[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100387094":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":40,"responsibleParty":57,"collaborators":59,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"East Carolina University","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Low oxidizers\u002Fhigh lactate",null,"Individuals with low aerobic oxidation",{"label":13,"type":10,"description":14,"interventionNames":10},"High oxidizers\u002Flow lactate","Individuals with high aerobic oxidation",{"label":16,"type":10,"description":17,"interventionNames":18},"Obese","Severely obese scheduled for surgery",[19],"Procedure: Weight loss surgery",[21],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"PROCEDURE","Weight loss surgery","Severely obese women (BMI \\>40) undergo sleeve gastrectomy",[16],[27],{"name":28,"affiliation":5,"role":29},"Joseph Houmard, PhD","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Terry Jones, PhD","CONTACT","2527446249","joneste@ecu.edu",{"name":37,"role":33,"phone":38,"phoneExt":10,"email":39},"Nicholas Broskey, PhD","2527374684","broskeyn19@ecu.edu",[41],{"facility":5,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Greenville","North Carolina","27834","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-77.36635,35.61266,{"lat":52,"lon":51},[55,56],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},{"name":37,"role":33,"phone":38,"phoneExt":10,"email":39},{"type":58,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[60,62],{"name":61,"class":6},"Duke University",{"name":63,"class":6},"University of Arkansas","100387094","metabolic-inflexibility-is-related-to-elevated-muscle-anaerobic-glycolysis-100387094",false,"NCT04320264","Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis","Inclusion Criteria:\n\n* 18-50 years old\n* BMI of 25 - 30 kg\u002Fm2\n* BMI \\> 40kg\u002Fm2\n* Lactate levels in top and lower 25%\n\nExclusion Criteria:\n\n* Pregnant women\n* Mentally disabled\n* Prisoners\n* Smokers\n* Subjects with heart disease\n* Type 1 and 2 diabetes\n* Endocrine disease\n* Hypertension\n* Musculoskeletal disease\n* Peripheral occlusion\n* Hepatic disease\n* Have had weight fluctuations exceeding + 3% in the previous 12 months\n* On medications which alter carbohydrate metabolism will not be studied","ALL","18 Years","50 Years",{"count":74,"type":75},100,"ESTIMATED","OBSERVATIONAL","The focus of this proposal is on overweight (25\\>BMI\\\u003C30 kg\u002Fm2) subjects, as these individuals exhibit a high risk of becoming obese and\u002For developing metabolic diseases. We hypothesize that in some overweight individuals there is a \"metabolic program\" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.",[79],"Metabolic Inflexibility",[79,81,82],"Obesity","Anaerobic glycolysis","2025-08-04",{"date":85,"type":86},"2025-08-07","ACTUAL",{"date":88,"type":86},"2020-03-03",{"date":90,"type":75},"2025-12",{"name":5,"class":6},1]