[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100496410":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":56,"collaborators":58,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":25,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":25,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Yale University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IR participants with standardized dinner","EXPERIMENTAL","Participants with global IR and tissue-specific IR. Participants with global IR (in both skeletal muscle and adipose tissue) and tissue-specific IR (in adipose tissue). Glucose tolerance, skeletal muscle\u002Fwhole-body insulin sensitivity and adipose tissue insulin sensitivity will be evaluated prior to intervention.\n\nContribution of DNL to hepatic VLDL will be measured using a deuterated water drink, to be ingested prior to the standardized dinner. Blood will be drawn the following morning for the measurement of deuterium incorporation into triglycerides. Plasma deuterium will be allowed to wash out over several weeks, and the 2nd deuterated water study will be performed.",[13],"Behavioral: Standardized Dinner",{"label":15,"type":10,"description":16,"interventionNames":17},"IR participants with standardized dinner and premeal exercise","Participants with global IR and tissue-specific IR. Participants with global IR (in both skeletal muscle and adipose tissue) and tissue-specific IR (in adipose tissue). Glucose tolerance, skeletal muscle\u002Fwhole-body insulin sensitivity and adipose tissue insulin sensitivity will be evaluated prior to intervention.\n\nDNL will be assessed in all participants after a single day with short bouts of premeal exercise with a standardized dinner.\n\nContribution of DNL to hepatic VLDL will be measured using a deuterated water drink, to be ingested prior to the standardized dinner. Blood will be drawn the following morning for the measurement of deuterium incorporation into triglycerides. Plasma deuterium will be allowed to wash out over several weeks, and the 2nd deuterated water study will be performed.",[13,18],"Behavioral: Premeal exercise",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Standardized Dinner","De novo lipogenesis (DNL) will be assessed in all participants with a standardized dinner",[9,15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Premeal exercise","DNL will be assessed in all participants with short bouts of premeal exercise with a standardized dinner",[15],[31],{"name":32,"affiliation":5,"role":33},"Daniel F Vatner, MD, PhD","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","203 785 5934","daniel.vatner@yale.edu",[40],{"facility":41,"status":42,"city":43,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"AMC Amsterdam","RECRUITING","Amsterdam","Netherlands","NL",{"type":47,"coordinates":48},"Point",[49,50],4.88969,52.37403,{"lat":50,"lon":49},[53],{"name":54,"role":36,"phone":25,"phoneExt":25,"email":55},"Kasper ter Horst, MD, PhD","k.w.terhorst@amsterdamumc.nl",{"type":57,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[59,61],{"name":60,"class":6},"Amsterdam UMC",{"name":62,"class":63},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100496410","metabolic-heterogeneity-underlying-hypertriglyceridemia-hepatic-triglyceride-biosynthesis-in-humans-with-different-insulin-resistance-phenotypes-100496410",false,"NCT05743868","Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes","Inclusion Criteria:\n\n* Ability to give informed consent\n* Overweight, defined as BMI 25-30 kg\u002Fm2\n* Modest hypertriglyceridemia, defined as fasting plasma triglycerides 1.5-3.0mM\n* High risk of insulin resistance, defined as fasting plasma insulin \\>64pM\n* Stable weight for at least 3mo prior to participation\n\nExclusion Criteria:\n\n* Active or chronic liver disease, kidney disease, congestive heart failure, unstable angina, history of acute cardiovascular events within 6mo of screening, history of seizures or syncope, or an active infection requiring antimicrobial therapy;\n* Use of insulin, thiazolidinediones, SGLT2 inhibitors, or sulfonylureas;\n* Use of fibrates, omega 3 (fish oil), niacin, or PCSK9 antagonists;\n* Use of systemic glucocorticoids within 60d prior to participation;\n* Hematocrit \\\u003C35%;\n* Pregnancy of breastfeeding;\n* Active tobacco use, excessive alcohol intake (\\>14U\u002Fwk), or history of drug abuse.","ALL","18 Years","65 Years",{"count":74,"type":75},40,"ESTIMATED","INTERVENTIONAL",[78],"NA","The focus of this cross-sectional study is to determine the effects of tissue-specific (adipose tissue or muscle) vs global (combined) insulin resistance (IR) on hepatic triglyceride biosynthesis in humans, and to determine differential effects of an acute exercise intervention on hepatic triglyceride biosynthesis in these groups.",[81,82],"Insulin Resistance","Hypertriglyceridemia","2026-01-23",{"date":85,"type":86},"2026-01-27","ACTUAL",{"date":88,"type":86},"2023-11-16",{"date":90,"type":75},"2026-06",{"name":5,"class":6},1]