[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100484292":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":52,"centralContacts":57,"locations":67,"responsibleParty":92,"collaborators":95,"id":101,"slug":102,"hasResults":103,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":103,"sex":109,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":62,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":62,"overallStatus":121,"whyStopped":62,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},{"fullName":5,"class":6},"Institut de Recherche en Sciences de la Sante, Burkina Faso","OTHER_GOV",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Microbiome-directed food (MDF) - MAM","EXPERIMENTAL","Each (MAM) child will receive a daily ration of MDF corresponding to his weight, for maximum 12 weeks",[13],"Dietary Supplement: Microbiome-directed food - MAM",{"label":15,"type":16,"description":11,"interventionNames":17},"Ready-to-use supplementary food (RUSF)","ACTIVE_COMPARATOR",[18],"Dietary Supplement: Ready-to-use supplementary food (RUSF)",{"label":20,"type":10,"description":21,"interventionNames":22},"Microbiome-directed food (MDF) - SAM","Each (SAM) child will receive a daily ration of MDF corresponding to his weight, for maximum 12 weeks of supplementation.",[23],"Dietary Supplement: Microbiome-directed food (MDF) - SAM",{"label":25,"type":16,"description":26,"interventionNames":27},"Ready-to-use therapeutic food (RUTF)","Each (SAM) child will receive a daily ration of RUTF corresponding to his weight, for maximum 12 weeks of supplementation",[28],"Dietary Supplement: Ready-to-use therapeutic food (RUTF)",[30,37,42,47],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DIETARY_SUPPLEMENT","Microbiome-directed food - MAM","Each MAM child will be supplemented with MDF for a maximum of 12 weeks. He will be followed subsequently up to 24 weeks.",[9],[36],"MDF - MAM",{"type":31,"name":15,"description":38,"armGroupLabels":39,"otherNames":40},"Each MAM child will be supplemented with RUSF for a maximum of 12 weeks. He will be followed subsequently up to 24 weeks.",[15],[41],"RUSF",{"type":31,"name":20,"description":43,"armGroupLabels":44,"otherNames":45},"Each SAM child will be supplemented with MDF for a maximum of 12 weeks. He will be followed subsequently up to 24 weeks.",[20],[46],"MDF - SAM",{"type":31,"name":25,"description":48,"armGroupLabels":49,"otherNames":50},"Each SAM child will be supplemented with RUTF for a maximum of 12 weeks. He will be followed subsequently up to 24 weeks.",[25],[51],"RUTF",[53],{"name":54,"affiliation":55,"role":56},"Seni KOUANDA, MD., PhD","Institut de Recherche en Sciences de la Santé, Burkina-Faso","PRINCIPAL_INVESTIGATOR",[58,64],{"name":59,"role":60,"phone":61,"phoneExt":62,"email":63},"Hermann Biènou LANOU, MD., PhD.","CONTACT","+226 66557580",null,"hlanou@yahoo.ca",{"name":54,"role":60,"phone":65,"phoneExt":62,"email":66},"+226 70261462","senikouanda@gmail.com",[68],{"facility":69,"status":62,"city":70,"state":71,"zip":62,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"LANOU Hermann Bienou","Ouagadougou","Kadiogo","Burkina Faso","BF",{"type":75,"coordinates":76},"Point",[77,78],-1.53388,12.36566,{"lat":78,"lon":77},[81,83,85,88,90],{"name":82,"role":60,"phone":61,"phoneExt":62,"email":63},"Hermann Biènou LANOU, MD., PhD",{"name":84,"role":60,"phone":65,"phoneExt":62,"email":66},"Seni KOUANDA, MD.,PhD",{"name":86,"role":87,"phone":62,"phoneExt":62,"email":62},"Hermann LANOU, PhD.","SUB_INVESTIGATOR",{"name":89,"role":87,"phone":62,"phoneExt":62,"email":62},"Jérôme SOME, PhD",{"name":91,"role":56,"phone":62,"phoneExt":62,"email":62},"Seni KOUANDA, PhD",{"type":56,"investigatorFullName":93,"investigatorTitle":94,"investigatorAffiliation":5,"oldNameTitle":62,"oldOrganization":62},"Hermann Lanou","Principal Investigator",[96,98],{"name":97,"class":6},"Ministry of Health, Burkina Faso",{"name":99,"class":100},"Bill and Melinda Gates Foundation","OTHER","100484292","microbiome-directed-food-for-sustained-recovery-from-acute-malnutrition-100484292",false,"NCT05586139","Microbiome-Directed Food for Sustained Recovery From Acute Malnutrition","Efficacy of a Food Targeting the Microbiota for a Sustained Recovery of Children With Uncomplicated Acute Malnutrition","MDF","Inclusion Criteria:\n\n* Age between 6 and 23 months\n* Moderate wasting: WHZ \\\u003C -2 and ≥ -3 or MUAC \\\u003C 125 mm and ≥ 115mm or - Severe wasting: WHZ \\\u003C -3 or MUAC \\\u003C 115 mm\n\nExclusion Criteria:\n\n* Bilateral pitting edema\n* Not eating\u002Flack of appetite\n* Current illness medical complications requiring inpatient treatment\n* Presence of any congenital abnormality or underlying chronic disease that may affect growth or risk of infection\n* Known contraindication\u002Fhypersensitivity\u002Fallergy to MDCF of RUSF ingredients (chickpea flour, soy flour, banana, peanut)\n* Relapse from MAM treatment or transfer from SAM treatment\n* Children recently (\\\u003C2 months) or enrolled in a nutrition program\n* Residence outside the study area","ALL","6 Months","23 Months",{"count":113,"type":114},6200,"ESTIMATED","INTERVENTIONAL",[117],"NA","The goal of this experimental study is to test the efficacy of a new formulation - The microbiome-directed food (MDF) to treat acute malnutrition among children aged 6 to 23 months. The main questions are:\n\n* Does treating children with moderate or severe uncomplicated malnutrition using MDF leads to higher programmatic recovery rate compared to standard of care ?\n* Does treating children with moderate or severe uncomplicated malnutrition using MDF leads to higher sustained recovery rate compared to standard of care ? The MDF will be compared to Ready-to-use supplementary food (RUSF) for moderately malnourished children, and to Ready-to-use therapeutic food (RUTF) for severely malnourished children to see the effects on recovery and sustained recovery rate.",[120],"Acute Malnutrition With no Complications","NOT_YET_RECRUITING","2024-03-12",{"date":124,"type":125},"2024-03-13","ACTUAL",{"date":127,"type":114},"2024-10",{"date":129,"type":114},"2026-12",{"name":5,"class":6},1]