[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633895":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":20,"locations":29,"responsibleParty":78,"collaborators":10,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":10,"studyType":96,"phases":10,"briefSummary":97,"conditions":98,"keywords":105,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Couples Undergoing IVF Treatment",null,"Prospective cohort of couples undergoing in vitro fertilization (IVF) treatment at participating in a multicenter fertility clinics in Sweden. Biological samples are collected from both partners for microbiome and metabolome profiling, and participants are followed longitudinally for reproductive and obstetric outcomes through linkage with national health registers.",[13,17],{"name":14,"affiliation":15,"role":16},"Kenny A. Rodriguez-Wallberg, MD., PhD","Oncology-pathology, Karolinska Institutet","PRINCIPAL_INVESTIGATOR",{"name":18,"affiliation":5,"role":19},"Hana Shabana, MD, PhD candidate","STUDY_DIRECTOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Ola Larsson, PhD","CONTACT","+46 8 524 80000","ola.larsson@ki.se",{"name":27,"role":23,"phone":10,"phoneExt":10,"email":28},"Hanna Nilsson, PhD","hanna.nilsson@ki.se",[30,47,65],{"facility":31,"status":32,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Reproduktionsmottagning Malmö, Skånes universitetssjukhus","RECRUITING","Malmö","Sweden","SE",{"type":37,"coordinates":38},"Point",[39,40],13.00073,55.60587,{"lat":40,"lon":39},[43,46],{"name":44,"role":23,"phone":10,"phoneExt":10,"email":45},"Margareta Kitlinski, MD, PhD","margareta.kitlinski@skane.se",{"name":44,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":48,"status":32,"city":49,"state":10,"zip":50,"country":34,"countryCode":35,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Karolinska Universitetssjukhuset","Stockholm","146 32",{"type":37,"coordinates":52},[53,54],18.06871,59.32938,{"lat":54,"lon":53},[57,61,63],{"name":58,"role":23,"phone":59,"phoneExt":10,"email":60},"Hana Shabana, MD","+46721775326","hana.shabana@ki.se",{"name":62,"role":23,"phone":59,"phoneExt":10,"email":60},"Kenny A Rodriguez-Wallberg, MD, PhD",{"name":64,"role":16,"phone":10,"phoneExt":10,"email":10},"Hana Shabana, MD., PhD candidate",{"facility":66,"status":32,"city":67,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Reproduktionscenter, Akademiska sjukuhset","Uppsala",{"type":37,"coordinates":69},[70,71],17.63889,59.85882,{"lat":71,"lon":70},[74,77],{"name":75,"role":23,"phone":10,"phoneExt":10,"email":76},"Farnaz Bazargani, MD","farnaz.bazargani@akademiska.se",{"name":75,"role":16,"phone":10,"phoneExt":10,"email":10},{"type":16,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Kenny Rodriguez-Wallberg","MD., Professor","100633895","microbiome-and-metabolome-profiles-in-couples-undergoing-ivf-and-reproductive-outcomes-100633895",false,"NCT07532629","Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes","Microbiome and Metabolome Profiles in Couples Undergoing IVF and Their Association With Reproductive Outcomes in a Prospective Longitudinal Cohort Study","Mi IVF","Inclusion Criteria:\n\n* Women aged 18 to 40 years at enrolment.\n* Men aged between 18 to 56 years at enrolment.\n* Couples planning to undergo IVF treatment at a participating centre.\n* Sufficient understanding of spoken and written Swedish or English to provide informed consent and complete the web-based questionnaire.\n\nExclusion Criteria:\n\n* Pregnancy at the time of enrolment (confirmed or suspected).\n* Recent systemic antibiotic use within the past 4 weeks\n* Active vaginal or genital tract infection at the time of sampling",true,"ALL","18 Years","40 Years",{"count":94,"type":95},1000,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization. Biological samples will be collected from both female and male partners, including semen, vaginal, and blood samples, to characterize microbial composition and metabolic profiles. The study aims to examine how these biological profiles are associated with reproductive outcomes such as fertilization, pregnancy, miscarriage, and live birth. Participants will be followed longitudinally, and reproductive and obstetric outcomes will be obtained through linkage with national health registers.",[99,100,101,102,103,104],"Infertility","Assisted Reproductive Technology","Pregnancy Complications","Pregnancy Loss, Early","Metabolome","Microbiome",[106,104,103,107,108],"IVF","Male fertility","Pregnancy outcome","2026-04-13",{"date":111,"type":112},"2026-04-16","ACTUAL",{"date":114,"type":112},"2022-06-10",{"date":116,"type":95},"2029-03-01",{"name":5,"class":6},3]