[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100347976":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":21,"locations":29,"responsibleParty":73,"collaborators":76,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":10,"enrollmentInfo":93,"targetDuration":10,"studyType":96,"phases":10,"briefSummary":97,"conditions":98,"keywords":106,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Technical University of Munich","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Intensive Care Patients",null,"Postoperative high-risk patients who have been admitted to intensive care after surgery",{"label":13,"type":10,"description":14,"interventionNames":10},"Operative Control patients","Elective operative patients where control blood samples and muscle ultrasound will be measured.",[16,19],{"name":17,"affiliation":5,"role":18},"Stefan J Schaller, MD","PRINCIPAL_INVESTIGATOR",{"name":20,"affiliation":5,"role":18},"Hennig Wackerhage, PhD",[22,26],{"name":17,"role":23,"phone":24,"phoneExt":10,"email":25},"CONTACT","+4314040041020","stefan.schaller@meduniwien.ac.at",{"name":27,"role":23,"phone":24,"phoneExt":10,"email":28},"Marian Demitsch","aai-research@muv.ac.at",[30,50,63],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Medical University of Vienna","RECRUITING","Vienna","State of Vienna","1090","Austria","AT",{"type":39,"coordinates":40},"Point",[41,42],16.37208,48.20849,{"lat":42,"lon":41},[45,46,49],{"name":17,"role":23,"phone":24,"phoneExt":10,"email":25},{"name":47,"role":23,"phone":24,"phoneExt":10,"email":48},"Stefan Study Coordinator","aai-research@meduniwien.ac.at",{"name":17,"role":18,"phone":10,"phoneExt":10,"email":10},{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":62,"contacts":10},"Klinikum rechts der Isar, School of Medicine, Technical University of Munich","ACTIVE_NOT_RECRUITING","Munich","Bavaria","81675","Germany","DE",{"type":39,"coordinates":59},[60,61],11.57549,48.13743,{"lat":61,"lon":60},{"facility":64,"status":52,"city":65,"state":66,"zip":67,"country":56,"countryCode":57,"cosmosGeoPoint":68,"geoPoint":72,"contacts":10},"Charité - Universitätsmedizin Berlin","Berlin","State of Berlin","10117",{"type":39,"coordinates":69},[70,71],13.41053,52.52437,{"lat":71,"lon":70},{"type":18,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":31,"oldNameTitle":10,"oldOrganization":10},"Prof. Dr. Stefan Schaller, MD","Principal Investigator",[77,80,82],{"name":78,"class":79},"Helmholtz Zentrum München","INDUSTRY",{"name":81,"class":6},"Charite University, Berlin, Germany",{"name":31,"class":6},"100347976","metabolomics-study-on-postoperative-intensive-care-acquired-muscle-weakness-100347976",false,"NCT03810768","Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness","Metabolomics Pilot Study on Postoperative Intensive Care Acquired Muscle Weakness (MIRACLE-I Study)","MIRACLE I","Inclusion Criteria:\n\n* invasive mechanically ventilated critically ill patient with expected intensive care unit stay \\> 3 days\n* postoperative patient\n* ≥ 18 years old\n* American Society of Anesthesiology (ASA) classification ≥ III\n\nExclusion Criteria:\n\n* moribund patient\n* non-curative care (comfort care)","ALL","18 Years",{"count":94,"type":95},20,"ESTIMATED","OBSERVATIONAL","In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.\n\nAim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.",[99,100,101,102,103,104,105],"Metabolomics","Critical Care","Critical Illness","Critical Illness Myopathy","Critical Illness Polyneuropathy","Intensive Care (ICU) Myopathy","Muscle Weakness",[107,108,109],"pilot trial","muscle biopsy","blood metabolome","2026-02-28",{"date":112,"type":113},"2026-03-03","ACTUAL",{"date":115,"type":113},"2022-09-02",{"date":117,"type":95},"2026-12-31",{"name":5,"class":6},3]