[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584076":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":21,"responsibleParty":300,"collaborators":303,"id":363,"slug":364,"hasResults":365,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":369,"eligibilityCriteria":370,"healthyVolunteers":365,"sex":371,"minAge":372,"maxAge":10,"enrollmentInfo":373,"targetDuration":376,"studyType":377,"phases":10,"briefSummary":378,"conditions":379,"keywords":381,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":396},{"fullName":5,"class":6},"Centro Cardiologico Monzino","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Heart failure patients",null,"Patients with systolic heart failure, able to exercise",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Piergiuseppe Agostoni, Professor","CONTACT","+390258002010","piergiuseppe.agostoni@ccfm.it",{"name":19,"role":15,"phone":16,"phoneExt":10,"email":20},"Elisabetta Salvioni, PhD","elisabetta.salvioni@ccfm.it",[22,37,50,63,76,89,98,110,119,128,137,146,155,167,176,185,193,205,217,229,238,246,255,267,279,288],{"facility":5,"status":23,"city":24,"state":25,"zip":26,"country":25,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"RECRUITING","Milan","Italy","20138","IT",{"type":29,"coordinates":30},"Point",[31,32],12.59836,42.78235,{"lat":32,"lon":31},[35],{"name":36,"role":15,"phone":16,"phoneExt":10,"email":20},"Piergiuseppe Agostoni",{"facility":38,"status":23,"city":39,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":40,"geoPoint":44,"contacts":45},"Ospedali Riuniti di Ancona","Ancona",{"type":29,"coordinates":41},[42,43],13.5103,43.60717,{"lat":43,"lon":42},[46],{"name":47,"role":15,"phone":48,"phoneExt":10,"email":49},"Maria Vittoria Matassini","000","mavimatassini@gmail.com",{"facility":51,"status":23,"city":52,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Istituti Clinici Scientifici Maugeri Bari","Bari",{"type":29,"coordinates":54},[55,56],16.86982,41.12066,{"lat":56,"lon":55},[59],{"name":60,"role":15,"phone":61,"phoneExt":10,"email":62},"Andrea Passantino","00000","andrea.passantino@icsmaugeri.it",{"facility":64,"status":23,"city":65,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Ospedale papa Giovanni XXIII","Bergamo",{"type":29,"coordinates":67},[68,69],9.66721,45.69601,{"lat":69,"lon":68},[72],{"name":73,"role":15,"phone":74,"phoneExt":10,"email":75},"Annamaria Iorio","0000","anita.iorio@hotmail.it",{"facility":77,"status":78,"city":79,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Spedali Civili Brescia","NOT_YET_RECRUITING","Brescia",{"type":29,"coordinates":81},[82,83],10.21472,45.53558,{"lat":83,"lon":82},[86],{"name":87,"role":15,"phone":74,"phoneExt":10,"email":88},"Savina Nodari","studi.clinici@asst-spedalicivili.it",{"facility":90,"status":23,"city":79,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":91,"geoPoint":93,"contacts":94},"Spedali Civili",{"type":29,"coordinates":92},[82,83],{"lat":83,"lon":82},[95],{"name":96,"role":15,"phone":97,"phoneExt":10,"email":88},"Marco Metra","000000",{"facility":99,"status":23,"city":100,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Università di Foggia","Foggia",{"type":29,"coordinates":102},[103,104],15.55188,41.45845,{"lat":104,"lon":103},[107],{"name":108,"role":15,"phone":97,"phoneExt":10,"email":109},"Michele Correale","michele.correale@libero.it",{"facility":111,"status":23,"city":24,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":112,"geoPoint":114,"contacts":115},"I.R.C.C.S. Ospedale San Raffaele",{"type":29,"coordinates":113},[31,32],{"lat":32,"lon":31},[116],{"name":117,"role":15,"phone":61,"phoneExt":10,"email":118},"Rosa Raimondo","RAIMONDO.ROSA@hsr.it",{"facility":120,"status":23,"city":24,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":121,"geoPoint":123,"contacts":124},"IRCCS Istituto Auxologico Italiano",{"type":29,"coordinates":122},[31,32],{"lat":32,"lon":31},[125],{"name":126,"role":15,"phone":61,"phoneExt":10,"email":127},"Gianfranco Parati","trials@auxologico.it",{"facility":129,"status":23,"city":24,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":130,"geoPoint":132,"contacts":133},"IRCCS Multimedica- Ospedale San Giuseppe",{"type":29,"coordinates":131},[31,32],{"lat":32,"lon":31},[134],{"name":135,"role":15,"phone":61,"phoneExt":10,"email":136},"Gaia Cattadori","gaia.cattadori@multimedica.it",{"facility":138,"status":78,"city":24,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":139,"geoPoint":141,"contacts":142},"Istituti Clinici Scientifici Maugeri Milano",{"type":29,"coordinates":140},[31,32],{"lat":32,"lon":31},[143],{"name":144,"role":15,"phone":48,"phoneExt":10,"email":145},"Maurizio Bussotti","maurizio.bussotti@icsmaugeri.it",{"facility":147,"status":78,"city":24,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":148,"geoPoint":150,"contacts":151},"Ospedale Cà Granda- A.O. Niguarda",{"type":29,"coordinates":149},[31,32],{"lat":32,"lon":31},[152],{"name":153,"role":15,"phone":61,"phoneExt":10,"email":154},"Enrico Perna","enrico.perna@ospedaleniguarda.it",{"facility":156,"status":23,"city":157,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":158,"geoPoint":162,"contacts":163},"Azienda Ospedaliera dei Colli - Ospedale Monaldi","Naples",{"type":29,"coordinates":159},[160,161],14.26811,40.85216,{"lat":161,"lon":160},[164],{"name":165,"role":15,"phone":97,"phoneExt":10,"email":166},"Giuseppe Limongelli","limongelligiuseppe@libero.it",{"facility":168,"status":23,"city":157,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":169,"geoPoint":171,"contacts":172},"Federico II hospital",{"type":29,"coordinates":170},[160,161],{"lat":161,"lon":160},[173],{"name":174,"role":15,"phone":74,"phoneExt":10,"email":175},"Antonio Cittadini","antonio.cittadini@unina.it",{"facility":177,"status":23,"city":157,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":178,"geoPoint":180,"contacts":181},"Università degli Studi di Napoli Federico II",{"type":29,"coordinates":179},[160,161],{"lat":161,"lon":160},[182],{"name":183,"role":15,"phone":74,"phoneExt":10,"email":184},"Pasquale Perrone Filardi","paolilloste@gmail.com",{"facility":186,"status":78,"city":187,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":188,"geoPoint":192,"contacts":10},"Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione","Palermo",{"type":29,"coordinates":189},[190,191],13.3636,38.1166,{"lat":191,"lon":190},{"facility":194,"status":23,"city":195,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"Ospedale Guglielmo da Saliceto","Piacenza",{"type":29,"coordinates":197},[198,199],9.69342,45.05242,{"lat":199,"lon":198},[202],{"name":203,"role":15,"phone":61,"phoneExt":10,"email":204},"Francesco Di Spigno","F.DiSpigno@ausl.pc.it",{"facility":206,"status":23,"city":207,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":208,"geoPoint":212,"contacts":213},"Fondazione Gabriele Monasterio","Pisa",{"type":29,"coordinates":209},[210,211],10.4036,43.70853,{"lat":211,"lon":210},[214],{"name":215,"role":15,"phone":74,"phoneExt":10,"email":216},"Michele Emdin","emdin@ftgm.it",{"facility":218,"status":23,"city":219,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":220,"geoPoint":224,"contacts":225},"Azienda Ospedaliera San Camillo-Forlanini","Roma",{"type":29,"coordinates":221},[222,223],11.10642,44.99364,{"lat":223,"lon":222},[226],{"name":227,"role":15,"phone":74,"phoneExt":10,"email":228},"Federica Re","federica.re@sancamilloforlanini.rm.it",{"facility":230,"status":23,"city":219,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":231,"geoPoint":233,"contacts":234},"Azienda Ospedaliera Sant'Andrea",{"type":29,"coordinates":232},[222,223],{"lat":223,"lon":222},[235],{"name":236,"role":15,"phone":74,"phoneExt":10,"email":237},"Damiano Magrì","damiano.magri@uniroma1.it",{"facility":239,"status":78,"city":240,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":241,"geoPoint":245,"contacts":10},"Azienda Ospedaliero-Universitaria Policinico Umberto I","Rome",{"type":29,"coordinates":242},[243,244],12.51133,41.89193,{"lat":244,"lon":243},{"facility":247,"status":23,"city":240,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":248,"geoPoint":250,"contacts":251},"Santo Spirito Hospital",{"type":29,"coordinates":249},[243,244],{"lat":244,"lon":243},[252],{"name":253,"role":15,"phone":61,"phoneExt":10,"email":254},"Angela B Scardovi","angela.scardovi@aslroma1.it",{"facility":256,"status":23,"city":257,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":258,"geoPoint":262,"contacts":263},"IRCCS Policlinico San Donato","San Donato Milanese",{"type":29,"coordinates":259},[260,261],9.26838,45.41047,{"lat":261,"lon":260},[264],{"name":265,"role":15,"phone":74,"phoneExt":10,"email":266},"Massimo Piepoli","massimo.piepoli@unimi.it",{"facility":268,"status":78,"city":269,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":270,"geoPoint":274,"contacts":275},"S. Maria alle Scotte Hospital UOC cardiologia clinico-chirurgica (UTIC)","Siena",{"type":29,"coordinates":271},[272,273],11.33064,43.31822,{"lat":273,"lon":272},[276],{"name":277,"role":15,"phone":61,"phoneExt":10,"email":278},"Francesca Righini","righini.francescamaria@gmail.com",{"facility":280,"status":78,"city":269,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":281,"geoPoint":283,"contacts":284},"S. Maria alle Scotte Hospital UOSA malattie cardiovascolari",{"type":29,"coordinates":282},[272,273],{"lat":273,"lon":272},[285],{"name":286,"role":15,"phone":48,"phoneExt":10,"email":287},"Alberto Palazzuoli","palazzuoli2@unisi.it",{"facility":289,"status":23,"city":290,"state":10,"zip":10,"country":25,"countryCode":27,"cosmosGeoPoint":291,"geoPoint":295,"contacts":296},"Azienda sanitaria universitaria Giuliano Isontina (ASUGI)","Trieste",{"type":29,"coordinates":292},[293,294],13.77678,45.64953,{"lat":294,"lon":293},[297],{"name":298,"role":15,"phone":74,"phoneExt":10,"email":299},"Gianfranco SInagra","gianfranco.sinagra@asugi.sanita.fvg.it",{"type":301,"investigatorFullName":36,"investigatorTitle":302,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Professor",[304,306,308,311,313,315,317,319,321,323,325,327,329,331,333,335,337,339,341,343,345,347,349,351,353,355,357,359,361],{"name":305,"class":6},"Santo Spirito Hospital, Italy",{"name":307,"class":6},"Fondazione Toscana Gabriele Monasterio",{"name":309,"class":310},"Spedali Civili, University of Brescia, Italy","UNKNOWN",{"name":312,"class":6},"Monaldi Hospital",{"name":314,"class":310},"Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)",{"name":316,"class":6},"San Raffaele University Hospital, Italy",{"name":318,"class":6},"University of Foggia",{"name":320,"class":6},"Azienda Ospedaliera Niguarda Cà Granda",{"name":322,"class":6},"Azienda Policlinico Umberto I",{"name":324,"class":310},"Federico II University of Naples, Department of Clinical Medicine and Surgery, Naples, Italy",{"name":326,"class":310},"Città di Lecce Hospital",{"name":328,"class":310},"Policlinico G . Martino, Messina Italy",{"name":330,"class":6},"Azienda Ospedaliera Universitaria Senese",{"name":332,"class":6},"Azienda Sanitaria di Firenze",{"name":334,"class":310},"Ospedale San Luca, Istituto Auxologico Italiano, Milano",{"name":336,"class":310},"Casa di Cura Mater Dei",{"name":338,"class":6},"University of Bari",{"name":340,"class":6},"Azienda Ospedaliera di Perugia",{"name":342,"class":310},"I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Italy",{"name":344,"class":6},"IRCCS Multimedica",{"name":346,"class":6},"Ospedali Riuniti Ancona",{"name":348,"class":6},"A.O. Ospedale Papa Giovanni XXIII",{"name":350,"class":6},"S. Andrea Hospital",{"name":352,"class":6},"Istituti Clinici Scientifici Maugeri SpA",{"name":354,"class":310},"Istituto Auxologico Italiano - IRCCS - Ospedale San Luca - Milano",{"name":356,"class":310},"Azienda Ospedaliero-Universitaria Senese",{"name":358,"class":6},"The Mediterranean Institute for Transplantation and Advanced Specialized Therapies",{"name":360,"class":6},"Federico II University",{"name":362,"class":310},"Ospedale Guglielmo da Saliceto, Piacenza","100584076","metabolic-exercise-test-data-combined-with-cardiac-and-kidney-indexes-mecki-score-evolution-identification-of-cardiovascular-risk-in-patients-with-heart-failure-100584076",false,"NCT06884631","Metabolic Exercise Test Data Combined with Cardiac and Kidney Indexes (MECKI) Score Evolution: Identification of Cardiovascular Risk in Patients with Heart Failure","Metabolic Exercise Test Data Combined with Cardiac and Kidney Indexes (MECKI) Score Evolution: Study of Cardiovascular Risk in Patients with Heart Failure","MECKI","Inclusion Criteria:\n\n* age \\>18 past or present heart failure (NYHA functional class I-III, stage C of the ACC\u002FAHA classification)\n* documentation of left ventricular systolic dysfunction (LVEF \\\u003C40%)\n* stable clinical conditions\n* previous or concomitant cardiopulmonary exercise test\n\nExclusion Criteria:\n\n* scheduled cardiovascular treatment\n* clinical unstable condition\n* History of pulmonary embolism, significant valvular disease, pericardial disease, severe COPD, exercise-induced angina, exercise-induced ECG changes, severe brady- or tachyarrhythmias, or the presence of comorbidities that interfere with exercise performance.","ALL","18 Years",{"count":374,"type":375},10000,"ESTIMATED","10 Years","OBSERVATIONAL","Heart failure is a complex condition involving multiple organs beyond the cardiovascular system, all influencing disease progression and prognosis. Accurate risk assessment requires considering multiple variables, as no single parameter alone provides a complete prognostic picture.\n\nThis has led to the development of prognostic models combining clinical and laboratory parameters. Some of these models incorporate cardiopulmonary exercise testing (CPET), which provides key prognostic indicators. Since the 1990s, CPET has been recommended in heart failure management guidelines due to its strong prognostic value when combined with clinical data.\n\nHowever, existing risk models often exclude important predictors such as ventilatory parameters from CPET (VE\u002FVCO₂), renal function, and hemoglobin levels. To address this gap, in 2012 the investigators developed the MECKI (Metabolic Exercise test data combined with Cardiac and Kidney Indexes) score, integrating oxygen consumption, ventilatory efficiency, and easily accessible biochemical and echocardiographic parameters. Unlike previous models requiring extensive data collection, MECKI is based on only six variables, making it practical and effective.\n\nRecent studies suggest the need to update the cutoff values and parameters used for risk stratification, as new therapies and treatment strategies may significantly alter prognostic accuracy in different patient populations.\n\nThis study aims to expand and refine the MECKI score by updating the patient dataset, optimizing its performance in specific subgroups, and aligning it with emerging therapeutic approaches.\n\nAdditionally, the investigators will evaluate whether the model's risk accuracy varies in advanced-stage patients, those with comorbidities, or under different treatment regimens. This could lead to correction factors that enhance the score's predictive power across diverse clinical scenarios, further improving its applicability and reliability in heart failure management.",[380],"Heart Failure",[382,383,384,385,386],"prognosis","risk score","heart failure","cardiopulmonary exercise test","exercise","2025-03-18",{"date":389,"type":390},"2025-03-19","ACTUAL",{"date":392,"type":390},"2021-02-10",{"date":394,"type":375},"2028-12-31",{"name":5,"class":6},26]