[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615047":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":56,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Pontificia Universidad Catolica de Chile","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Linoleic Acid-Rich Oil","EXPERIMENTAL","Participants in this group will receive a daily supplement of a linoleic acid (LA)-rich oil at a dose of 0.4 mL per kilogram of body weight per day for 8 weeks.",[13],"Dietary Supplement: Linoleic Acid-Rich Oil",{"label":15,"type":16,"description":17,"interventionNames":18},"Blend Oil","ACTIVE_COMPARATOR","Participants in this group will receive a daily supplement of a blend oil at 0.4 mL per kilogram of body weight per day for 8 weeks.",[19],"Dietary Supplement: Blend Oil",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Participants in the experimental group will receive a daily supplement of a linoleic acid (LA)-rich oil at a dose of 0.4 mL per kilogram of body weight per day, taken orally for 8 weeks. The oil is characterized by a high content of omega-6 polyunsaturated fatty acids, primarily linoleic acid (\\~60%).\n\nTo facilitate adherence and appropriate use, participants will receive a recipe booklet encouraging the use of the oil in cold or minimally cooked preparations, or as a topping over foods. They will be instructed to avoid prolonged heating and to store the oil protected from light and at room temperature.\n\nThe supplement will be provided in identical coded bottles to maintain single-blind conditions. Participants will be asked to maintain their usual diet and lifestyle throughout the intervention.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Participants in the control group will receive a daily supplement of a blend oil at a dose of 0.4 mL per kilogram of body weight per day, taken orally for 8 weeks. The blend was formulated to contain approximately equal proportions of saturated, monounsaturated, and polyunsaturated fatty acids, with less than half the linoleic acid content of the LA-rich oil.\n\nParticipants will receive a recipe booklet promoting the use of the oil in cold dishes or lightly cooked preparations, or as a dressing or drizzle over meals. They will also be instructed on proper storage away from heat and direct light.\n\nThe supplement will be supplied in identical coded bottles to ensure blinding. Participants will maintain their usual diet and lifestyle during the intervention.",[15],[30],{"name":31,"affiliation":5,"role":32},"Loni Berkowitz, PhD","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","23543862","+56","lberkowi@uc.cl",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Centro de Investigaciones Clínicas UC (CICUC) - Pontificia Universidad Católica de Chile","RECRUITING","Santiago","Santiago Metropolitan","8330024","Chile","CL",{"type":49,"coordinates":50},"Point",[51,52],-70.64827,-33.45694,{"lat":52,"lon":51},[55],{"name":31,"role":35,"phone":25,"phoneExt":25,"email":38},{"type":32,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Loni Berkowitz Fiebich","Assistant Professor","100615047","metabolic-effects-of-linoleic-acid-rich-oil-compared-to-a-blend-oil-in-adults-with-insulin-resistance-100615047",false,"NCT07287514","Metabolic Effects of Linoleic Acid-Rich Oil Compared to a Blend Oil in Adults With Insulin Resistance","Role of Linoleic Acid in Cardiometabolic Health Beyond Its Lipid-lowering Effects, and Its Dietary and Pathophysiological Implications","Inclusion Criteria:\n\n* Men and women aged 20 to 60 years.\n* Insulin resistance (HOMA-IR \\> 2.6).\n* At least one cardiometabolic risk factor: abdominal obesity (waist circumference \\> 90 cm in men or \\> 80 cm in women); low HDL-cholesterol (\\\u003C 40 mg\u002FdL in men or \\\u003C 50 mg\u002FdL in women); elevated LDL-cholesterol (\\> 70 \u002F 100 \u002F 130 mg\u002FdL, according to estimated cardiovascular risk); or elevated blood pressure (≥ 130\u002F85 mmHg).\n\nExclusion Criteria:\n\n* Diabetes diagnosis.\n* Severe psychiatric illness.\n* Malabsorption disorders or previous bariatric surgery.\n* Pregnancy or lactation.\n* Previous clinical cardiovascular disease.\n* Regular use of medications that could influence study outcomes, including:\n\nlipid-lowering agents insulin sensitizers antihypertensive drugs anticoagulants antiretroviral therapy thyroid hormones oral corticosteroids immunosuppressants polyunsaturated fatty acid (PUFA) supplements.\n\n* Fasting serum triglycerides ≥ 500 mg\u002FdL or LDL-cholesterol ≥ 190 mg\u002FdL.\n* Body mass index (BMI) ≥ 35 kg\u002Fm².\n* Very high blood pressure.\n* Any additional condition that may limit adherence to the study.","ALL","20 Years","60 Years",{"count":70,"type":71},120,"ESTIMATED","INTERVENTIONAL",[74],"NA","Linoleic acid (LA), the predominant omega-6 polyunsaturated fatty acid in human diets, has been associated with improved lipid metabolism and insulin sensitivity compared with saturated fats. However, its role in metabolic health remains debated due to the limited number of well-controlled intervention studies.\n\nThis randomized controlled trial aims to evaluate the metabolic effects of an LA-rich oil compared with a blended oil in adults with insulin resistance. Participants will be randomly assigned to receive either a daily supplement of LA-rich oil or a control blend oil for 8 weeks, while maintaining their usual diet and lifestyle. The primary outcome is the change in insulin resistance, assessed by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). Secondary outcomes include changes in fasting glucose, insulin, lipid profile, inflammatory and oxidative stress markers, and body composition.\n\nThe study is designed as a single-blind, parallel-group intervention conducted at the Pontifical Catholic University of Chile. The results are expected to clarify the effects of increased dietary linoleic acid intake on insulin sensitivity and metabolic risk factors, contributing to the ongoing debate about the role of omega-6 fatty acids in cardiometabolic health.",[77,78],"Insulin Resistance","Metabolic Disease",[80,77,81],"linoleic acid","omega-6 fatty acid","2025-12-03",{"date":84,"type":85},"2025-12-17","ACTUAL",{"date":87,"type":85},"2025-05-13",{"date":89,"type":71},"2026-12",{"name":5,"class":6},1]