[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100508039":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":34,"responsibleParty":46,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":70,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Heinrich-Heine University, Duesseldorf","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"patients who received primary surgery",null,"preoperative CT scans available for assessing resectability criteria and presumed mesopancreatic infiltration status (CT scans are centrally evaluated) UICC 8th edition staging including CRM Tumor size in mm measured twice perpendicular Age Sex CA 19-9 values (preoperative) ECOG status BMI Type of PD (tail preserved vs total PD) simultaneous vessel resection (complete, partial; combined arterial and venous)",[13],"Procedure: oncological relevance of the mesopancreas",{"label":15,"type":10,"description":16,"interventionNames":17},"patients who received neoadjuvant treatment prior to surgery","Peri-therapeutic CT scans available for assessing resectability criteria and presumed mesopancreatic infiltration status (CT scans are centrally evaluated) UICC 8th edition staging including CRM Tumor size in mm measured twice perpendicular Age Sex CA 19-9 values (peri-therapeutic) ECOG status BMI Type of neoadjuvant Therapy Type of PD (tail preserved vs total PD), simultaneous vessel resection (complete, partial; combined arterial and venous) Tumor response according to CAP",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","oncological relevance of the mesopancreas","Invasion status Invasion depth in mm Depth of mesopancreas in mm Treitz fascia intact (histopathological examination)",[15,9],[25],{"name":26,"affiliation":27,"role":28},"Sami Alexander Safi, MD","Department of Surgery (A), University Hospital of Duesseldorf of the Heinrich Heine University Duesseldorf, Germany","PRINCIPAL_INVESTIGATOR",[30],{"name":26,"role":31,"phone":32,"phoneExt":10,"email":33},"CONTACT","+4916097937947","safi@hhu.de",[35],{"facility":36,"status":10,"city":37,"state":10,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":10},"University Hospital Duesseldorf, Heinrich Heine University","Düsseldorf","Germany","DE",{"type":41,"coordinates":42},"Point",[43,44],6.77927,51.22319,{"lat":44,"lon":43},{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100508039","mesopancreas-study-in-pancreatic-cancer-100508039",false,"NCT05895214","Mesopancreas Study in Pancreatic Cancer","MESOPANC-01 Study: The Mesopancreas and the Ductal Adenocarcinoma of the Pancreatic Head: From Preoperative Imaging to Histopathological and Surgical Outcome","MESOPANC-01","Inclusion Criteria:\n\n* All patients age ≥18 years who are admitted for primary surgery or patients who Received neoadjuvant therapy prior to surgery\n* CRM analysis through Pathologic Institute in study centre already implemented (see LEEPP protocol Menon et al (2009) Impact of margin status on survival following pancreatoduodenectomy for cancer: the Leeds Pathology Protocol (LEEPP). HPB 11(1):18-24)\n* Preoperative computed-tomographic Imaging (biphasic) prior to surgery (if resected without neoadjuvant treatment)\n* Pre-chemotherapeutic computed-tomographic and post-chemotherapeutic computed-tomographic if neoadjuvantly treated (biphasic).\n* indepth information of surgical procedure (pancreatic tail preserved:yes\u002Fno, pylorus preserved resection: yes\u002Fno, venous resection: complete\u002Fpartial\u002Fno, arterial resection: complete\u002Fpartial\u002Fno)\n\nExclusion Criteria:\n\n* Palliation\n* Abort of operative procedure\n* No preoperative computed-tomography for staging\n* No pathological CRM Implementation according to the LEEPP","ALL","18 Years",{"count":59,"type":60},500,"ESTIMATED","24 Months","OBSERVATIONAL","After the Introduction of the pathological circumferential resection margin (CRM status by LEEPP Protocol), residual cancer (R1 resection) was most often found in the dorsal and medial resection margins. Yet only the medial resection margin is preoperatively evaluated during staging, while the dorsal resection margin which embeds the mesopancreatic fat and thus resembles the area of the mesopancreas, is not considered during preoperative assessment for resectability. Local recurrence is similarly prevalent as systemic relapse, and revised lower rates of R0CRM- resections through the LEEPP protocol explained the poor local tumor control. The aim of this study is to interdisciplinary approach the circumferential infiltration status of the PDAC concentrating foremost on the mesopancreas of the dorsal resection margin by including anatomic and embryologic derived perspectives.",[65,66,67,68,69],"PDAC","Pancreatoduodenectomy","Margin, Resection","Surgery","Local Recurrent Tumor","NOT_YET_RECRUITING","2023-05-30",{"date":73,"type":74},"2023-06-08","ACTUAL",{"date":76,"type":60},"2023-06-01",{"date":78,"type":60},"2027-01-01",{"name":5,"class":6},1]