[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100457767":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":21,"locations":30,"responsibleParty":47,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Texas A&M University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Controls",null,"Study subjects that are eligible based on inclusion\u002Fexclusion criteria\n\nScreening visit: body weight and composition by DXA, height, and vital signs will be assessed.\n\nStudy day(s): may include combinations of stable tracer infusions and with blood draws, cognitive and muscle performance testing",[13],"Other: Stable tracer infusion in a postabsorptive state",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Stable tracer infusion in a postabsorptive state","Multiple stable-labeled tracers of amino acids, ketoacids, glycerol, short-chain fatty acids",[9],[20],"Stable tracer infusion",[22,27],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Laura Ruebush, PhD","CONTACT","979-422-1789","le.ruebush@ctral.org",{"name":28,"role":24,"phone":25,"phoneExt":10,"email":29},"Marielle Engelen, PhD","mpkj.engelen@ctral.org",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Human Clinical Research Building","RECRUITING","College Station","Texas","77845","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-96.33441,30.62798,{"lat":43,"lon":42},[46],{"name":23,"role":24,"phone":10,"phoneExt":10,"email":26},{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Marielle PKJ Engelen, PhD","Professor & Chancellor Edges Fellow","100457767","metabolic-and-functional-consequences-of-aging-in-health-and-disease-100457767",false,"NCT05240885","Metabolic and Functional Consequences of Aging in Health and Disease","Inclusion Criteria:\n\n* Stable body-weight (± 5%) for the past 3 months\n* Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations.\n* Ability to walk, sit down and stand up independently or with walking mobility aids\n* Ability to lie in a supine or elevated position for up to 3 hours\n* Willingness and ability to comply with the protocol\n\nExclusion Criteria:\n\n* Insulin dependent diabetes mellitus\n* Established diagnosis of malignancy\n* History of untreated metabolic diseases including hepatic or renal disorder\n* Presence of acute illness or metabolically unstable chronic illness\n* Presence of fever within the last 3 days\n* Use of short course of oral corticosteroids within 4 weeks preceding study day\n* Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements\n* (Possible) pregnancy\n* Already enrolled in another clinical trial and that clinical trial interferes with participating in this study",true,"ALL","50 Years",{"count":61,"type":62},100,"ESTIMATED","OBSERVATIONAL","Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. Current knowledge of the aging experience and the trajectories of physical and cognitive decline across various age groups are not well-understood, yet crucial to prevent spending added years in disease. Hence, the study objective is to develop the metabolic profile associated with aging-related disorders measured as the incidence of impaired functional capacity, cognitive function, and\u002For well-being.",[66],"Aging",[68,69,70],"stable isotopes","disease","metabolism","2025-09-26",{"date":73,"type":74},"2025-10-02","ACTUAL",{"date":76,"type":74},"2022-03-04",{"date":78,"type":62},"2026-09",{"name":5,"class":6},1]