[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624812":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":42,"locations":52,"responsibleParty":73,"collaborators":75,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":81,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":29,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":55,"whyStopped":29,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"University Hospital Muenster","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Resective Periodontal Surgery","EXPERIMENTAL","Participants in this arm undergo subgingival microbiome sampling in the context of resective periodontal surgery. Microbiome samples are collected at standardized time points (preoperative baseline, intraoperative sampling, and postoperative follow-ups). Samples are analyzed using next-generation sequencing (NGS), including 16S rRNA profiling, and Structure-Microbial Diversity Index (SMDI) evaluation. The goal is to characterize microbial shifts associated with resective periodontal therapy.",[13],"Procedure: Resective Periodontal Surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"Regenerative Periodontal Surgery","Participants undergoing regenerative periodontal therapy are enrolled for longitudinal subgingival microbiome analysis. Microbiome samples are obtained at predefined time points (baseline, intraoperative, postoperative). Sequencing is performed using next-generation sequencing (NGS) and 16S rRNA analysis, with SMDI calculations to assess microbial diversity changes associated with regenerative procedures.",[18],"Procedure: Regenerative Periodontal Surgery",{"label":20,"type":10,"description":21,"interventionNames":22},"Peri-Implantitis Surgery","Participants in this arm receive systematic peri-implant microbiome profiling before, during, and after peri-implantitis surgery. Sampling includes submucosal\u002Fperi-implant biofilm collection at standardized visits. Analyses include next-generation sequencing (NGS), 16S rRNA sequencing, and SMDI-based microbial diversity assessment to evaluate microbial changes associated with peri-implantitis therapy.",[23],"Procedure: Surgical Peri-implantitis Therapy",[25,30,33],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","Apically repositioned full-thickness mucoperiosteal flap with resective surgical treatment of periodontal defects. Includes removal of inflamed tissue and recontouring of osseous structures according to clinical indication. Microbiome samples are taken pre-, intra- and postoperatively.",[9],null,{"type":26,"name":15,"description":31,"armGroupLabels":32,"otherNames":29},"Regenerative periodontal therapy including the use of autogenous bone, membranes, and\u002For bone substitute materials for periodontal regeneration.",[15],{"type":26,"name":34,"description":35,"armGroupLabels":36,"otherNames":29},"Surgical Peri-implantitis Therapy","Surgical intervention for peri-implantitis including surgical access flap, defect debridement, implant surface decontamination, and resective or regenerative procedures as clinically indicated.",[20],[38],{"name":39,"affiliation":40,"role":41},"Benjamin Ehmke, Univ. Prof. Dr. med. dent.","Clinic for Periodontology and Conservative Dentistry, University of Münster","PRINCIPAL_INVESTIGATOR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":29,"email":47},"Benjamin Ehmke, Univ. -Prof. Dr. med. dent.","CONTACT","+4902518347059","ehmke@uni-muenster.de",{"name":49,"role":45,"phone":50,"phoneExt":29,"email":51},"Daniel Hagenfeld, PD Dr. med. dent.","+492518345092","Daniel.hagenfeld@ukmuenster.de",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"University Hospital Münster","RECRUITING","Münster","North Rhine-Westphalia","48149","Germany","DE",{"type":62,"coordinates":63},"Point",[64,65],7.62571,51.96236,{"lat":65,"lon":64},[68,70],{"name":69,"role":45,"phone":46,"phoneExt":29,"email":47},"Benjamin Ehmke, Univ.-Prof. Dr. med. dent.",{"name":71,"role":45,"phone":50,"phoneExt":29,"email":72},"Maher Heno","Maher.heno@ukmuenster.de",{"type":74,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR",[76],{"name":77,"class":78},"dfg","UNKNOWN","100624812","micro-surg-subgingival-microbiome-in-peri-implantitis-regenerative-and-resective-periodontal-surgery-100624812",false,"NCT07414498","MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal Surgery","MICRO-SURG: Investigation of Subgingival Microbiome Changes Following Surgical Peri-Implantitis Therapy, Regenerative Periodontal Surgery, and Resective Periodontal Surgery Using Next-Generation Sequencing","MICROSURG","Inclusion Criteria:\n\n* Age 18 years or older\n* Confirmed diagnosis of Peri-implantitis (for the peri-implantitis surgery arm), or Stage III\u002FIV periodontitis (for the periodontal surgery arms)\n* Indication for surgical therapy corresponding to the assigned study arm\n* Ability to understand the study procedures and provide written informed consent\n* Adequate oral hygiene (API\u002FSBI according to the clinician's judgment)\n* Willingness and ability to attend all follow-up visits\n* Willingness to provide salivary and subgingival plaque samples for microbiome analyses (NGS, SMDI)\n\nExclusion Criteria:\n\n* Systemic conditions contraindicating oral surgical procedures\n* Severe systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders)\n* Use of systemic antibiotics within the previous 3 months\n* Active COVID-19 infection at the time of surgery\n* Pregnancy or breastfeeding\n* Drug or alcohol abuse\n* Smoking more than 10 cigarettes per day\n* Known allergies to materials used in the assigned intervention (e.g., local anesthetics, sutures, membranes, bone grafting materials)\n* Participation in another clinical study within the previous 30 days\n* Acute oral infections that contraindicate participation\n* Inability or unwillingness to comply with all follow-up appointments Lack of capacity to provide informed consent","ALL","18 Years","80 Years",{"count":91,"type":92},84,"ESTIMATED","INTERVENTIONAL",[95],"NA","This clinical study investigates how the subgingival microbiome changes after three different periodontal and peri-implant surgical procedures: (1) resective periodontal surgery, (2) regenerative periodontal surgery, and (3) peri-implantitis surgery. The aim is to characterize microbial shifts associated with these commonly used surgical treatments and to determine whether the type of surgery influences the recovery or disruption of the subgingival ecosystem. Adult patients with periodontitis or peri-implantitis will receive the procedure indicated for their condition. Subgingival plaque samples will be collected at baseline and at defined postoperative follow-up intervals. Microbiome analysis will be performed using next-generation sequencing (NGS), and microbial changes will be evaluated with the Subgingival Microbial Dysbiosis Index (SMDI). Insights from this study may help improve prevention, diagnostics, and treatment strategies for periodontal and peri-implant diseases.",[98,99],"Periodontitis","Periimplantitis",[101,102,103,104,20,105,106,107,108],"Subgingival Microbiome","Periodontal Surgery","Regenerative Surgery","Resective Surgery","Next-Generation Sequencing","16S rRNA Sequencing","Microbiome Analysis","SMDI","2026-04-28",{"date":111,"type":112},"2026-05-05","ACTUAL",{"date":114,"type":112},"2026-02-23",{"date":116,"type":92},"2026-06-01",{"name":5,"class":6},1]