[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100345971":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":19,"responsibleParty":38,"collaborators":7,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":7,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":7,"studyType":54,"phases":7,"briefSummary":55,"conditions":56,"keywords":7,"overallStatus":22,"whyStopped":7,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},{"fullName":5,"class":6},"Rigshospitalet, Denmark","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Peter Schwarz, Prof, MD","PRINCIPAL_INVESTIGATOR",[13],{"name":14,"role":15,"phone":16,"phoneExt":17,"email":18},"Kristian Buch, cand.med.","CONTACT","29434376","+45","buch.kristian@gmail.com",[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Rigshospitalet","RECRUITING","Copenhagen","Danmark","2100","Denmark","DK",{"type":29,"coordinates":30},"Point",[31,32],12.56553,55.67594,{"lat":32,"lon":31},[35],{"name":36,"role":15,"phone":16,"phoneExt":7,"email":37},"Kristian Buch, MD","kristian.buch@regionh.dk",{"type":11,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Kristian Buch","Principal investigator","100345971","metabolic-and-bone-changes-after-adjuvant-cancer-treatments-in-early-non-metastatic-breast-cancer-100345971",false,"NCT03784651","Metabolic and Bone Changes After Adjuvant Cancer Treatments in Early Non-metastatic Breast Cancer","Metabolic and Bone Changes After Adjuvant Cancer Treatments in Early Non-metastatic Breast Cancer - a 5-year Follow-up Study.","Inclusion Criteria:\n\n* Postmenopausal\n* Breast cancer stage I-III\n* Eligible to receive (neo-)adjuvant chemotherapy\u002Fother antineoplastic treatment\n\nExclusion Criteria:\n\n* Prior malignancy\n* Metabolic disease (diabetes mellitus etc)","FEMALE","50 Years","70 Years",{"count":52,"type":53},120,"ESTIMATED","OBSERVATIONAL","Breast cancer is the most common cancer type in European women. Patients treated for early non-metastatic breast cancer comprise a growing group of survivors due to early diagnosis and improved treatment. Many of these survivors experience adverse effects such as decreased bone mineral density, derangement of metabolic markers (fat, glucose, insulin) and increased blood pressure. Increasing risk of bone fracture and cardiometabolic disease (eg. diabetes mellitus type 2).\n\nThe purpose of this study is to identify mechanisms behind cardiometabolic changes that may be connected to the (neo-)adjuvant treatment. On top of this we hope to indentify potential biological markers that can help prevent development of metabolic disease.\n\nWe will be recruiting 120 post-menopausal women age 50-70 with early breast cancer and 1-2 times a year for 5 years examine bone mineral density, body composition, glucose and fat metabolism and nerve damage. A questionnaire will be used to collect information on diet, physical activity and quality of life. Derudover anvendes spørgeskemaer til at indsamle information vedrørende. This new knowledge will help clinicians start adequate preventive measures to help patients avoid cardiometabolic disease secondary to cancer treatment.",[57,58,59,60,61],"Bone Fracture","Glucose, High Blood","Insulin Resistance","Blood Pressure, High","Cholesterolemia","2021-09-14",{"date":64,"type":65},"2021-09-16","ACTUAL",{"date":67,"type":65},"2018-12-17",{"date":69,"type":53},"2026-11",{"name":5,"class":6},1]