[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641094":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":40,"locations":46,"responsibleParty":62,"collaborators":30,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":94,"whyStopped":30,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Kufa University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Micro-Osteoperforation (MOP)","EXPERIMENTAL","Participants receive bilateral maxillary canine retraction using a standardized elastomeric power chain force of 150 g on 0.019×0.025-inch stainless steel archwires. Micro-osteoperforations are performed under local anesthesia using a PROPEL device (or equivalent). Six perforations of 3 mm depth are placed per canine (3 mesial, 3 distal) at baseline and repeated every 4 weeks until complete space closure.",[13],"Procedure: Micro-osteoperforation (MOP)",{"label":15,"type":10,"description":16,"interventionNames":17},"Photobiomodulation Therapy \u002F LLLT (976 nm)","Participants receive bilateral maxillary canine retraction using identical mechanics to the MOP group. A 976 nm diode laser (Woodpecker LX16 Plus or equivalent) is applied at 8 J\u002Fcm², 0.13 W, continuous-wave mode at 6 mucosal sites per canine (3 buccal, 3 palatal) on days 0, 3, 7, and 14, then every 2 weeks until complete space closure. No anesthesia is required.",[18],"Device: Photobiomodulation Therapy using 976 nm Diode Laser",{"label":20,"type":10,"description":21,"interventionNames":22},"Control (Conventional Orthodontic Retraction)","Participants receive standard bilateral maxillary canine retraction using a standardized elastomeric power chain force of 150 g on 0.019×0.025-inch stainless steel archwires. No adjunctive intervention is applied. This group serves as the comparator to quantify the absolute acceleration produced by MOP and LLLT.",[23],"Other: Conventional orthodontic canine retraction",[25,31,36],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Micro-osteoperforation (MOP)","Six micro-osteoperforations of 3 mm depth are created under local anesthesia (2% lidocaine with 1:100,000 epinephrine) using a PROPEL device or equivalent, with 3 perforations placed mesial and 3 distal to each maxillary canine on the buccal attached gingiva. The procedure is performed at baseline and repeated every 4 weeks until complete extraction space closure. All participants also receive standardized canine retraction using 150 g elastomeric power chain force on 0.019×0.025-inch stainless steel archwires",[9],null,{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":30},"DEVICE","Photobiomodulation Therapy using 976 nm Diode Laser","A 976 nm diode laser (Woodpecker LX16 Plus or equivalent) is applied in continuous-wave mode at a power of 0.13 W and energy density of 8 J\u002Fcm² per point. Irradiation is delivered at 6 mucosal sites per canine (3 buccal, 3 palatal) with the laser tip held perpendicular to the tissue surface at each point. Sessions are performed on days 0, 3, 7, and 14 after each activation, then every 2 weeks until complete extraction space closure. No anesthesia is required. All participants also receive standardized canine retraction using 150 g elastomeric power chain force on 0.019×0.025-inch stainless steel archwires",[15],{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":30},"Conventional orthodontic canine retraction","Standard bilateral maxillary canine retraction is performed using a standardized elastomeric power chain force of 150 g on 0.019×0.025-inch stainless steel archwires. Force is recalibrated at each monthly appointment. No adjunctive biological or physical intervention is applied. This arm serves as the active comparator to quantify the absolute acceleration produced by MOP and LLLT relative to conventional mechanics alone.",[20],[41],{"name":42,"role":43,"phone":44,"phoneExt":30,"email":45},"Almustafa wisam Ahumadi, master","CONTACT","009647821630001","almusafaw.alhumadi@uokufa.edu.iq",[47],{"facility":48,"status":30,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"University of Kufa College of Dentistry","Najaf","Kufa","54001","Iraq","IQ",{"type":55,"coordinates":56},"Point",[57,58],44.34625,32.02594,{"lat":58,"lon":57},[61],{"name":42,"role":43,"phone":44,"phoneExt":30,"email":45},{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Almustafa Alhumadi","lecturer","100641094","micro-osteoperforation-versus-photobiomodulation-therapy-for-accelerating-maxillary-canine-retraction-100641094",false,"NCT07658235","Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction","Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction: A Three-Arm Parallel Randomized Controlled Clinical Trial.","MOP-PBMT","Inclusion Criteria:\n\n* Age 18 to 40 years at the time of enrollment\n* Systemically healthy with no chronic medical conditions affecting bone metabolism or wound healing\n* Requiring bilateral maxillary first premolar extraction as part of a comprehensive fixed orthodontic treatment plan\n* Class I or mild Class II malocclusion requiring maximum anchorage canine retraction\n* Fully erupted maxillary permanent dentition with no missing teeth other than planned extraction teeth\n* Good oral hygiene (Plaque Index ≤ 1) and healthy periodontal status (probing depth ≤ 3 mm, no bleeding on probing)\n* No previous orthodontic treatment\n* Willing to attend all scheduled appointments and comply with study protocol\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Systemic diseases affecting bone metabolism including osteoporosis, osteopenia, diabetes mellitus, thyroid disorders, or autoimmune conditions\n* Current use of medications affecting bone remodeling including corticosteroids, bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), or vitamin D supplements\n* Current or recent smokers (within the past 6 months)\n* Pregnant or breastfeeding women\n* History of head and neck radiation therapy\n* Periodontal disease or active dental infection at the time of enrollment\n* Skeletal Class III malocclusion or severe Class II requiring surgical intervention\n* Previous orthodontic treatment or orthognathic surgery\n* Craniofacial syndromes or cleft lip and palate\n* Photosensitivity disorders or use of photosensitizing medications (relevant to LLLT group)\n* Coagulation disorders or anticoagulant therapy (relevant to MOP group)\n* Uncooperative patients or those unable to maintain adequate oral hygiene throughout treatment\n* Parafunctional habits such as severe bruxism or tongue thrusting'",true,"ALL","18 Years","40 Years",{"count":79,"type":80},75,"ESTIMATED","INTERVENTIONAL",[83],"NA","Orthodontic treatment often requires moving the upper canine teeth (the pointed teeth) into the spaces left after removing premolar teeth. This process is usually slow and can take many months, making the total treatment time longer.This study will compare two techniques that may speed up this tooth movement:\n\nMicro-osteoperforation (MOP): A minimally invasive procedure in which a small device is used to create tiny holes in the jawbone near the canine tooth under local anesthesia. These micro-perforations stimulate the bone to remodel faster, which allows the tooth to move more quickly.\n\nPhotobiomodulation therapy (PBMT) \u002F Low-Level Laser Therapy (LLLT): A painless, non-invasive technique that uses a low-power laser light applied to the gum tissue near the canine tooth. The laser energy stimulates cells in the bone and supporting tissues to accelerate tooth movement without any cutting or drilling.\n\nThis trial will randomly assign eligible patients into one of three groups: MOP, LLLT, or a control group receiving standard orthodontic treatment only. Each group will contain 25 participants (75 total). The main goal is to measure and compare how fast the upper canine tooth moves in each group over the first month and until the space is fully closed. The study will also measure the effect of age and sex on the results. The findings will help orthodontists choose the best, fastest, and most comfortable method for each patient to shorten overall treatment time",[86,87,88],"Malocclusion","Orthodontic Tooth Movement","Maxillary Canine Retraction",[90,91,92,93],"Micro-osteoperforation","Photobiomodulation therapy","low-level laser therapy","acceleration of tooth movement","NOT_YET_RECRUITING","2026-06-16",{"date":97,"type":98},"2026-06-18","ACTUAL",{"date":100,"type":80},"2026-07-01",{"date":102,"type":80},"2027-05-28",{"name":5,"class":6},1]