[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599555":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":58,"collaborators":61,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Icahn School of Medicine at Mount Sinai","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"MSM - MUD (Current)",null,"Participants who are MSM and are currently using methamphetamine (MA abstinence: 2 weeks; range: 1-3 weeks).",[13],"Behavioral: Cognitive Reappraisal",{"label":15,"type":10,"description":16,"interventionNames":17},"MSM - MUD (Abstinent)","Participants who are MSM and are abstaining from using methamphetamine (MA abstinence: 3 months; range: 2-4 months).",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"non-MSM - MUD (Current)","Participants who are not MSM and are currently using methamphetamine (MA abstinence: 2 weeks; range: 1-3 weeks).",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"non-MSM - SUD (Abstinent)","Participants who are not MSM and are abstaining from using methamphetamine (MA abstinence: 3 months; range: 2-4 months).",[13],[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"BEHAVIORAL","Cognitive Reappraisal","an emotion-regulation strategy while being asked to complete cognitive tasks.",[15,9,19,23],[33],{"name":34,"affiliation":5,"role":35},"Muhammad A Parvaz, PhD","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Muhammad A Parvaz","CONTACT","212-241-3638","muhammad.parvaz@mssm.edu",[43],{"facility":5,"status":44,"city":45,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","New York","10029","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-74.00597,40.71427,{"lat":53,"lon":52},[56,57],{"name":34,"role":39,"phone":40,"phoneExt":10,"email":41},{"name":38,"role":35,"phone":10,"phoneExt":10,"email":10},{"type":35,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Muhammad Parvaz","Associate Professor",[62],{"name":63,"class":64},"National Institute on Drug Abuse (NIDA)","NIH","100599555","methamphetamine-cue-reactivity-100599555",false,"NCT07086014","Methamphetamine Cue-reactivity","Cue Reactivity Modulation in MSM With Methamphetamine Use Disorder","Inclusion Criteria:\n\n* Ability to understand and give informed consent\n* Identify as either MSM or non-MSM\n* Males; Age 18-60\n* DSM-5 Diagnosis of MUD (Methamphetamine Use Disorder)\n* Have appropriate abstinence duration \\[i.e., current Methamphetamine users (MA): 2 weeks (range: 1-3 weeks); MA-abstinent: 3 months (range: 2-4 months)\\]\n* Treatment-seeking MUD must be in a treatment facility for substance use disorder, with MA as the primary drug (at the first visit)\n* Treatment-seeking MUD must be abstinent from MA use for approximately 2 weeks (range: 1-3 weeks) at enrollment.\n\nExclusion Criteria:\n\n• Women","MALE","18 Years","60 Years",{"count":76,"type":77},88,"ESTIMATED","OBSERVATIONAL","In this observational cohort study, the researchers propose to first identify a psychophysiological marker of methamphetamine cue-reactivity and its incubation with abstinence from methamphetamine use (MUD) and examine group-differences between men who have sex with men (MSM) and non-MSM MUD.\n\nThe primary objective is to identify psychophysiological markers of methamphetamine (MA) cue-reactivity and its abstinence incubation. The secondary objective is to examine group-differences in methamphetamine use disorder (MUD) individuals between homosexual men (MSM) and heterosexual men (non-MSM). The primary endpoint is to assess incubation of cue-reactivity longitudinally with its reduction in cognitive reappraisal, and the secondary endpoint is to examine the impact of cognitive reappraisal on clinical outcomes of methamphetamine use disorder (MUD) in homosexual men (MSM).\n\n2-year long study. Screening and enrollment will be done at different locations of the Addiction Institute of Mount Sinai. The EEG session will be done at Icahn School of Medicine at Mount Sinai. Participation in the research study will be for a single EEG session.",[81],"Methamphetamine Use Disorder",[83,84,85,86,87,88],"methamphetamine","cue-reactivity","craving","EEG","incubation","cognitive reappraisal","2025-07-18",{"date":91,"type":92},"2025-07-25","ACTUAL",{"date":94,"type":92},"2024-08-19",{"date":96,"type":77},"2025-08-30",{"name":5,"class":6},1]