported Intellectual Developmental Disability (IDD) who present to Rady Children's Hospital Emergency Department with a Mental Health Crisis (MHC). Rady Children's Institute for Genomic Medicine (RCIGM) will collect biological samples (such as blood) of these participants to study their genomes, medical and psychiatric profiles to better understand specific characteristics that may predispose them to MHC's. The 150 youth will be compared to historical, publicly available cohorts of youth with IDD's",[85],"Intellectual Disability",[87,88,89,90,91],"Genomic","Intellectual and Developmental Disability","Mental Health Crisis","Pediatric","Rady Children's Hospital","2024-08-06",{"date":94,"type":95},"2024-08-09","ACTUAL",{"date":97,"type":95},"2023-03-29",{"date":99,"type":81},"2027-07-01",{"name":5,"class":6},1]