[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590766":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":47,"collaborators":51,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":25,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":25,"overallStatus":76,"whyStopped":25,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Metacognitive therapy (MCT)","EXPERIMENTAL","Transdiagnostic MCT, focused on modifying dysfunctional metacognitions and thereby reducing attentional and cognitive processes central to maintaining anxiety disorders.",[13],"Behavioral: Metacognitive therapy (MCT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Unified protocol (UP)","ACTIVE_COMPARATOR","Transdiagnostic cognitive-behavioral therapy, focused on emotion regulation processes central to the development and maintenance of anxiety disorders, particularly neuroticism.",[19],"Behavioral: Unified protocol (UP)",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","MCT is delivered in weekly face-to-face sessions",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"UP is delivered in weekly face-to-face sessions",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Fredrik A Santoft, PhD","CONTACT","+46707275474","fredrik.santoft@ki.se",[36],{"facility":37,"status":25,"city":38,"state":25,"zip":25,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":25},"Psykiatri Nordväst and Psykiatri Sydväst, Region Stockholm","Stockholm","Sweden","SE",{"type":42,"coordinates":43},"Point",[44,45],18.06871,59.32938,{"lat":45,"lon":44},{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Fredrik Santoft","Lic. psychologist, PhD",[52],{"name":53,"class":54},"Region Stockholm","OTHER_GOV","100590766","metacognitive-therapy-vs-unified-protocol-for-patients-with-comorbid-anxiety-disorders-100590766",false,"NCT06971692","Metacognitive Therapy vs Unified Protocol for Patients With Comorbid Anxiety Disorders","Transdiagnostic Therapy With Metacognitive Therapy Versus Unified Protocol for Patients With Comorbid Anxiety Disorders: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 years or above\n* Ability to read and speak Swedish\n* A principal diagnosis of post-traumatic stress disorder, generalized anxiety disorder, social anxiety disorder, or panic disorder\n* At least one additional comorbid diagnosis (one of the above diagnoses, or obsessive-compulsive disorder, or major depressive disorder)\n* Patients on psychotropic medication must have been on a stable dose (excluding as-needed medication) for at least six weeks prior to treatment initiation\n\nExclusion Criteria:\n\n* Current diagnosis of psychosis, bipolar disorder or moderate to severe substance use disorder\n* Medium to high suicide risk\n* Psychiatric, somatic or social problems that require primary intervention other than the treatments offered in the study\n* Concurrent psychological treatment","ALL","18 Years",{"count":65,"type":66},114,"ESTIMATED","INTERVENTIONAL",[69],"NA","The primary goal of this randomized controlled trial is to compare the effectiveness of two transdiagnostic psychological treatments, Metacognitive Therapy (MCT) and the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), for patients with complex anxiety.",[72,73,74,75],"Posttraumatic Stress Disorder (PTSD)","Generalized Anxiety Disorder (GAD)","Social Anxiety Disorder (SAD)","Panic Disorder (With or Without Agoraphobia)","NOT_YET_RECRUITING","2025-05-06",{"date":79,"type":80},"2025-05-14","ACTUAL",{"date":82,"type":66},"2025-08",{"date":84,"type":66},"2028-12",{"name":5,"class":6},1]