[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100458222":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":52,"collaborators":55,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":10,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":10,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Imelda Hospital, Bonheiden","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Osteoporotic hip fracture patients",null,[12],"Other: Blood and bone marrow cell collection",{"label":14,"type":10,"description":10,"interventionNames":15},"Hip osteoarthritis patients",[12],[17],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"Blood and bone marrow cell collection","Collection of blood and bone marrow",[14,9],[22],{"name":23,"affiliation":24,"role":25},"Nick Van Gastel, PhD","de Duve Institute","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Michaël R. Laurent, MD PhD","CONTACT","+32485143267","michael.laurent@imelda.be",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Imelda Hospital","RECRUITING","Bonheiden","België","2820","Belgium","BE",{"type":42,"coordinates":43},"Point",[44,45],4.54714,51.02261,{"lat":45,"lon":44},[48,49],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},{"name":50,"role":51,"phone":10,"phoneExt":10,"email":10},"Hans Casteur, MD","SUB_INVESTIGATOR",{"type":25,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Michaël R Laurent, MD PhD","Principal Investigator",[56],{"name":57,"class":6},"Université Catholique de Louvain","100458222","metabolic-profiling-of-hematopoietic-stem-cells-in-clonal-hematopoiesis-chip-100458222",false,"NCT05246813","Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)","Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP): a Prospective Observational Study","Inclusion Criteria:\n\n* Age 65 years and older\n\nExclusion Criteria:\n\n* known haematological condition (myelodysplasia, leukemia, cancer)\n* inability to provide written informed consent","ALL","55 Years",{"count":68,"type":69},24,"ESTIMATED","OBSERVATIONAL","Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.",[73,74,75,76,77],"Osteoporosis","Osteoarthritis, Hip","Hip Fractures","Clonal Hematopoiesis of Indeterminate Potential","Aging","2026-03-24",{"date":80,"type":81},"2026-03-25","ACTUAL",{"date":83,"type":81},"2022-02-11",{"date":85,"type":69},"2030-12-31",{"name":5,"class":6},1]