[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100532002":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":55,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":24,"overallStatus":38,"whyStopped":24,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention healthy diet","EXPERIMENTAL","Participants in the active intervention group will have specific diet advice delivered with motivational and behaviour-change techniques and will learn relevant cooking skills in remotely-delivered group cooking classes (via Zoom).",[13],"Other: Mediterranean-style diet",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard diet","ACTIVE_COMPARATOR","The active control group will focus on an energy-adequate diet considered standard-of-care but similar to the participant's baseline diet. The control dietary intervention group will receive general diet advice and standard care and will receive instruction in cooking skills delivered in remote group cooking classes (via Zoom).",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Mediterranean-style diet","Coaching in the intervention diet group will promote higher consumption of healthier foods and cooking oils, while discouraging processed foods.",[9,15],null,[26],{"name":27,"affiliation":5,"role":28},"Silke Appel-Cresswell, MD, FRCPC","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Annie Kuan","CONTACT","604-827-0576","annie.kuan@ubc.ca",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"UBC Pacific Parkinson's Research Centre","RECRUITING","Vancouver","British Columbia","V6T 2B5","Canada","CA",{"type":45,"coordinates":46},"Point",[47,48],-123.11934,49.24966,{"lat":48,"lon":47},[51],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},{"type":28,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Silke Cresswell","Principal Investigator, Associate Professor Medicine, MD, FRCPC",[56],{"name":57,"class":6},"Weston Family Foundation","100532002","microbiome-and-diet-in-parkinsons-disease-100532002",false,"NCT06207136","Microbiome and Diet in Parkinson's Disease","Canadian Parkinson's Microbiome Initiative: A Pilot Phase 2 Feasibility Randomized Controlled Trial of the MIND Diet in Parkinson's Disease","PD-Diet","Inclusion Criteria:\n\nEligible if the person living with Parkinson's has\u002Fis:\n\n1. a clinical diagnosis of PD,\n2. cognitively stable (no clinical dementia),\n3. between 40-80 years old,\n4. able to travel to UBC for 6 onsite visits over 18 months,\n5. sufficient English proficiency (coaching and cooking classes are in English only),\n6. on a stable dopaminergic medication for at least one month before baseline,\n7. computer and internet access at home, and can be available via video link for at least 80% of the study sessions.\n\nExclusion Criteria:\n\nNot eligible, if person has\u002Fis:\n\n1. a diagnosis of atypical parkinsonism,\n2. medical or psychiatric conditions that would prevent full participation in the nutrition intervention (such as food allergies), significant dysphagia, diabetes on insulin, anti-coagulation on warfarin, and inflammatory bowel disease,\n3. clinical dementia,\n4. unable to complete questionnaires or understand study instructions,\n5. using of immunomodulatory agents,\n6. used Probiotics in the last 4 weeks prior to study start,\n7. used Antibiotics in the last 3 months prior to study start,\n8. contraindications for MRI.","ALL","40 Years","80 Years",{"count":70,"type":71},40,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this pilot study is to examine the feasibility and effects of an 18-month intervention diet compared to an active control diet (standard diet) in those living with Parkinson's Disease (PD), without dementia.\n\nResearch has shown that eating components of Mediterranean diets are associated with a 30% lower risk to develop PD and a 40% lower mortality rate in those living with PD. Diet may influence the gut and microbiomes, thus may affect PD risk and progression.\n\nThis study will examine how easy it will be to adhere to a certain type of diet for 18 months and what changes may occur in the gut microbiome and in PD symptoms on a specific diet during that time.\n\nThe study will involve in-person study visits at UBC as well as online diet coaching sessions and online group cooking classes over Zoom.\n\nThis is a randomized study, meaning that participants will be assigned by chance to either the Mediterranean-style diet group or the standard diet group for the duration of the 18 months.\n\nThis pilot study will also examine recruitment rates and retention, in order to prepare for a larger future study.",[77,78,79,80],"Parkinson Disease","Diet, Healthy","Gut Microbiome","Gastrointestinal Microbiome","2026-03-19",{"date":83,"type":84},"2026-03-23","ACTUAL",{"date":86,"type":84},"2024-12-03",{"date":88,"type":71},"2027-12-31",{"name":5,"class":6},1]