[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100527290":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":10,"locations":23,"responsibleParty":47,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Guangzhou 8th People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pathogen metagenomic next-generation sequencing group",null,"This group uses metagenomic next-generation sequencing along with traditional pathogen detection techniques to test for infectious pathogens. The follow-up times are the 1st, 2nd, 3rd, and 4th weeks after being diagnosed with severe pneumonia or sepsis.",[13],"Diagnostic Test: Pathogen metagenomic next-generation sequencing",{"label":15,"type":10,"description":16,"interventionNames":10},"Conventional pathogen detection group","This group only used conventional pathogen detection methods for the identification of infectious pathogens. Follow-up was conducted at the 1st, 2nd, 3rd, and 4th weeks after the diagnosis of severe pneumonia or sepsis. The conventional means of pathogen detection include, but are not limited to, fungal serology tests, cryptococcal capsular antigen detection, CMV-DNA tests, sputum smear microscopy, gamma interferon release assays, Xpert MTB\u002FRIF, BLAF culture, blood and bone marrow cultures, radiological examinations, and histopathological examinations.",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"DIAGNOSTIC_TEST","Pathogen metagenomic next-generation sequencing","In diagnosing patients with AIDS combined with severe pneumonia and\u002For sepsis, use pathogen metagenomics technology to detect peripheral blood specimens",[9],[24],{"facility":25,"status":26,"city":27,"state":28,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Linghua Li","RECRUITING","Guangzhou","Guangdong","510060","China","CN",{"type":33,"coordinates":34},"Point",[35,36],113.25,23.11667,{"lat":36,"lon":35},[39,44],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"Linghua Li, PhD","CONTACT","+862083710825","llheliza@126.com",{"name":45,"role":41,"phone":42,"phoneExt":10,"email":46},"Yaozu He, MD","hyzdyl99@163.com",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Linghua LI","Chief physician","100527290","metagenomic-next-generation-sequencing-guides-anti-infection-strategies-100527290",false,"NCT06145841","Metagenomic Next-Generation Sequencing Guides Anti-Infection Strategies","Clinical Application of Metagenomic Next-Generation Sequencing-Guided Anti-Infection Strategies in AIDS Patients With Severe Pneumonia and\u002For Sepsis","Inclusion Criteria:\n\n1. Confirmed HIV infection;\n2. Progression to AIDS stage: CD4+ count \\\u003C200 cells\u002Ful and\u002For occurrence of AIDS opportunistic infections;\n3. Age between 18 and 65 years;\n4. Meeting the diagnosis of severe pneumonia or septic shock:\n\n   1. The criteria for severe pneumonia diagnosis refer to the 2021 ATS (American Thoracic Society) and IDSA (Infectious Diseases Society of America) guidelines for the treatment of community-acquired pneumonia;\n   2. The criteria for septic shock refer to the Chinese Society of Critical Care Medicine's \"Chinese Guidelines for the Emergency Treatment of Sepsis\u002FSeptic Shock (2018).\n\nExclusion Criteria:\n\n1. Coexisting central nervous system lesions, severe liver disease, or cirrhosis;\n2. Concurrent AIDS-related or unrelated tumors;\n3. Women who are pregnant or breastfeeding;\n4. Severe underlying diseases of the heart, lungs, liver, kidneys, etc.;\n5. Alcohol abuse or drug use;\n6. The researcher believes that the overall condition of the subject affects the evaluation and completion of the trial.","ALL","18 Years","65 Years",{"count":62,"type":63},400,"ESTIMATED","OBSERVATIONAL","This study aims to observe the effectiveness of clinical application in guiding anti-infection treatments in AIDS patients with severe pneumonia and\u002For sepsis using Metagenomic Next-Generation Sequencing-based technology in the real world",[67,68,69],"AIDS","Pneumonia","Sepsis, Neonatal",[67,71,72,73],"severe pneumonia","Sepsis","metagenomic next-generation sequencing","2023-11-17",{"date":76,"type":77},"2023-11-24","ACTUAL",{"date":79,"type":77},"2023-10-23",{"date":81,"type":63},"2027-10-23",{"name":5,"class":6},1]